Cannabidiol in Anxiety and Sleep: A Large Case Series • Hacker News Board

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#91

Post by intricatedetail » Wed, Jul 03, 2019, 6:32 AM UTC

oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

People take cannabis to help them manage the effects of schizophrenia but corrupt media used to play it other way around. Cannabis causes schizophrenia! If there was justice in this world, then all the editors allowing this should rot in jail.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#92

Post by JamesBarney » Wed, Jul 03, 2019, 6:54 AM UTC

oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

Just a heads up. The glycine(of the glycinate) might be helping just as much as the magnesium. Glycine is relaxing and theorized to help with schizophrenia. (through nmda signalling)

If you're interest in other supplements that have preliminary evidence for helping with schizophrenia are bacopa and sodium benzoate are maybe worth a try.[0][1]

- Obviously talk to your doctor about it. https://www.ncbi.nlm.nih.gov/pubmed/29397899 https://www.ncbi.nlm.nih.gov/pubmed/?term=bacopa+schizophren...

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#93

Post by agumonkey » Wed, Jul 03, 2019, 7:04 AM UTC

oblib wrote: post #89

agumonkey wrote: post #81

Earlier quoted context omitted.

What brand and kind of CBD do you use ?

It's high CBD content oil that's got a private label brand. I'm not familiar with the supplier, but the supplement store we buy it from is locally owned and very reputable. My daughter works for them on occasion. They also sell CBD buds and she says she likes those better than the oil.

So it's under the tongue intake ? or is it vaporized and inhaled ?

Does she feel other improvements as well ? eating, sleeping or else ?

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#94

Post by jokowueu » Wed, Jul 03, 2019, 7:28 AM UTC

oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

I'm am glad you are helping your daughter thought this . This disease is such a cruel thing to have .

I would like to offer some extra info .

Since you are looking for OTC . Both NAC and SACROSINE have a lot of great research when it comes to schezophrenia. It seems to work for some but not others.also new research into TMG (betaine glycine) is also interesting

There is also a new drug on the horizon that doesn't work on the dopamine receptors and has much less side effects than what's currently

SEP-363856 helps treat negative symptoms of schizophrenia such as Inability to experience pleasure, Lack of interest in relationships, Lack of motivation. 5HT1A and taar1 agonist

https://www.medscape.com/viewarticle/913348

MIN-101 - a ~20% BDNF increase. Treats negative symptoms of schizophrenia. 5HT2A and sigma2 receptor antagonist.

Min-101 has a targeted release of 2021/2022. After they have completed their 12 week phase 3 trial, they will do a 36 week phase 4 trial. SEP, should also be available sometime in those two years as well.

Hope your daughter finds peace

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#95

Post by INTPenis » Wed, Jul 03, 2019, 7:32 AM UTC

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

I'm anonymous on HN so I can tell you that some people go out of their way to grow special strains that have more CBD in them than they do THC.

One such strain I have experience with is CBD Kush and I know for a fact that it has helped someone with ADHD.

CHD Kush is supposed to have an equal amount of CBD and THC but is very easy to grow and get a good yield like 50-60g dry per plant.

But there are other strains out there I'd love to try like Charlotte's Web which is the most famous example.

People tend to maximize the THC because it's psychoactive but it also makes people anxious.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#96

Post by ejolto » Wed, Jul 03, 2019, 7:33 AM UTC

intricatedetail wrote: post #91

oblib wrote: post #62

I have some current experience with my adult daughter suffering with severe anxiety. I started looking for over the counter treatments and found studies that used magnesium glycinate successfully as a treatment and it has worked wonders for her. She takes a 300 mg tab and in 20 minutes she's completely calmed down. It only lasts for about four hours but the effect is amazing. The downside is it can cause diarrhea whe…

People take cannabis to help them manage the effects of schizophrenia but corrupt media used to play it other way around. Cannabis causes schizophrenia! If there was justice in this world, then all the editors allowing this should rot in jail.

Dude. CBD is antipsychotic[1] and thus might help people with schizophrenia. THC is psychoactive [2] and should probably be avoided by people with schizophrenia.

[1] https://www.ncbi.nlm.nih.gov/pubmed/22716160 [2] https://www.ncbi.nlm.nih.gov/pubmed/28492950

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#97

Post by 78dfshj4 » Wed, Jul 03, 2019, 8:26 AM UTC

oblib wrote: post #88

srik wrote: post #76

Earlier quoted context omitted.

IANAD. The glycerinate does have a better absorption rate but and taking over 300mg a day regularly apparently has the potential for side effects (beside those bowel effects) - at least that's what I've gathered looking into Mg supplements previously.

Yes, it's a trade off and she needs to adjust the doses down if she can. Right now she's in shit shape mentally after being ditched by her fiancé so hopefully time will help her get over that, but truly amazing how well and quickly the magnesium glycinate helps calm her down. Physically she's as strong as can be. She's a level II Crossfit trainer and stronger than me. We're going try transitioning towards getting the…

You can use Mag Oil as another way to get Mg into the body. Its basically Magnesium Sulphate aka Epsom Salts mixed with water and rubbed on the skin. If its really concentrated it will sting the skin, but dilute to reduce the stinging effect. Alternatively soak in a bath with Magnesium Sulphate. https://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/...

Any sulphate can be absorbed through the skin, so soaking in copper sulphate will get more copper into the body which is useful for all types of Collagen. Copper will also make smokers feel like they are smoking their very first cigarette, ie they will feel nauseous if they smoke within 30mins of taking a copper supplement. I wouldnt advise applying copper sulphate directly onto the skin though as it will debride the skin and is now only used by the US Military for cleaning extreme wounds.

Magnesium irritates the lower bowel hence the diarrhea, so if taken orally, its better to take little and often through the day rather than one big supplement for a day, and always take after eating because tablets breakdown in the gut and get into the blood stream quickly.

Magnesium is also used to make ATP (Adenosine triphosphate) which helps provide cellular energy so being superfit, her demands for Mg will be higher than a sedate person. Taking Potassium also helps the cells take up glucose, amino acids and other nutrients including magnesium whilst sodium makes the cells take up just water, so in a way sodium starves cells at a cellular level, which could help contribute to a variety of problems including anxiety. To get your daily potassium intake of 4.7grams, you would need to eat 11 large banana's a day. One sign you are deficient in Potassium is you crave sugary foods after eating, but if you supplement around >2g with potassium (chloride/bicarbonate) your sugar cravings will go.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#98

Post by 78dfshj4 » Wed, Jul 03, 2019, 8:37 AM UTC

hn_throwaway_99 wrote: post #59

whalesalad wrote: post #36

Earlier quoted context omitted.

The less you use, the more your body will become sensitive to the smaller amounts of it. Meaning, if you dose correctly, you can actually use less to achieve more. So yep, dosage is extremely critical with THC.

> The less you use, the more your body will become sensitive to the smaller amounts of it. Do you have any reference to back that up? I ask because I am genuinely curious. I haven't heard this before, and usually with most other drugs the opposite happens, i.e. you slowly build a tolerance that requires taking higher does to acheive the same effects.

Tobacco is very good at clearing things from the body, like drugs or caffeine. Smokers clear caffeine faster from the brain than non smokers.

Check out the P450 group of enzymes to find out how this works, part of the clearance rate is controlled by the liver becoming more efficient and altering your food and drink cravings.

Other foods/chemicals like grapefruit juice slow the metabolism of some drugs, so 2litres of grapefruit juice combined with 50Mg of viagra will see you visiting A&E with a 5hr priaprism, that has to be let down with andrenaline injections into the corpus spongiosum.

Generally if you want your illegal drugs to last longer dont smoke.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#99

Post by 78dfshj4 » Wed, Jul 03, 2019, 8:38 AM UTC

duncan-donuts wrote: post #39

hrangozz wrote: post #28

Earlier quoted context omitted.

It wasn't until things were legalized that I had the option to try a 1:1 strain (equal ratio of CBD to THC) and I've found that to be a much better balance for me. The psychoactive aspects are still there, but less intense, more relaxing and without negative feelings. Kind of like sipping beer vs shooting tequila.

This is the most exciting thing about legalization to me. If I could go buy high cbd strains with a manageable level of thc I’d be first in line. I don’t want to get super high on thc. I just want all of the other effects.

Less THC in the leaves, more CBD in the leaves.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#100

Post by 78dfshj4 » Wed, Jul 03, 2019, 8:45 AM UTC

mettamage wrote: post #3

Why I post this: I am trying to sleep but can’t (on my phone to not wake anyone). I was wondering whether CBD might help. The study is simply a discussion prompt. My query also found [1]. I wonder who else has some insight into CBD. Edit: since this comment is quite down the discussion thread I would like to promote another topic [2]. It is about creating wearables that are able to measure stress. Measuring stress [2…

https://honestmarijuana.com/cbd-vs-cbn/