101–110 of 120 posts
These medicines reduce the cravings for sugar. Is it possible that all of these beneficial side effects are just benefits from not abusing sugar.
These things do way way more than just appetite and craving suppression.
These medicines reduce the cravings for sugar. Is it possible that all of these beneficial side effects are just benefits from not abusing sugar.
retaglutide is the next gen (3rd) GLP-1 which is in phase 3 trials now. It is a triple antagonist (current are dual GLP-1/GIP). It adds glucagon, and apparently that comes with not only greatly increased weightloss, but also wicked sugar cravings. These things do way way more than just appetite and craving suppression.
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Does having uncontrollable weight gain help you get jacked? Being jacked and fat is tons of fun, better than being skinny.
In the same way that CICO (calories in, calories out) is a hard metabolic rule of weight gain, eating lot of complete protein and lifting heavy things is a hard physiological rule of "getting jacked" . It's conceivable that future drug discoveries could safely reduce the amount of lifting required. But the protein requirements will always remain.
Earlier quoted context omitted.
retaglutide is the next gen (3rd) GLP-1 which is in phase 3 trials now. It is a triple antagonist (current are dual GLP-1/GIP). It adds glucagon, and apparently that comes with not only greatly increased weightloss, but also wicked sugar cravings. These things do way way more than just appetite and craving suppression.
Interesting! how does that work though? I thought reduced sugar craving was part of how GLP-1s aid in weight loss as the paitent craves sugar less and thus eats less.
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The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great…
> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. I don't think that framing is right, from another study: * 17.5% maintained 75+% of their weight loss * 25% maintained 50-75% of their weight loss * 23% maintained 25-50% of their weight loss * 24% maintained 0-25% of their weight loss At least 75% (possibly more!) maintained…
A person cannot lose weight that fast normally, losing 70 or 100 pounds at 2-4 pounds a month is alot of time. But I was able to lose it and go from not being able to run, to being able to walk and run all day at festivals. Guess how it's easier to lose weight now...
I think alot of people don't understand how hard it is to exercise or lose weight while fat, just due to the join pain and muscles. Let alone shoes not being meant to support you. Losing that, it becomes alot easier to "just go for a walk", or work on cardiovascular health. I got on it after I went on a trip with a friend and walking for a few hours had me bed ridden the next day and he was like "Ya, I'm tired but I could walk all day if I had to", and he wasn't fit. Now I'm that person and can fit in a whole meal with how much I burn from walking/running.
I will say for the time I was on a GLP-1 at the end, it's amazing. It's almost the same effect as the other pills on appetite, but without the side effects. Phentermine and other stuff will make people manic, paranoid, or make your heart pop out of your chest. This type of drug is a godsend, and anyone who's committed will maintain the weight loss and live a healthier lifestyle.
Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…
There is large-enough consensus on this drug for its main use cases (treating diabetes and obesity), but more importantly for this conversation: it's actually quite common for drugs to get new indications after their initial one --- at which point, there might be a new, broader consensus on what the drug is good for. Clinical trials are designed to treat a very specific subclass of individuals; pharmaceutical compani…
>pharmaceutical companies very carefully choose that subclass in an attempt to help ensure the clinical trials are successful
You mean that they mainly choose middle class white males with degrees? It's not some racism, it's just an observation (which one may call a clinical meta-study of a sort), that this is the group that follows doctor's advice best of all thus making results the least noisy. Which in turns makes trials many times cheaper because doing otherwise would have required much larger patient groups to compensate for higher noise.
Going beyond that will be many *-isms at once, but google it up.
This is a major factor impacting quality of drugs. For instance, GLP-1 itself should be probably prescribed to Blacks starting with lower threshold BMI because they appear to benefit more from it in 27-30 BMI range, and are more susceptible to weight-related health issues than whites in these "overweight" ranges, and more likely to develop diabetes from it, and overall. Doing so would have increased overall society's benefits from GLP-1 a lot. But no one knows for sure because clinical trials almost didn't include them.
Earlier quoted context omitted.
In the same way that CICO (calories in, calories out) is a hard metabolic rule of weight gain, eating lot of complete protein and lifting heavy things is a hard physiological rule of "getting jacked" . It's conceivable that future drug discoveries could safely reduce the amount of lifting required. But the protein requirements will always remain.
Not really, CICO is overly simplified to complete pointlessness. It's all hormonal, if you want to gain mass you can take a myostatin inhibitor which is a class of drugs that have already been discovered. You can also eat protein and lift heavy but that's just another way of managing your hormones.
These are very new and untested in large populations, but from everything I've heard so far it seems they still won't magically make you gain muscle without lifting heavy things and eating protein. They'll just take the limiter off when you do that so you can gain even more muscle than you would otherwise.
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There are currently several hypotheses. Some say that it's just because it helps you lose weight, and obesity increases the risk of so many things. However while this is true, there are lots of examples where there are effects even when you control for weight loss. One of the more interesting theories is that it's down to their anti-inflammatory effects, because chronic inflammation is linked to so many conditions.
Aside from fat loss, my guess is that what we'll ultimately find is that the benefits of GLP-1 therapy are primarily due to reduced blood sugar and/or ketosis, either/both of which (along with fat loss) could contribute to improved mitochondrial health and lower chronic inflammation. That could in turn improve all sorts of symptoms, not least of which would be migraine and depression.
This is my guess as well. It's been eye opening correlating on/off GLP-1s, wearing a CGM (blood glucose monitor), and seeing how that data changes depending on what I eat and how that further impacts what I eat an hour or three later.
Tightly controlled blood sugar was life changing to me - and I wasn't diabetic or at risk to become so.
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Once you have proven to yourself you can eat less and lose weight, you believe you can do the same with other things like smoking. Makes sense
That's not how it works.
It could absolutely be a factor in the effectiveness.
Placebo is a highly effective drug.
I say this as an extreme evangelist of GLP-1s. Behavior modification and habit building appears to me to be a large part of it. Friends on it who have used to as a performance enhancing drug to change habits have generally stuck with newly developed habits even coming off the drug. Friends who used it as a magic weight loss drug largely returned to previous weights and poor health, even some maxing out the doses over time.
Earlier quoted context omitted.
The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great…
> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. I don't think that framing is right, from another study: * 17.5% maintained 75+% of their weight loss * 25% maintained 50-75% of their weight loss * 23% maintained 25-50% of their weight loss * 24% maintained 0-25% of their weight loss At least 75% (possibly more!) maintained…
If you look at obesity, it was a very stable problem until the 80s, when it suddenly skyrocketed across all age groups and both sexes. So unless we had some sort of mass infection of a discipline-destroying virus, another factor must be at work. Which, rather clearly, is food engineering.
So miss me with 'the thing you don't want me to have access to is "food"..'. No, the thing I want is for food to to back to being more natural and not tweaked to the microgram to elicit the highest hormonal response.
So no, I do not want to reduce access to "food".
> I don't understand this desire to say "people should suffer!" instead of taking something that helped them.
Cute strawman. I didn't say anywhere that people should just "tough it out". Food can be addictive just like alcohol or cocaine.
There is the nit that people using GLP drugs think those that control weight the normal way do it happily, resting on the couch or in bed smilingly as their stomach grumbles. We don't. We suffer too. It's not easy for us.