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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#31

Post by ZeroFries »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

One more factor, besides the ones other posters have pointed out, is tolerance. I find my tolerance to the anxiety provoking effects increases faster than my tolerance to the anxiolytic effects. If I haven't consumed any in a while, I find I can get that initial panic. Ride it out though and the more relaxing effects take over.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#32

Post by Chazprime »

throwaway8879 wrote: post #18
Chazprime wrote: post #12

Interesting to see an actual study, even if it’s a small test group. I’m usually getting maybe 4-5 hours of sleep a night, so about 6 months ago I started taking CBD oil at night (500mg and then 1500mg hemplucid). My experiences are pretty consistent with the study results here - I’d get about 1-1.5 hours more a night for the first month, but by month two I was already graduating to the 1500mg strength because my bod…

I had the same 4-5 hours sleep issue until I started to exercise/run regularly. Being a recovering addict/alcoholic, I usually avoid any dependencies, which is why I can't start taking a substance, even if it helps with sleep. In any case, are you getting regular exercise?

Exercise was the answer for me as well.

I usually run in the morning, but switching to evenings proved more effective for sleeping longer.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#33

Post by pryce »

jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

No control group, no placebo, not blinded, not double-blinded, small sample size.

The only possible real takeaway from a study like this is that it appears to support undertaking a larger, more expensive & more robust study on in determining whether CBD may have benefits in treating anxiety and insomnia.

Seeing a candidate treatment at such an incredibly embryonic stage being voted to the top spot of hacker news, to me, suggests our HN audience has significant room for improvement in ascertaining the quality or implications of published scientific studies.

EDIT: In particular, a risk here is that readers here might feel encouraged to try smoking cannabis for self-treatment of anxiety or insomnia, which is quite a different thing than taking CBD itself. Specifically, recreational cannabis is intentionally grown to have a high THC content, and THC can and does have negative consequences for those people suffering from anxiety.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#34

Post by nutjob2 »

Chazprime wrote: post #12

Interesting to see an actual study, even if it’s a small test group. I’m usually getting maybe 4-5 hours of sleep a night, so about 6 months ago I started taking CBD oil at night (500mg and then 1500mg hemplucid). My experiences are pretty consistent with the study results here - I’d get about 1-1.5 hours more a night for the first month, but by month two I was already graduating to the 1500mg strength because my bod…

I think you may have actually been medicating for the CBD side effect. I found when I started taking CBD that it helped a lot with anxiety but made me a little drowsy and helped my sleep somewhat. Over the next week or two the drowsiness mostly went away and my sleep was back to normal but it still helped with anxiety.

Unless your poor sleep is driven by anxiety, CBD is probably not the best choice. Some strain of Indica pot is probably what you are looking for.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#35

Post by Chazprime »

pifuoweiuf983 wrote: post #21
Chazprime wrote: post #12

Interesting to see an actual study, even if it’s a small test group. I’m usually getting maybe 4-5 hours of sleep a night, so about 6 months ago I started taking CBD oil at night (500mg and then 1500mg hemplucid). My experiences are pretty consistent with the study results here - I’d get about 1-1.5 hours more a night for the first month, but by month two I was already graduating to the 1500mg strength because my bod…

jesus that's pricey. Was gonna say, why not just take a puff of the joint at the end of the day?

It can sometimes be tough being married and starting a habit like that when your spouse doesn’t partake often.

Yes, smoking is more effective than CBD, but exercise won out eventually.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#36

Post by whalesalad »

hn_throwaway_99 wrote: post #23
spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

In my experience, if I smoke a very small amount of weed (like literally one hit) it can relax me and make me less anxious. It slows things down, and can just generally numb some of my underlying anxieties. However, it doesn't take much for me to cross that threshold where it can make me extremely paranoid. Usually this is what I call the "will I be stuck this way forever" threshold, where I get stoned to the point w…

The less you use, the more your body will become sensitive to the smaller amounts of it. Meaning, if you dose correctly, you can actually use less to achieve more.

So yep, dosage is extremely critical with THC.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#37

Post by whalesalad »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

Not a stupid question. Stigma around the plant has created this vacuum of pop-culture knowledge on this sort of thing.

Over a hundred different cannabinoids have been identified. CBD is a cannabinoid, and so is THC. THC is what makes you high. CBD does not.

You really need to get high with a scientist who has a ton of experience with weed. Then you can actually try different things, knowing what you are ingesting and using different methods, too (like vaporizing oil vs. smoking a flower)

Check this out to learn more about all the different cannabinoid's that we know about: https://en.wikipedia.org/wiki/Cannabinoid

Final thing to add would be to take a look at this picture: https://blogodiversity.files.wordpress.com/2012/09/dogs_of_t... and then think about all of your various experiences with dogs throughout your life. Dogs are all dogs, but they are TOTALLY different across breeds and even within breeds. The same applies to Marijuana... you will enjoy or dislike the characteristics of certain strains the same way you might like or dislike a dog or cat.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#38

Post by minikites »

mettamage wrote: post #5
jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

I was kind of surprised to read that CBD wasn’t studied that much in the firzt place.

That's what happens when a drug is Schedule I without medical or scientific basis (it was merely racism).

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#39

Post by duncan-donuts »

hrangozz wrote: post #28
spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

It wasn't until things were legalized that I had the option to try a 1:1 strain (equal ratio of CBD to THC) and I've found that to be a much better balance for me. The psychoactive aspects are still there, but less intense, more relaxing and without negative feelings. Kind of like sipping beer vs shooting tequila.

This is the most exciting thing about legalization to me. If I could go buy high cbd strains with a manageable level of thc I’d be first in line. I don’t want to get super high on thc. I just want all of the other effects.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#40

Post by rectang »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

Here's one possible vector... Intoxicants in general make people overconfident. If you get to doubting — with good reason — whether you're actually as entertaining and creative as you feel, that'll make you anxious.
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