Diet that mimics fasting appears to slow aging
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Diet that mimics fasting appears to slow aging
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Re: Diet that mimics fasting appears to slow aging
#2The paper in Cell Metabolism is here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)0...
Re: Diet that mimics fasting appears to slow aging
#3What was the research plan here? We want to investigate a diets impact on aging? What are the negative results then?
These are two extraordinarily complex, intertwined topics that to come up with a hypothesis like this on the limited evidence ends up appearing to be just a random search for correlations, terminating once you find one that has the right p value.
Re: Diet that mimics fasting appears to slow aging
#4What was the research plan here? We want to investigate a diets impact on aging? What are the negative results then? These are two extraordinarily complex, intertwined topics that to come up with a hypothesis like this on the limited evidence ends up appearing to be just a random search for correlations, terminating once you find one that has the right p value.
If you investigate enough diets: https://xkcd.com/882/
Re: Diet that mimics fasting appears to slow aging
#5What was the research plan here? We want to investigate a diets impact on aging? What are the negative results then? These are two extraordinarily complex, intertwined topics that to come up with a hypothesis like this on the limited evidence ends up appearing to be just a random search for correlations, terminating once you find one that has the right p value.
This builds on some earlier work where the Authors investigated Intermittent water fasting on Chemotherapy recipients and found that their immune systems regenerated better. This paper appears to have found a way to mimic some of the effects on their previous protocol with something that is safer to do. The earlier paper is here: http://www.cell.com/cell-stem-cell/abstract/S1934-5909(14)00...
Re: Diet that mimics fasting appears to slow aging
#6It worked (supposedly) in mice, not in humans. The title is misleading.
Re: Diet that mimics fasting appears to slow aging
#7Haven't they known this for a long time?
http://jn.nutrition.org/content/31/3/363.full.pdf
APPARENT PROLONGATION OF THE LIFE SPAN OF RATS BY INTERMITTENT FASTING
by ANTON J. CARLSON AND FREDERICK HOELZEL Department of Physiology, University of Chicago, Chkago (Received for publication October 4, 1945 )
Re: Diet that mimics fasting appears to slow aging
#8What was the research plan here? We want to investigate a diets impact on aging? What are the negative results then? These are two extraordinarily complex, intertwined topics that to come up with a hypothesis like this on the limited evidence ends up appearing to be just a random search for correlations, terminating once you find one that has the right p value.
There's pre-existing research on the effects of calorie restriction that have appeared to show effects indicating that they might be beneficial with respect to longevity, so it's very unlikely to have been a hypothesis they've just pulled out of thin air.
Re: Diet that mimics fasting appears to slow aging
#9The connection between longevity and caloric intake has been studied in mice:
http://www.ncbi.nlm.nih.gov/pubmed/3958810 [1986!]
"Mice from groups 3-6 [restricted intake] exhibited mean and maximal life spans 35-65% greater than for group 1 and 20-40% greater than for group 2. Mice from group 6 [most restricted intake] lived longest of all." Brackets mine.
Re: Diet that mimics fasting appears to slow aging
#10The paper in Cell Metabolism is here: http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)0...
Contents of the diet are on this PDF:
http://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(1...
The human fasting mimicking diet (FMD) program is a plant-based diet program designed to attain fasting-like effects while providing micronutrient nourishment (vitamins, minerals, etc.) and minimize the burden of fasting. It comprises proprietary vegetable-based soups, energy bars, energy drinks, chip snacks, chamomile flower tea, and a vegetable supplement formula tablet.
The human FMD diet consists of a 5 day regimen: day 1 of the diet supplies ~1,090 kcal (10% protein, 56% fat, 34% carbohydrate), days 2–5 are identical in formulation and provide 725 kcal (9% protein, 44% fat, 47% carbohydrate).