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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#111

Post by kdmccormick »

awelkie wrote: post #109
ejolto wrote: post #96

Earlier quoted context omitted.

Dude. CBD is antipsychotic[1] and thus might help people with schizophrenia. THC is psychoactive [2] and should probably be avoided by people with schizophrenia. [1] https://www.ncbi.nlm.nih.gov/pubmed/22716160 [2] https://www.ncbi.nlm.nih.gov/pubmed/28492950

I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.

Yes, but the replier is saying that THC, the primary active compound in Cannabis, can in fact worsen some of the symptoms of schizophrenia. As someone with Type I Bipolar, which has many similarities to schizophrenia, I agree that this is often the case.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#112

Post by slfnflctd »

pryce wrote: post #33
jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

No control group, no placebo, not blinded, not double-blinded, small sample size. The only possible real takeaway from a study like this is that it appears to support undertaking a larger, more expensive & more robust study on in determining whether CBD may have benefits in treating anxiety and insomnia. Seeing a candidate treatment at such an incredibly embryonic stage being voted to the top spot of hacker news, to…

> a candidate treatment at such an incredibly embryonic stage being voted to the top spot of hacker news, to me, suggests our HN audience has significant room for improvement

It's a super hot topic right now because these shops have suddenly popped up all over the country - including in cannabis prohibition states - and some of them must be making a good amount of money for there to be so many. Business minded people are acutely interested in where this thing is going long term, so any data at all is seized upon, no matter how dubious.

This, of course, makes comments like yours even more important and appreciated.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#113

Post by phito »

inciampati wrote: post #53
gnulinux wrote: post #50

Earlier quoted context omitted.

Just a data point. I dealt with anxiety my entire life, and too much weed absolutely destroys me but small amount of weed definitely calms me down. When I smoke too much weed, it really doesn't feel like my anxieties deep down are surfaces. It feels like my brain is making up new stupid things. To me, weed is a very strong sensory experience. When I'm too high it almost feels I'm hearing too much, feeling too much, s…

What kind of made up anxiety have you encountered? I ask just to understand. I've never run into an anxiety after smoking weed that wasn't rooted in reality. I find it helpful for the same reasons the previous poster stated.

For me it's just the feeling of anxiety, no specific anxiety inducing subject is running through my head and no paranoia. When I eat edibles (which I do rarely and almost always regret it) the anxiety is worse, I get really cold and my whole body shakes.

I stick to small amounts of vaped weed and I can enjoy it

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#114

Post by ejolto »

kdmccormick wrote: post #111
awelkie wrote: post #109

Earlier quoted context omitted.

I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.

Yes, but the replier is saying that THC, the primary active compound in Cannabis, can in fact worsen some of the symptoms of schizophrenia. As someone with Type I Bipolar, which has many similarities to schizophrenia, I agree that this is often the case.

This is exactly what I meant. Thanks for sharing your experience.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#115

Post by mettamage »

ryanlol wrote: post #90
mettamage wrote: post #19

Earlier quoted context omitted.

To summarize a bit unnuanced: THC induces paranoia CBD reduces it The ratio is an important one between them as it alters the experience a lot. Weed is a bit like love, the term is convoluted and overloaded. E.g. Dutch weed: HIGH in THC! Normal in CBD. Oh dear, the Dutchies... Sigh Swiss weed: high in CBD, extremely low in THC The experience? Completely different. Sources (cannot Google search atm, am on mobile): - I…

I smoke THC distillate with essentially no CBD, I find it to be calming and not to induce anxiety or paranoia.

That's possible, for some it does nothing, for others it can be the path to non-recoverable schizophrenia. My advice to people who smoke high THC is: if you have had weed-induced psychosis then you might be able to develop schizophrenia with prolonged use of high THC weed. In other words: smoke seldomly.

However, it might also be possible that one simply doesn't notice their cognitive decline. To check on this, people would need to listen carefully to their environment. If they say something is wrong with you, then something is probably not right indeed.

The reason for this is: schizophrenia and psychosis related phenomenon take away the ability to self-reflect.

Unfortunately, I don't have sources for this, other than that I read up on it. But for now, it simply is just one opinion on the internet. Search engines are your friend here, especially academic search engines. And I have friends who are psychiatrists, so those conversations help.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#116

Post by chisleu »

Small study with mostly small doses and better than expected outcomes IMHO.

I have several friends using CBD for anxiety and depression (in addition to normal meds.)

IMHO, it has profound potential medically. Anecdotal evidence is unreliable, but one close friend of mine started taking doses at my insistence while going through cocaine and heroine withdrawal. It make a profoundly noticeable change in her attitude.

I hope that more clinical studies are funded regarding it's use for those matters because a cheap and readily available medicine to help with these symptoms is severely needed to help those seeking to end their addictions would be greatly beneficial to society at large.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#117

Post by amelius »

JamesBarney wrote: post #92
oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

Just a heads up. The glycine(of the glycinate) might be helping just as much as the magnesium. Glycine is relaxing and theorized to help with schizophrenia. (through nmda signalling) If you're interest in other supplements that have preliminary evidence for helping with schizophrenia are bacopa and sodium benzoate are maybe worth a try. [0][1] - Obviously talk to your doctor about it. https://www.ncbi.nlm.nih.gov/pub…

> sodium benzoate

Note that in combination with vitamin C, sodium benzoate may form benzene, which is toxic. But perhaps this is only relevant if you store them together, and at higher temperatures (?)

https://en.wikipedia.org/wiki/Sodium_benzoate#Association_wi...

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#118

Post by scott_s »

jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

Not only that, the CBD was given in addition to normal treatment: "A large retrospective case series at a psychiatric clinic involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment."

This study design prevents us from making any strong conclusions on CBD. Was it the normal treatment that helped, or the CBD? With no controls, and no separation of standard treatment and the new intervention, we can't conclude anything. In defense of the study authors, they don't make a strong conclusion, and call for controlled clinical trials. But I doubt people talking about the study will be that restrained.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#119

Post by JibJabDab »

jaequery wrote: post #41
mettamage wrote: post #3

Why I post this: I am trying to sleep but can’t (on my phone to not wake anyone). I was wondering whether CBD might help. The study is simply a discussion prompt. My query also found [1]. I wonder who else has some insight into CBD. Edit: since this comment is quite down the discussion thread I would like to promote another topic [2]. It is about creating wearables that are able to measure stress. Measuring stress [2…

I’ve had chronic insomnia for over 3 years. The day I started CBD, was about 4 months ago. Right before that, my option was to try Ambien that I had to pry off from the doctors hands. I’ve not had the guts to try it after hearing it messes with your brain and causes you to have suicidal thoughts. So I tried CBD after a quick research. First night, I didn’t feel a difference. I did feel a bit sleepier but I thought th…

What method did you take cbd (pill, etc..)?

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#120

Post by mettamage »

chisleu wrote: post #116

Small study with mostly small doses and better than expected outcomes IMHO. I have several friends using CBD for anxiety and depression (in addition to normal meds.) IMHO, it has profound potential medically. Anecdotal evidence is unreliable, but one close friend of mine started taking doses at my insistence while going through cocaine and heroine withdrawal. It make a profoundly noticeable change in her attitude. I…

I have the same hope, which is why I posted this. Moreover, I emailed the first author so they would be aware of the discussion here.
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