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Ask HN: Do you take nootropics?

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141–150 of 223 posts

Re: Ask HN: Do you take nootropics?

#141
post #70

For those of you who do take them: Aren't you concerned by side effects and/or long term health effects? Not judging, just genuinely curious; I've looked into them but it seems the general consensus is that their effects, both short and long term, are not very well understood yet.

I use Armodafinil/Modafinil 4-5 times per week, cycling for a few days here and there.

I've considered a lot of others as well (e.g. *racetams - avoided on reports of 'brain fog' and a few of mental impairment - scary!). However, out of the dozens(?) I ended up considering, Modafinil was the only one I ended up deciding to try and ultimately take regularly.

I've read enough studies (and try to keep up to date) to know what our current knowledge about it is. In almost all of the studies, side-effects have been fairly standard (headaches, a few people getting sick, etc.). It's been used on-prescription for the past decade without seeing any uproar.

In the long-term, I consider the risk of unknowns worth the reward. Most evidence points to it being fairly safe, if not, that's a gamble I might pay for.

I drink alcohol to have fun, often to excess. I eat junk food. I actively choose to do a lot of things that shorten my lifespan for negligible returns.

If this little magic pill, which costs the same as a bottle of coca cola, makes me feel motivated and alert for 14 hours a day, I'm going to take it until I find a reason not to.

Re: Ask HN: Do you take nootropics?

#142
post #138

I've taken L-Theanine with my coffee for years. The effect is subtle, but it's remarkable - I just look back over the last few hours and realize that I was distraction-proof. I haven't dabbled in anything else because I don't really like the idea of messing with my brain chemistry too much. Theanine gets a pass because it's just an amino acid, is naturally present in green tea, and is considered extremely safe. I'll…

I feel the same way about small amounts of psilocybin.

Re: Ask HN: Do you take nootropics?

#143

I took piracetam years ago when I was considering a career change and prepping for the LSAT exam. I believe that its legal history is somewhat similar to ephedra... 10-15 years ago you could buy it over-the-counter or online, but since then it's been taken off the market in the U.S. Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potent…

A lot of the more effective nootropics like semax, phenylpiracetam, noopept and cerebrolysin were developed by Russian pharmaceutical companies and are sold as regular pharmaceuticals in Russia. Why is Russia so interested in developing brain drugs? A lot of studies with these drugs are related to fixing brain damage from alcoholism.

Re: Ask HN: Do you take nootropics?

#144
post #18

I've had interesting and unexpected results taking Lecithin supplements. There is a stimulating effect similar to caffeine or a B12 shot, and there is also a focusing effect where I could not stop fixating. I can have a tendency to day dream but not on Lecithin. It makes your train of thought very hard to derail. I still take it sometimes but not regularly. It hurts my stomach and can be a bit too much sometimes. As…

Only references to Lecithin as a supplement I found were Soy Lecithin, is this it?

Re: Ask HN: Do you take nootropics?

#145
I used to take a wide array of cognitive boosters during higher education and piracetam is one I know quite well personally. To make this short:

It works for some things (like reading for hours at a time) but it has made me sometimes feel "foggy-headed" and less productive/creative. The effects it has on my GI tract have been problematic at times (causing gas) and it tends to make my blood sugar crash at T+3. Plus with the massive amount of choline you have to take alongside the product, it became an inconvenience rather than an aid.

I would recommend sulbutiamine over piracetam if you want to "get things done".

Re: Ask HN: Do you take nootropics?

#146
post #12

Not a nootropic as such, but fuelling my brain on ketones rather the glucose has made an incredible difference in concentration and cognitive ability. (Ketogenic = High fat, carb restricted diet)

How large a difference? I'm willing to try anything that gives me the focus of Modafinil without actually taking drugs.

Depends. I find myself more alert for some stints of time while in a ketogenic state, but on the other hand, have difficulty falling asleep (as in, normal day I'm drop dead asleep at 11-12pm, while in keto, I'm sleepy (very sleepy, groggy) but it is common for me to be awake at 2-3am. Wake up times is the same.

Not sure what is best to be honest since lack of sleep brings a lot of problems by itself.

Re: Ask HN: Do you take nootropics?

#147
post #130
post #119

Earlier quoted context omitted.

Why no frozen meals?

Most commercially packaged frozen meals have lots and lots of sugar, salt and oils added to low quality (cheap) ingredients to make them palatable. Some people think freezing food destroys its quality, but I think that the evidence for that is weak and fails to regard the loss of quality that comes from keeping things in the fridge for another day. When I stopped eating ready meals I lost a kilo in a week, I believe…

Sugar and salt I understand. Do you have more info on the oils? Have not heard that before.

Re: Ask HN: Do you take nootropics?

#148
post #119

Earlier quoted context omitted.

Why no frozen meals?

For me, a lot of frozen meals and processed foods in general have insane quantities of sodium. Seriously, check the labels and make sure to do the math on what you would consider a reasonable portions (they like to play games with portion size to bring daily percentages down).

Other than water retention, are there any other reasons sodium is bad?

Re: Ask HN: Do you take nootropics?

#149
post #116
post #35

Earlier quoted context omitted.

>Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potential for a pharmaceutical company to patent and profit from it, then you can generally rest assured that it will be scheduled to require a doctor's prescription. For just about everything, the over-the-counter options consist of vitamins and quackery. So either blatantly break the la…

I have a weird experience with melatonin. It puts me out quickly, but I wake up about 4-5 hours later in a half drugged state. For the next few hours I'm awake but drowsy.

Did you try going back to sleep after you wake up?

Re: Ask HN: Do you take nootropics?

#150

I took piracetam years ago when I was considering a career change and prepping for the LSAT exam. I believe that its legal history is somewhat similar to ephedra... 10-15 years ago you could buy it over-the-counter or online, but since then it's been taken off the market in the U.S. Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potent…

>> So that I can work without having to blast music through $300 noise-canceling headphones (which itself impairs focus, but is the lesser of all evils)? Rather than listening to music, you can listen to brainwave entrainment audio (Neuro-Programmer 3 is a good program to generate these). The lack of words prevents distraction, and the audio can entrain your brain to whatever frequency is best for what you are doing…

>> So that I can work without having to blast music through $300 noise-canceling headphones (which itself impairs focus, but is the lesser of all evils)?

I have seen people mention noise-cancelling headphones in the context of noise and open offices. Don't anyone use noise cancelling ear muffs? I am sure listening to music 6-8 hours a day is not good for your ears.

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