21–30 of 47 posts
Well if they do test this on humans, and if something goes wrong - they can easily fix it. Just apply a wetware update. Maybe we can even deploy wetware updates wirelessly soon. Just think of the possibilities. "Have you installed the Starbucks(tm) Wetware upgrade that makes you able to digest our latest drink, yet ?"
This perspective is interesting: "Many ethicists have accepted the idea of gene therapy, changes that die with the patient, but draw a clear line at altering the germline, since these will extend to future generations." Doesn't this imply that ethically you can alter your own geneline as long as from that point on you cannot have progeny?
Human genetic variation is so profoundly unfair. There is such a wide IQ range, such a wide physical development range, such a wide 'beauty' range. To think of condemning one extra person to be in the bottom of those ranges is painful.
What the hell can such a benefit be measured against ? The aesthetic objection of 'ethicists' ? (read: filosophers trying to answer unanswerable questions armed just with 'common sense')
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Btw: I am not sure that, given the possibility of writing genes, we'd know the right genes to alter. Just answering to the article on its terms
Can't express coherently how much the idea of "not going with this research 160 mph" irritates me. Human genetic variation is so profoundly unfair. There is such a wide IQ range, such a wide physical development range, such a wide 'beauty' range. To think of condemning one extra person to be in the bottom of those ranges is painful. What the hell can such a benefit be measured against ? The aesthetic objection of 'et…
And we know more about genes literally every day. We will start with small changes (remove defects). Then we will tune physical details (height, weight, strength, skin). Then we will turn to the serious stuff - IQ, longevity, disease resistance.
To complain that some children will suffer, is to ignore all the children that already suffer.
Earlier quoted context omitted.
When subcultures like furries or bronies get hold of it, things may get more than a bit odd.
Any genome edit large enough to make you look like a dog would most likely kill you, or at least render any embryos you may conceive non-viable. GENETICS IS HARD.
This article made me want to try human genome editing. It's obvious that given the possibility people are not going to be able to resist.
When subcultures like furries or bronies get hold of it, things may get more than a bit odd.
... Rumors are rife, presumably from anonymous peer reviewers, that scientists in China have already used CRISPR on human embryos and have submitted papers on their results. They have apparently not tried to establish any pregnancies, but the rumors alarm researchers who fear that such papers, published before broad discussions of the risks and benefits of genome editing, could trigger a public backlash that would block legitimate uses of the technology.
... But scientists don't yet understand all the possible side effects of tinkering with germ cells or embryos. Monkeys have been born from CRISPR-edited embryos, but at least half of the 10 pregnancies in the monkey experiments ended in miscarriage. In the monkeys that were born, not all cells carried the desired changes, so attempts to eliminate a disease gene might not work. The editing can also damage off-target sites in the genome.
Those uncertainties, together with existing regulations, are sufficient to prevent responsible scientists from attempting any genetically altered babies, says George Church, a molecular geneticist at Harvard Medical School in Boston. Although he signed the Science commentary, he says the discussion “strikes me as a bit exaggerated.” He maintains that a de facto moratorium is in place for all technologies until they're proven safe. “The challenge is to show that the benefits are greater than the risks.”
... Although many European countries ban germline genetic engineering in humans, the United States and China do not have such laws. Research with private funds is subject to little oversight in the United States, although any attempts to establish a pregnancy would need approval from the U.S. Food and Drug Administration. In China, any clinical use is prohibited by the Ministry of Health guidelines, but not by law.
Of note, an excerpt on a related blog (excerpted from a paywalled article: http://www.sciencemag.org/content/347/6228/1301.full ) ... Rumors are rife, presumably from anonymous peer reviewers, that scientists in China have already used CRISPR on human embryos and have submitted papers on their results. They have apparently not tried to establish any pregnancies, but the rumors alarm researchers who fear that such pap…
Sure its more effective to change DNA while its still building the scaffolding - after you're born its too late for some things. But that leaves a lot to be done.
Of note, an excerpt on a related blog (excerpted from a paywalled article: http://www.sciencemag.org/content/347/6228/1301.full ) ... Rumors are rife, presumably from anonymous peer reviewers, that scientists in China have already used CRISPR on human embryos and have submitted papers on their results. They have apparently not tried to establish any pregnancies, but the rumors alarm researchers who fear that such pap…
http://americanpregnancy.org/pregnancy-complications/miscarr...