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The FDA will likely approve the diabetes drug tirzepatide for weight loss
101–106 of 106 posts
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#102I'm sure this will have no long term side effects or risks! Is exercise + sound diet that difficult for people?
Clearly it is in the US. I think it's a generational lack of understanding and poor habits. From my perspective each generation of an obese family seems to get bigger and bigger, and pass on those non-existent or bad habits to their kids. If your parents aren't modeling exercise and good behaviors the only avenue you have to learn from is school and that's easy to get left behind.
On top of that you're marketed with the shittiest food all day, your school probably serves food where only things like pizza and burgers are palatable.
It's all really a shame because exercise and eating well clear your mind and make you feel better. Even if you're a healthy weight eating shitty and sitting all day does things to your mental health.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#103Disclaimer - I'm just a mere biochem grad who've taken some grad level courses in physiology so my question is coming from curiosity and healthy dose of ignorance. I took a cursory glance at the wiki page ( https://en.wikipedia.org/wiki/Tirzepatide ) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally cha…
Patients do indeed need the drug to keep the weight off. They have proven this. But that is not an issue at all. Individuals who have gained a significant amount of weight do not produce leptin, grehlin, and other related hormones in the same way that people at a normal weight do. Once you’ve put on a significant amount of weight you can’t just expand the size of your fat cells you make new cells entirely. Even if yo…
Do you have any data on how long these “path dependent” effects are measurable for?
I remember reading a study on the effect of obesity on sperm counts in men, which showed a significant increase in sperm counts for the men once they lost weight after a few months.
Sperm replace themselves more quickly than other cells in the body, but presumably the same normalization should occur in this case absent some sort of persistent self reinforcement mechanisms.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#104Disclaimer - I'm just a mere biochem grad who've taken some grad level courses in physiology so my question is coming from curiosity and healthy dose of ignorance. I took a cursory glance at the wiki page ( https://en.wikipedia.org/wiki/Tirzepatide ) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally cha…
Patients do indeed need the drug to keep the weight off. They have proven this. But that is not an issue at all. Individuals who have gained a significant amount of weight do not produce leptin, grehlin, and other related hormones in the same way that people at a normal weight do. Once you’ve put on a significant amount of weight you can’t just expand the size of your fat cells you make new cells entirely. Even if yo…
Individuals who have gained a significant amount of weight do not produce leptin, grehlin, and other related hormones in the same way that people at a normal weight do. Once you’ve put on a significant amount of weight you can’t just expand the size of your fat cells you make new cells entirely.
That's a good point I hadn't considered. Thanks!
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#105Drugs like Adderall don't mimic the hormones talked about in the article, right? I took Adderall XR once a day in college which completely suppressed my appetite and, combined with being a poor student that couldn't always afford lunch, I would frequently only eat one meal a day (either breakfast or dinner.) Since I graduated college many years ago, I also stopped taking Adderall but my sense of hunger has never retu…
I'm also one of those people who finds it more convenient to eat 1 meal per day when busy. It also started in my early 20s, but I've never been on stimulants. I got in the habit of eating irregularly in grad school which made it even easier to continue. I rarely have any appetite within an hour of waking up, and ive almost never eaten during this window. Not clear to me which is the cause vs effect.
I know some people who are on the opposite end and have problems functioning after missing lunch. None of them have ever intentionally fasted, though again it's hard to separate cause from effect.
What is clear is that different people's bodies form very different expectations surrounding food intake, and we are mostly unaware of this collectively.
Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss
#106Disclaimer - I'm just a mere biochem grad who've taken some grad level courses in physiology so my question is coming from curiosity and healthy dose of ignorance. I took a cursory glance at the wiki page ( https://en.wikipedia.org/wiki/Tirzepatide ) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally cha…
I think your concerns are appropriate, but if there are people for whom drug-free practices are too difficult and not working, it might be a good alternative. It's probably better than bariatric surgery.
It's also not necessarily either-or: maybe lower doses might be enough to get someone over a hump or something with exercise and other lifestyle changes. Or some dosing protocol in tandem with other things might allow people to go off the drug eventually. Or maybe not. But it's early and who knows what research will show. Having another option that actually works and isn't harmful is better than not having that option.