Live data from Hacker News

Vitamin D improves survival in Covid-19 elderly patients

sciencedirect.com

101–110 of 112 posts

Re: Vitamin D improves survival in Covid-19 elderly patients

#101
post #47

The important factors for Vitamin D are that it's cheap to manufacture and has well known (low) risks. We have reasons to believe that it might help fight Covid, especially in deficient individuals, even if we do not have controlled studies. Making it freely available and recommended for anyone who doesn't obviously get enough already is a reasonable strategy. It might not work - the correlation may not be causal. Bu…

One could make a similar argument, but you then run up against a major WHO policy document on public health measures to combat influenza, which states: "Ten RCTs were included in the meta-analysis, and there was no evidence that face masks are effective in reducing transmission of laboratory-confirmed influenza." and "According to the GRADE approach, there was moderate quality of evidence involving >6000 participants…

Good thing it's not an influenza pandemic

Re: Vitamin D improves survival in Covid-19 elderly patients

#102
post #47

The important factors for Vitamin D are that it's cheap to manufacture and has well known (low) risks. We have reasons to believe that it might help fight Covid, especially in deficient individuals, even if we do not have controlled studies. Making it freely available and recommended for anyone who doesn't obviously get enough already is a reasonable strategy. It might not work - the correlation may not be causal. Bu…

Instead of lockdown, why don't Governments issue free Vitamin D to all households and at all pharamcies, all winter? The cost would be a few million - against tens of billions for lockdown.

They put it in milk and other products already just for health.

Re: Vitamin D improves survival in Covid-19 elderly patients

#103
post #93
post #31

Earlier quoted context omitted.

I think most places add it to milk. I supplement during the darkest six weeks of the year (which is starting very soon). It does seem like there could be a bigger seasonal push. Maybe not from the government but from somewhere.

I think this would be the best solution: to add it to the milk products during the winter! Most people would get it, there would be (almost) no public discussion about it and the immune systems would be strengthened. People not buying milk could still buy it like today!

This already is done year round. But there are a lot more vegans now.

Re: Vitamin D improves survival in Covid-19 elderly patients

#104
post #28
post #14

Earlier quoted context omitted.

Vitamin D can be bought without prescription and there is currently no shortage, so why should a country (government) distribute it? Anyone who wants some can buy some. Handing out free Vitamin D is like handing out free gym passes. It's not bad, but also not really a government's responsibility except for cases when people would benefit a lot but could not afford it at all.

I always find it odd that people take such a hands-off approach when it comes to things like Vitamin D usage, while at the same time cheerleading for governments to crack down hard on things like gyms, birthday parties, church services, elementary schools. Nothing is too extreme in the name of COVID, except that somehow distributing Vitamin D would be going overboard?

Right.. in my state weed and alcohol are essential and remain open but exercise, education, social interaction are now once again limited to your own home and we wonder why mental issues are sky rocketing. The latest order in my state made this week bans all indoor gatherings with people outside your home and it’s about 40 degrees F outside.

Re: Vitamin D improves survival in Covid-19 elderly patients

#105
post #93

Earlier quoted context omitted.

I think this would be the best solution: to add it to the milk products during the winter! Most people would get it, there would be (almost) no public discussion about it and the immune systems would be strengthened. People not buying milk could still buy it like today!

This already is done year round. But there are a lot more vegans now.

Vitamin D is added in Alpro soy milk and the Oatly oat milk that I drink in Sweden, along with vitamin B12 and calcium. It's all equal to the levels found in cow's milk. There are organic variants of the above that don't allow fortification, but I choose the fortified ones.

Re: Vitamin D improves survival in Covid-19 elderly patients

#106
post #30

Friendly reminder: vitamin D3 can affect sleep if taken later in a day. I tend to skip if I forget to take it before noon. Also, D3 without additional K2 may lead to calcium excess.

From what I googled I couldn't find evidence for Vit D causing sleep issues taken at night - I did find articles suggesting that taking with a meal helps absorbsion - https://www.healthline.com/nutrition/best-time-to-take-vitam...

While there are studies on 25-OH-D metabolism impacting melatonin production, I can only find studies done with Multiple Sclerosis patients [1]. There are also studies showing that LOW levels of 25-OH-D may have negative impact on sleep [2][3][4]. While I am unable to present scentific evidence, I would like to state that for me - personally - taking vitamin D3 in the afternoon has similar effects to ingesting caffeine. I have no reason to believe that I might be suffering from Multiple Sclerosis. Without evidence you are free to ignore it as a placebo/nocebo effect. YMMV based on age, ethnicity, sunlight etc.

The "take with meal" instruction is common with substances requiring fat for absorption/bioavailability. Dietary fat increases vitamin D3 absorption [5].

[1] https://pubmed.ncbi.nlm.nih.gov/23665342/ The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507736/ 25-Hydroxyvitamin D Concentration and Sleep Duration and Continuity: Multi-Ethnic Study of Atherosclerosis

[3] https://pubmed.ncbi.nlm.nih.gov/28652922/ The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331570/ Association between Serum Vitamin D Levels and Sleep Disturbance in Hemodialysis Patients

[5] https://pubmed.ncbi.nlm.nih.gov/25441954/ Dietary fat increases vitamin D-3 absorption

Re: Vitamin D improves survival in Covid-19 elderly patients

#107
post #65

Earlier quoted context omitted.

The only form of Vitamin D that matters is D3. If you are not getting that, you're just ingesting a toxin that is useless at best. You say this with authority (but no sources), but it does not appear to be true. D3 seems to be preferable, and more efficacious, but that does not mean that D2 does nothing. https://www.healthline.com/nutrition/vitamin-d2-vs-d3 https://pubmed.ncbi.nlm.nih.gov/22552031/ https://pubmed.ncb…

Vitamin D2 is produced in plants because they use that. Similarly, D3 is produced in animals because they use that. Supementation of D2 has no effect on how much D3 animals end up with. From your 3rd link: Total serum 1,25(OH)2D did not change significantly with either treatment (p>0.05, post-treatment vs baseline). From your second link: only 3 of 10 possible studies included in the meta-analysis were randomized, co…

Yes. Like I said. More efficacious. That doesn't make D2 "useless at best". Both D2 and D3 have metabolites that bind to the (human) Vitamin D receptor[1]. BTW both need to go through liver/kidney[2], D3 by itself is similarly "useless" otherwise.

[1] https://en.wikipedia.org/wiki/Ergocalciferol#Mechanism

[2] https://en.wikipedia.org/wiki/Cholecalciferol#Mechanism_of_a...

Re: Vitamin D improves survival in Covid-19 elderly patients

#108
post #47

The important factors for Vitamin D are that it's cheap to manufacture and has well known (low) risks. We have reasons to believe that it might help fight Covid, especially in deficient individuals, even if we do not have controlled studies. Making it freely available and recommended for anyone who doesn't obviously get enough already is a reasonable strategy. It might not work - the correlation may not be causal. Bu…

Instead of lockdown, why don't Governments issue free Vitamin D to all households and at all pharamcies, all winter? The cost would be a few million - against tens of billions for lockdown.

Because VitD might reduce mortality by 20% to pick a number, which without lockdown still leaves millions of Americans dead - while lockdowns aim to stop the exponential growth and (if adhered to) reduce the number of infections and deaths by 95%+...

Re: Vitamin D improves survival in Covid-19 elderly patients

#109
post #59
post #57

Earlier quoted context omitted.

>and they - as far as I can tell - do not explain why these people did not receive their normal Vitamin D supplementation Under subheading 2.2: "All residents in the nursing-home receive chronic vitamin D supplementation with regular maintenance boluses (single oral dose of 80,000 IU vitamin D3 every 2–3 months)," The comparator (not recent supplement) group was on a different schedule, and had received a supplement…

> Unless they were also testing these other interventions, that critique does not apply. How do we know they weren't? Since this is not a RTC, but rather an analysis of historical data, we don't know how much they divided up this historical data looking for correlations.

The general problem with this line of argument is that it's meant to be a critique of a statistical fishing expedition (sharpshooter fallacy). This study is clearly not a fishing expedition because vitamin D has been a topic of interest in coronavirus disease for months now with multiple studies conducted.

Re: Vitamin D improves survival in Covid-19 elderly patients

#110
post #38

The current discussion here seems to be about Vitamin D in general, and ignoring the study itself. In my reading, this study is weak evidence. This was not a randomized, controlled trial, but historical analyses of a natural experiment. In itself, that's not a problem: we can learn a lot from natural experiments. But I don't think this instance is much of an "experiment." As I understand it, all of the residents (96…

Meanwhile,

https://news.ycombinator.com/item?id=25133165

Which one is it?

Post reply on HN