Live data from Hacker News

Vitamin D improves survival in Covid-19 elderly patients

sciencedirect.com

91–100 of 112 posts

Re: Vitamin D improves survival in Covid-19 elderly patients

#92

Earlier quoted context omitted.

> as far as I can tell - do not explain why these people did not receive their normal Vitamin D supplementation. My understanding: each patient receives a bolus dose every 2 to 3 months. The intervention group had that date within 1 mo before diagnosis (or 1wk after) > Here, the "Intervention group" was defined as all COVID-19 residents who received an oral bolus of 80,000 IU vitamin D3 either in the week following t…

80000 IU seems a lot, that’s about 100 times the RDA! Not saying it’s bad just interesting...

For what it's worth, there's been a lot of speculation in recent years that the RDA is far too low. 80,000 iu is still a huge dosage though!

Re: Vitamin D improves survival in Covid-19 elderly patients

#93
post #31

Earlier quoted context omitted.

Same reason governments filter the water or remove lead from paint; just because knowledge is available doesn't mean all citizens can and will act on it, and sometimes lowering the barrier is all that's needed. Moreover, I'd argue older generations in particular are more susceptible to believing what the doctor says. Just having the research available and the vitamins on the shelf isn't going to have nearly the same…

I think most places add it to milk. I supplement during the darkest six weeks of the year (which is starting very soon). It does seem like there could be a bigger seasonal push. Maybe not from the government but from somewhere.

I think this would be the best solution: to add it to the milk products during the winter! Most people would get it, there would be (almost) no public discussion about it and the immune systems would be strengthened. People not buying milk could still buy it like today!

Re: Vitamin D improves survival in Covid-19 elderly patients

#94

Earlier quoted context omitted.

> as far as I can tell - do not explain why these people did not receive their normal Vitamin D supplementation. My understanding: each patient receives a bolus dose every 2 to 3 months. The intervention group had that date within 1 mo before diagnosis (or 1wk after) > Here, the "Intervention group" was defined as all COVID-19 residents who received an oral bolus of 80,000 IU vitamin D3 either in the week following t…

80000 IU seems a lot, that’s about 100 times the RDA! Not saying it’s bad just interesting...

About 100 times the RDA makes sense if you take it once every 3 months, i.e. 90 days

Re: Vitamin D improves survival in Covid-19 elderly patients

#96
post #40
post #30

Friendly reminder: vitamin D3 can affect sleep if taken later in a day. I tend to skip if I forget to take it before noon. Also, D3 without additional K2 may lead to calcium excess.

One more friendly reminder: If Vitamin D dosage is above 4000IU, same amount of Vitamin A should also be supplemented to avoid Vitamin A deficiency (e.g. eat liver). It's also antiviral, so it sounds like a good idea anyway. More from doctors successfully treating covid with vitamins: https://youtu.be/LwlTQ52Wdro

Doctors of "holistic" medicine. One of the people in that video is also a staunch anti-vaxxer.

So, broken clocks, and all that.

Re: Vitamin D improves survival in Covid-19 elderly patients

#97
post #47

The important factors for Vitamin D are that it's cheap to manufacture and has well known (low) risks. We have reasons to believe that it might help fight Covid, especially in deficient individuals, even if we do not have controlled studies. Making it freely available and recommended for anyone who doesn't obviously get enough already is a reasonable strategy. It might not work - the correlation may not be causal. Bu…

Instead of lockdown, why don't Governments issue free Vitamin D to all households and at all pharamcies, all winter? The cost would be a few million - against tens of billions for lockdown.

Because vitamin might make a difference but it's won't be enough to just willy nilly let people catch covid at will without any precautions. IF it was basically a cure as you're implying then it would have been found out a long time ago as the difference would have been obvious even without a controlled experiment.

Re: Vitamin D improves survival in Covid-19 elderly patients

#98
post #30

Friendly reminder: vitamin D3 can affect sleep if taken later in a day. I tend to skip if I forget to take it before noon. Also, D3 without additional K2 may lead to calcium excess.

From what I googled I couldn't find evidence for Vit D causing sleep issues taken at night - I did find articles suggesting that taking with a meal helps absorbsion - https://www.healthline.com/nutrition/best-time-to-take-vitam...

Re: Vitamin D improves survival in Covid-19 elderly patients

#99
post #54

Earlier quoted context omitted.

There's actually a couple dozen studies on Vitamin D's effects on Covid-19: https://c19vitamind.com/ Some are retrospectives some are randomized clinical trials. Vitamin D has a major effect on the immune system that is well documented. OP is right. Even if supplementation reduced the death rate by only 25%, the cost-benefit analysis says that it would absolutely have made sense for countries to issue free Vitamin D…

This lists 2 RCTs (related to Covid-19 + a few others for other infections). One is very small (16 people), the other is dubious, it seems to be the one that combines with hydroxychloroquine "standard of care". (I believe this was discussed on HN before.) It almost certainly won't reduce death rate by 25%. Very few medical interventions have an effect size that large.

> the other is dubious, it seems to be the one that combines with hydroxychloroquine "standard of care".

I believe you're referring to this one, the RCT run in a hospital in Spain, with a startlingly huge effect size:

https://www.sciencedirect.com/science/article/pii/S096007602...

It seems that giving all patients hydroxychloroquine and azithromycin was the policy at that hospital at the time the experiment was run, so the RCT didn't vary that between control and experimental groups; they just gave vitamin D pills to one group and not the other. Is there some problem with this?

Re: Vitamin D improves survival in Covid-19 elderly patients

#100
post #37
post #2

I am curious to know why countries didn't buy large quantities of vitamin D and distribute them to all people? Wouldn't that be cheaper and more effective than complete lockdowns, full hospitals, etc.?

Maybe the easiest way to get vitamin d out there would be to politely ask manufacturers to fortify butter.

You might run into the problem that it can be toxic at high doses.

In my anecdotal experience, there seems to be a huge variance in the amount of butter that people eat, among people who regularly eat butter.

Also, does it survive the heat of cooking?

Post reply on HN