Earlier quoted context omitted.
You will never beat a tuned system without GC with a GC system because of all the instructions necessary to traverse references and such. Having lots of cores and lots of RAM just means you can eat the cost more easily. It just means you can afford to let the VM do the work instead of the programmer. Also, no matter how much RAM you have, cache sizes are more or less the same, and cache line misses hurt.
The pragmatic solution is to write the critical parts of the code either completely allocation-free or using some kind of automatic memory management. To write large amounts of boilerplate and non performance sensitive code using manual memory management is likely time that could be better spent elsewhere. Similarly, tweaking a compute intensive part of a CLR/Jvm/Python/ruby program to fix GC performance is probably…
Write the performance critical system that needs to do the bookkeepping. Then write the easy stuff on top of that.