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Ask HN: What are the greatest discoveries in the last few years?

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21–30 of 241 posts

Re: Ask HN: What are the greatest discoveries in the last few years?

#21
While it's not really "great", the absence of new fundamental physics this century is certainly striking...

OTOH Quantum error correcting codes are pretty bananas. Won't be useful for a good while.

https://en.wikipedia.org/wiki/Quantum_error_correction

EDIT: the correct answer is that gene editing stuff though.

Re: Ask HN: What are the greatest discoveries in the last few years?

#22
post #18

Earlier quoted context omitted.

This means curing: Color Blindness, Liver Disease, Hopefully Cancers, Genetic Defects, MAYBE one day Aging?

More likely the first (profitable) applications will be: changing eye color, hair color, losing fat, changing height, changing skin tone. Billions in each market.

More likely, the first profitable applications will not have anything to do with editing the human genome, as bad been the case for every other technique useful for genetic engineering.

Re: Ask HN: What are the greatest discoveries in the last few years?

#23
post #18
post #16

CRISPR for gene editing: "Since 2013, the CRISPR/Cas system has been used for gene editing (adding, disrupting or changing the sequence of specific genes) and gene regulation in species throughout the tree of life. By delivering the Cas9 protein and appropriate guide RNAs into a cell, the organism's genome can be cut at any desired location." (From Wikipedia https://en.wikipedia.org/wiki/CRISPR ) Edit: Hear a recent…

This means curing: Color Blindness, Liver Disease, Hopefully Cancers, Genetic Defects, MAYBE one day Aging?

I would first want to see people accept GMO crops. Then I'll be willing to think of people going to the doctor to change their eye color.

Re: Ask HN: What are the greatest discoveries in the last few years?

#24
The revolution in biotech happening from the discovery of the CRISPR process will be as important as the semiconductor in the long run: https://en.wikipedia.org/wiki/CRISPR

Neural networks via deep learning started showing incredible results the last few years (after about 40 years of development) across a range of fields, including speech recognition, machine vision, and more. It's still early days, but combining reinforcement learning with neural networks looks like it will be very exciting too: http://www.nature.com/nature/journal/v518/n7540/full/nature1...

Re: Ask HN: What are the greatest discoveries in the last few years?

#26
post #20

Earlier quoted context omitted.

I'd argue that the discovery of Denisovans might be bigger than Neanderthal genes, but they're in the same ballpark. Modern sequencing technology has led to an explosion in discoveries about early human (and other organisms') evolution. Actually, I'd just put "rapid sequencing" right near the top of the list. When I started grad school (in 2003 if you must know), there was a feeling that it'd be very hard to get any…

> Now there's a plethora of technologies that are both faster and more accurate. Sorry to nitpick, but the inherent error rate of high throughput sequencing platforms is still higher than capillary sequencing. This is more than mitigated for by the massive throughput advantage though.

How fast can we sequence now? What are the error rates?

Re: Ask HN: What are the greatest discoveries in the last few years?

#27
post #18

Earlier quoted context omitted.

This means curing: Color Blindness, Liver Disease, Hopefully Cancers, Genetic Defects, MAYBE one day Aging?

I would first want to see people accept GMO crops. Then I'll be willing to think of people going to the doctor to change their eye color.

For some reason I believe that cosmetic gene modifications will be more readily accepted than GMOs.

Re: Ask HN: What are the greatest discoveries in the last few years?

#28
post #26
post #20

Earlier quoted context omitted.

> Now there's a plethora of technologies that are both faster and more accurate. Sorry to nitpick, but the inherent error rate of high throughput sequencing platforms is still higher than capillary sequencing. This is more than mitigated for by the massive throughput advantage though.

How fast can we sequence now? What are the error rates?

About 6 Gigabases per hour, somewhere in that ballpark. Probably something like the equivalent of the human genome project (which took >10 years and 3 billion USD in the 90s) every few days.

Error rates are in the region of 1 to 0.1% generally.

I've never really worked directly with capillary data but understand it's error rate in early bases is limited by the amplification step. Which would be ~0.0001% (1 in 10000).

That said there might be a coarse filter (based on signal intensity etc) that would identify a subpopulation of high-throughput reads which have a <0.1% error rate. But I don't believe I've seen that reported. I'd be interested in hearing from anyone who has thoughts on that though.

Re: Ask HN: What are the greatest discoveries in the last few years?

#30
post #5

This sounds more like an AskReddit post than AskHN... but I'd say printable organs, smaller and smaller computer chips, commercialization of space flight, possible warp drive tech(may get us there in 100+ years, lol not expecting anything soon).. anti-aging (expected to double or triple life expectancy by 2050.) etc...

I'd consider most of the things you listed to be inventions/innovations. Discovery, for me, is closely connected to uncovering of a new phenomena or an effect. And invention/innovation would be the use of it for some specific purpose.

Surely the techniques and logic used to empower such inventions and innovation had to be discovered by someone at some point. For every great new invention is their not usually some discovery made sometime prior which ushered it in? For things like smaller and smaller computer chips. I'd say that Moore's Law was discovered, not invented.
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