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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#101

Post by raducu »

jokowueu wrote: post #94
oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have . I would like to offer some extra info . Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting There is also a new drug on the horizon that doesn't wor…

I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#102

Post by raducu »

oblib wrote: post #88
srik wrote: post #76

Earlier quoted context omitted.

IANAD. The glycerinate does have a better absorption rate but and taking over 300mg a day regularly apparently has the potential for side effects (beside those bowel effects) - at least that's what I've gathered looking into Mg supplements previously.

Yes, it's a trade off and she needs to adjust the doses down if she can. Right now she's in shit shape mentally after being ditched by her fiancé so hopefully time will help her get over that, but truly amazing how well and quickly the magnesium glycinate helps calm her down. Physically she's as strong as can be. She's a level II Crossfit trainer and stronger than me. We're going try transitioning towards getting the…

Has she checked her magnesium blood levels?

It might be that she's not actually deficient, but magnesium is a NMDA antagonist (afik) and the axiety relief might come from that.

I'm just saying that magnesium might be a temporary fix, but she might get magnesium "poisoned" (if that's a thing) and you should search for an actual drug that has the same mechanism of action as magnesium does, but something that doesn't build up in your system.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#103

Post by raducu »

gnulinux wrote: post #50
colordrops wrote: post #22

Earlier quoted context omitted.

As others have mentioned, it's the THC component that can cause anxiety. I have high anxiety and THC usually makes it worse, but that's just temporary. I find that THC is bringing subconscious worries and pains to the surface, and if I actively process them, then I come out of the high feeling extreme relaxation and peace, more than I ever got from pure CBD.

Just a data point. I dealt with anxiety my entire life, and too much weed absolutely destroys me but small amount of weed definitely calms me down. When I smoke too much weed, it really doesn't feel like my anxieties deep down are surfaces. It feels like my brain is making up new stupid things. To me, weed is a very strong sensory experience. When I'm too high it almost feels I'm hearing too much, feeling too much, s…

Another data point: I have anxiety and weed/hash reduce my anxiety, it helps a lot with falling asleep while I'm awake but I'm known to scream while sleeping under the influence; another time I was sound asleep near a friend who was snoring and his snoring woke me up and I was convinced he was in fact drowning in his own vomit and I slapped and shook him and tried to get him on his side, after I realized he was fine, I happily went back to sleep as if nothing happened.

I also had visual hallucinations, visual/auditory synesthesia once from a high dosage of hash, so I might be an outlier.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#104

Post by amvalo »

raducu wrote: post #101
jokowueu wrote: post #94

Earlier quoted context omitted.

I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have . I would like to offer some extra info . Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting There is also a new drug on the horizon that doesn't wor…

I have a mutation which results in impaired BDNF and I do suffer from anxiety; so far buspirone seems to work, but I was considering SEMAX/SELANK for the BDNF increase, do you know anything about that?

I can tell you it'll make your hair fall out.

And maybe make you 20% less anxious/more focused, but honestly it's hard to say... actually, in retrospect I never experienced acute anxiety when I was experimenting with it. Certainly worth a shot.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#105

Post by _carl_jung »

grahamburger wrote: post #85
clarityPhone wrote: post #84

Earlier quoted context omitted.

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

Interesting - I had assumed the opposite! I picked up a few different blends a while back hoping to address some (relatively mild) social anxiety and it worked well at first but later started giving me horrible anxiety (oddly only later that night - I'd take a small dose in the morning and be fine all day, then freak out from 1am to 4am.) Tried a bunch of different blends of thc:cbd with little luck, but I was sticki…

I think they have this the wrong way round. Indica is known for its relaxation effects. Couch lock isn't due to anxiety but relaxed passivity, and sativa strains tend to promote overthinking and paranoia in those (inc. myself) prone to it.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#106

Post by instakill »

clarityPhone wrote: post #84
oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

1) you got the 2 mixed up, it's indica that's the in-da-couch. Sativa is the brain-high.

2) there's little evidence to prove that sativa/indica strains affect your high. The curing, drying, growing of each individual plant alters the THC-CBD-CBG ratios way more than strain or species.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#107

Post by Gatsky »

jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

There will be proper controlled trials soon, there is no substitute.

However, it's worth noting that most complementary therapies actually do nothing - homeopathy is the classic example. Of course, we know many people find them helpful for a variety of reasons, but they actually do not have any physiological or pharmacological effect. CBD on the other hand is definitely a psychoactive substance, which may have side-effects. I think this actually makes it more likely a priori that it is a useful treatment. Put it this way, say we didn't know about CBD at all, if a drug company discovered CBD in some kind of drug screen, they would definitely test it and advance it into clinical trials.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#108

Post by camexp »

hrangozz wrote: post #28
spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

It wasn't until things were legalized that I had the option to try a 1:1 strain (equal ratio of CBD to THC) and I've found that to be a much better balance for me. The psychoactive aspects are still there, but less intense, more relaxing and without negative feelings. Kind of like sipping beer vs shooting tequila.

This is a perfect example of how prohibition doesn't work. When alcohol was illegal in the USA, the only drinks you could really get a hold of was whiskey, moonshine and other high percentage beverages.

When illegal, the dealers want to be the ones with the best (strongest) product on the market.

Once made legal, the lower percentage drinks became available such as wine and beer, and they became the best selling and most popular type of drink. Drink that doesn't smash them across the face by the end of the night.

The same will (and is) true in regards to weed legalisation, the powers that be will harp on about weed these days being too strong, and shouldn't be legalised for that very reason, yet it has been shown that stronger drugs is an effect of a ban on the sale of these products.

The sooner it is legalised, the better, as I will be able to go to a shop and have all the available information at hand to help me make the best decision for my anxiety requirements. Instead, atm, I have to go to a dealer, who sells all the finest buds, but I have nothing to go on other than look, smell, and anecdotal evidence from someone who's main purpose is sell all her flowers, not ensure her customer is getting the right product for her needs.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#109

Post by awelkie »

ejolto wrote: post #96
intricatedetail wrote: post #91

Earlier quoted context omitted.

People take cannabis to help them manage the effects of schizophrenia but corrupt media used to play it other way around. Cannabis causes schizophrenia! If there was justice in this world, then all the editors allowing this should rot in jail.

Dude. CBD is antipsychotic[1] and thus might help people with schizophrenia. THC is psychoactive [2] and should probably be avoided by people with schizophrenia. [1] https://www.ncbi.nlm.nih.gov/pubmed/22716160 [2] https://www.ncbi.nlm.nih.gov/pubmed/28492950

I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#110

Post by johnnyparker »

antoniuschan99 wrote: post #48

CBN is supposed to be used for sleep

"One of CBN’s biggest benefits is that it’s a strong sedative, making it effective as a sleep aid and anti-anxiety drug". Here's a writeup about the difference in CBN vs CBD - https://ministryofhemp.com/blog/cbd-vs-cbn/
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