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The FDA will likely approve the diabetes drug tirzepatide for weight loss

nbcnews.com

71–80 of 106 posts

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#71
post #2

Note that weight-loss is relying of a side effect. It might be a wonder drug, or it might have issues due to how that side effect affects patients (loss of appetite, insulin levels, etc). I hope it's a clear aid for weight loss but some caution is appropriate.

Sadly it seems that these drugs will be used for vanity without much regard for their safety.

It still requires a prescription and, therefore, a doctor moderates usage and safety.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#72
post #49

Disclaimer - I'm just a mere biochem grad who've taken some grad level courses in physiology so my question is coming from curiosity and healthy dose of ignorance. I took a cursory glance at the wiki page ( https://en.wikipedia.org/wiki/Tirzepatide ) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally cha…

honestly, what is wrong with you?

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#75
post #49

Disclaimer - I'm just a mere biochem grad who've taken some grad level courses in physiology so my question is coming from curiosity and healthy dose of ignorance. I took a cursory glance at the wiki page ( https://en.wikipedia.org/wiki/Tirzepatide ) and it seems like it's working wonders on weight loss by targeting satiety. Weight loss still occurs when calorie out exceeds calorie input so it's not fundamentally cha…

I have issues with my appetite. I eat a lot. So my fix was to exercise a lot. Which worked out fine. But now my hip has a pretty severe issue causing me to go from ~1,500+ calories per day burn to about half. Add to that the fact that I sleep worse due to pain... So my appetite is even worse, as I eat to compensate the lack of energy because of my bad sleep. I want these meds, if only until I've had my surgery and ha…

Why do we accept it for alcohol but not for food? If someone could invent a drug for avoiding alcohol consumption, why wouldn’t an alcoholic use it?

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#76
post #67
post #59

Earlier quoted context omitted.

Many. For one the government can now collectively bargain for better prices. They can also subsidize the drug such that its available for everyone who needs it, not just those who have great insurance or who can afford to pay entirely out of pocket. Keeping your working population healthy has massive second order effects on the economy, it would be an investment paying for medical care. Where does this money come fro…

If the government is making the drugs how do they bargain for a price? And if the inefficiency of the government in terms of defense spending is any indication, I’m sure we’d be getting way less for our money than we currently do.

If the USPS ran like the DoD, the country would fall apart.

Government is capable of efficiency.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#77
post #73

I'm sure this will have no long term side effects or risks! Is exercise + sound diet that difficult for people?

Empirically, yes. Very few people who attempt to lose a substantial amount of weight via diet and exercise are able to lose the weight and keep it off over the long term. The latter part is the problem for most people.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#78
post #61

Earlier quoted context omitted.

Unfortunately it's really expensive to research and produce drugs and somebody's gotta pay for it. The rest of world isn't willing to so it looks like rich people's insurance is the one that will foot the bill which means lower income people have to wait. It sucks and it's a inefficient way to fund research but it's better than the alternative where no one funds this research and we (both rich and poor) never get the…

Pharma profits so far could pay for research thousand years into the future.

Pfizer could fund research for two thousand years at only 10 million a year?

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#79

Earlier quoted context omitted.

I have issues with my appetite. I eat a lot. So my fix was to exercise a lot. Which worked out fine. But now my hip has a pretty severe issue causing me to go from ~1,500+ calories per day burn to about half. Add to that the fact that I sleep worse due to pain... So my appetite is even worse, as I eat to compensate the lack of energy because of my bad sleep. I want these meds, if only until I've had my surgery and ha…

Why do we accept it for alcohol but not for food? If someone could invent a drug for avoiding alcohol consumption, why wouldn’t an alcoholic use it?

It exists. Naltrexone. Amazing drug.

Re: The FDA will likely approve the diabetes drug tirzepatide for weight loss

#80
post #33

Earlier quoted context omitted.

Unfortunately it's really expensive to research and produce drugs and somebody's gotta pay for it. The rest of world isn't willing to so it looks like rich people's insurance is the one that will foot the bill which means lower income people have to wait. It sucks and it's a inefficient way to fund research but it's better than the alternative where no one funds this research and we (both rich and poor) never get the…

Another alternative is the government funding this research and/or buying the drug directly. This is what was done for the government ordering 30 billion dollars worth of covid vaccines from moderna, pfizer, and j&j.

Governments already fund much of the basic science research needed to find new drugs. That isn't the issue. The real funding issue is with stage 3 clinical trials, which now often cost on the order of $1B each.

In theory we could nationalize the whole industry and have the government run all clinical trials. So the decisions on which drugs to develop would then be based on lobbying and campaign contributions. Would that produce better outcomes than what we're getting now? The government has a poor track record on picking winners.

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