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Ask HN: Do you take nootropics?

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Re: Ask HN: Do you take nootropics?

#111

L-Theanine. Recently went through an interview spree. Helps me get rid of nervousness and focus on solving problems. Naturally found in tea leaves but obviously in small dosage. Can't confirm side-effects but sometimes gives me headache if I drink beer on the same day, particularly IPAs!

If you get good quality sencha, especially the (somewhat pricey) Gyokuro, you get a high dose of L-theanine and an absolutely delicious taste. One of my favorite pleasures in life!

Re: Ask HN: Do you take nootropics?

#112
post #35

I took piracetam years ago when I was considering a career change and prepping for the LSAT exam. I believe that its legal history is somewhat similar to ephedra... 10-15 years ago you could buy it over-the-counter or online, but since then it's been taken off the market in the U.S. Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potent…

>Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potential for a pharmaceutical company to patent and profit from it, then you can generally rest assured that it will be scheduled to require a doctor's prescription. For just about everything, the over-the-counter options consist of vitamins and quackery. So either blatantly break the la…

Melatonin and DHEA are hormones and are OTC. But just because they're OTC doesn't mean they should be taken lightly. Hormones are highly regulated in our bodies and taking extra can cause decreased natural production.

Adrafinil is not OTC, it is unregulated. That means you can sell it in the "research chemical" grey market but not as a drug.

Re: Ask HN: Do you take nootropics?

#114
post #43

Earlier quoted context omitted.

MIT has a patent on doses less than 1 mg and some(not exactly >1 mg) higher doses can have harmful effects.

Source on the harmful effects? I have not seen any credible study showing any significantly harmful effects. Did not know about the MIT thing. That explains why it seems impossible to find melatonin in reasonable doses. It took me a long time even to find something as low as 1 mg pills here in europe (why would anyone ever want to buy 8 mg melatonin pills??)

It's a hormone so yes, taking it can have negative effects. It can lead to decreased natural production. You have to be careful with anything hormonal.

Re: Ask HN: Do you take nootropics?

#116
post #35

I took piracetam years ago when I was considering a career change and prepping for the LSAT exam. I believe that its legal history is somewhat similar to ephedra... 10-15 years ago you could buy it over-the-counter or online, but since then it's been taken off the market in the U.S. Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potent…

>Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potential for a pharmaceutical company to patent and profit from it, then you can generally rest assured that it will be scheduled to require a doctor's prescription. For just about everything, the over-the-counter options consist of vitamins and quackery. So either blatantly break the la…

I have a weird experience with melatonin. It puts me out quickly, but I wake up about 4-5 hours later in a half drugged state. For the next few hours I'm awake but drowsy.

Re: Ask HN: Do you take nootropics?

#117

I've been taking vyvanse(before that adderall) for the past 10 years. I wouldn't have been able to graduate from highschool without it, I can barely function at my job(devops) without it. I haven't noticed any long term affects, it definitely works though. It's scheduled so it's not easy to get but it definitely works compared to some of the more hit or miss OTC nootropics. I'm willing to answer any questions if anyo…

As a fellow devop, I say that you shouldn't need drugs to do your job. IF you have to stay that late all every day, its time to rip it all out and start again... to quote from drugs.com: "Lisdexamfetamine is a drug of abuse and may be habit-forming." But that said, you've heard these all before. To new users; Long term use usually requires higher doses, the longer you're on them the worse the withdrawl symptoms. The…

> As a fellow devop, I say that you shouldn't need drugs to do your job.

You need to learn about mental health and, in this case, ADHD. You can't just wish mental health issues away.

Re: Ask HN: Do you take nootropics?

#118
The replies on this thread are very surprising... It seems everyone has tried them!!

The question you should ask yourself is why you would need to take pills to alter your normal brain function in the first place? Do you really need to be more focused / more relaxed? Where does the urge of being more productive come from? What is your end goal? Is that goal really going to make you happier?

Re: Ask HN: Do you take nootropics?

#119

Not a nootropic per say but I've noticed a huge difference since focusing on my general health; 1) 7-8 hours sleep per night. 2) 1 hour of exercise per day (some days cardio, other days weights(focus on compounds; squat, deadlift, bench press, shoulder press, pullups, rows)) (for people thinking "I'm too busy to spend an hour of my day exercising". I think the productivity increase of clearing your head doing this ex…

Why no frozen meals?

Re: Ask HN: Do you take nootropics?

#120
post #35

Earlier quoted context omitted.

>Regardless, my experience was that its only value is the placebo effect. If a substance actually does anything real, and there is potential for a pharmaceutical company to patent and profit from it, then you can generally rest assured that it will be scheduled to require a doctor's prescription. For just about everything, the over-the-counter options consist of vitamins and quackery. So either blatantly break the la…

Melatonin and DHEA are hormones and are OTC. But just because they're OTC doesn't mean they should be taken lightly. Hormones are highly regulated in our bodies and taking extra can cause decreased natural production. Adrafinil is not OTC, it is unregulated. That means you can sell it in the "research chemical" grey market but not as a drug.

You have to distinguish hormonal regulatory mechanisms that are externally vs internally triggered if you're going to discuss decreased natural synthesis.

Oral testosterone? Pituitary measures it and says to the testicles, "we're good here" and testicles atrophy. Oral prednisone? Pituitary says to adrenals "we're good" and adrenals shut down cortisol production.

Melatonin, however, is externally regulated through blue light suppression. So taking it doesn't engage any feedback inhibition, it just increases blood concentration.

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