101–110 of 291 posts
I used to have the impression that the advance of LLM is peak human ignorance - we know how things work in a recipe like fashion, but not why. I even compared this with tribal rituals - follow a recipe with a probably misguided why. News like this gradually make me realize that this is how human wisdom have long been working, discovery and invention first, understanding later.
Earlier quoted context omitted.
I love to see some info like this and want to share my experiences. I'm a fan of small-molecule, well-tolerated, out-of-patent (cheap), widely available pharms like this in the class of "maintenance" and "enhancement" rather than "acute therapy" (although there is cross-over: i.e, have an acute headache? aspirin helps). Some things in my list right now: acetylcysteine, aspirin, metformin Besides aspirin, I don't take…
If you're interested in ashwaganda for its effects on GABA in the brain, you may be interested in these other molecules as well. So to compare Ashwagnda to Benzos/L-Theanine/Apigenin, here's how they work. Ashwaganda - has compounds called withanolides that bind to GABA receptors & increase GABA release. Very similar to how benzos bind to GABA receptors. L-Theanine - increases GABA release Apigenin - increases GABA a…
What's hormetic? I'll look it up. Actually I think I just meant things like: if you eat too much of any plant medicine, or take something too regularly, it's not going to be good, normally--especially for maintenance and enhancement... I mean, too much of something! :P ;xx ;p :)
PS - I meant ashwaganda in its adaptogen / stress lowering / cortisol response / cortisol lowering effect. Thank you! :) ;p xx ;p
Thank you again!! :P :) xx;p
Earlier quoted context omitted.
thanks, but no thanks
There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…
Please don’t project the irresponsibility of others onto those with self control, especially those with chronic conditions that induce extreme, long lasting, & completely debilitating pain.
annecdata: aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun) i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure…
Earlier quoted context omitted.
The body handles inflammations just fine, but you can actively help it to get it done more quickly. Doesn't have to be Aspirin though, chamomile tea and lots of other things work wonders, too.
Although HN is not a medical site, comments like yours need a disclaimer. Cause even the phrase “the body handles inflammations just fine” needs a it depends clarifier.
Tangentially, does anyone know how aspirin promotes bleeding? I've searched (and also searched nutrient depletions for aspirin) and I'm not really getting an answer.
annecdata: aspirin is pretty good as an anti-inflamitory and hence pain-killer. the reason i don't take it is that it irritates the stomach, and i have enough issues with my insides as it is (irritable-bowel syndrome - not fun) i currently use cocodamol (codeine and paracetomol) to control my arthritic pain, but it isn't doing so great. at the end of the day, if you really need pain control, you probably want a pure…
I have a friend who has suffered from something known as juvenile idiopathic arthritis since he was still a teenager, and he doesn't function very well without pretty decent doses of CBD for the past long while I've known him. I recognize legality issues are prohibitive in many parts of the world but if this is an option to you I would suggest trying this or anything else that takes the actual inflammation down inste…
Laboratory and clinical research have not confirmed any medical use for curcumin. It is difficult to study because it is both unstable and poorly bioavailable. It is unlikely to produce useful leads for drug development.
Earlier quoted context omitted.
Aspirin deprecated? It's one of the most useful and most widespread in use drug on the planet - for far more than "arthritis". It's the WD-40 of drugs. Ah, it's even in TFA: "Aspirin, which is a nonsteroidal anti-inflammatory drug, is one of the most widely used medications in the world. It is used to treat pain, fever and inflammation, and an estimated 29 million people in the U.S. take it daily to reduce the risk o…
Its been years since I've seen any bottles or packs of full dose Aspirin in a pharmacy here (Singapore). Seems like nowadays you can only get those low-dose tablets for blood thinning and they cost a fortune (compared to generic Panadol or what normal Aspirin used to cost)
Some research later, I found that it possibly interacts with certain bacteria that cause stomach ulcers and that these bacteria are more likely to be in poorly stored food. So, street food basically. This is a risk factor that would be much lower back home in Europe.
I wasn't able to get a definitive answer on this, but it's the best one I found so far as to why Aspirin is common in Europe and almost totally absent in Asia.
Earlier quoted context omitted.
They are very safe when taken as prescribed but quite dangerous when you don't read the directions. Although IIRC taking fever reducers when sick significantly increases how long it takes to recover. Those fevers are there for a reason.
> taking fever reducers when sick significantly increases how long it takes to recover I’ve also heard this, and always wondered whether it was true or a myth. I really have no idea. Any chance you have a reputable source?
A few jumping off points:
https://pubmed.ncbi.nlm.nih.gov/23664629/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703655/