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Ask HN: How would you solve mortality?

news.ycombinator.com

21–29 of 29 posts

Re: Ask HN: How would you solve mortality?

#21

May I ask why we need to battle mortality? People tend to forget our body's limitations and that all the extra years add to the end, not in the middle. Not to mention the implications it might have on reproduction. People wont want to have children and slowly our numbers will decline. Also this will bring up an issue depriving ourself's of new Isaac Newtons, Einsteins and all the other bright mind and great people wh…

a) mortality deprived us of the Isaac Newtons, Einsteins and all the other bright minds already

b) why would there even be a discussion on 'who deserves' to be immortal? is there currently a discussion on who deserves to live based on what they contribute to society? crime would still be crime, and dealt with as it's always been dealt with

c) let's distinguish between mortality based on aging and mortality based on other unforeseeable causes ( violence, accidents, etc. )

d) mortality currently binds us to our solar system, and humanities' possible ultimate demise

e) we are at a stage where human evolution has stopped. the way to push it forward is now through our own means

my question was rather related to the technical issue - as it is a technical issue. not if it's desireable or not; that's besides the point and has to be dealt with separately

Re: Ask HN: How would you solve mortality?

#22
post #5

use baculovirus to serially and temporally express telomerase and keep the telomere count between 3000-8000 for all cells in the human body. Then figure out some way to flush out senescent cells

Apparently there's some work happening now with mice, to activate a gene that selectively eliminates senescent cells ( from Google ) - but gene manipulation after birth is unfeasible, isn't it? What other ways could there be? RE: Baculovirus, have you seen any attempts at this?

Yes, plenty of labs use this regularly on mammalian cells and mice etc. Nobody has used it clinically though ...

Re: Ask HN: How would you solve mortality?

#23
post #21

May I ask why we need to battle mortality? People tend to forget our body's limitations and that all the extra years add to the end, not in the middle. Not to mention the implications it might have on reproduction. People wont want to have children and slowly our numbers will decline. Also this will bring up an issue depriving ourself's of new Isaac Newtons, Einsteins and all the other bright mind and great people wh…

a) mortality deprived us of the Isaac Newtons, Einsteins and all the other bright minds already b) why would there even be a discussion on 'who deserves' to be immortal? is there currently a discussion on who deserves to live based on what they contribute to society? crime would still be crime, and dealt with as it's always been dealt with c) let's distinguish between mortality based on aging and mortality based on o…

a)I understand it's a technical question. But as with every technical question, we have to ask what the changes will be on society.

b)Mortality gives way to other minds to step forward like Stephen Hawking and others. Would have been such a good thing to have an immortal Isaac Newton for a millennia? Would have he realised the the laws of physics outside of earth's standards. Could have an immortal Einstein refine his theories and change his mistakes and adapt to newer findings? Could have had a Stephen Hawking any chance to share his knowledge beside immortal Einsteins and Newtons?

c)It is a discussion about who deserves it. As for expensive treatments which aren't affordable by anyone in our society right now. We all now this. These treatments or solutions won't be free of charge. Only the rich will afford it. You know, money talks...

d)It's not only mortality that binds us to earth. It's our whole biological build up. Which fits only the life on earth. What about the warp drive, worm holes, etc... These aren't good enough for humanity to reach for the stars?

e)Also we don't have any clue about what effects it will have on the human body to live on another planet.

f)It is silly to say that evolution has stopped for the human race. We are biological creatures which can adapt to its surrounding as any other. But having immortality and not producing offsprings will actually lead to an evolutionary dead end. Having no genetic mutation will prevent the species to create natural immunity against diseases etc...

g)I only wanted to point out that maybe it is not the best thing to cheat death. It is natural. It's not a disease. Stop treating it like one.

As I said. As we are concerned about A.I., so should we concerned about this as well. Logic dictates to examine a possible solution from every angle as possible. Not to put ourselves and the whole humanity into a dead end.

Re: Ask HN: How would you solve mortality?

#25
I think it's something of a tragedy that sentient life-forms die before they're ready to do so, before they've crossed off the last item on their bucket list, so to speak.

Sure, "immortality" in humans would present a variety of potential problems, but new technologies often do. Should we not have created cars, planes, nuclear power, etc. because of the risks we foresaw? Let's deal with the issues as they arise, rather than use them as an excuse not to try in the first place.

How would I approach the problem? "All of the above." Follow all plausible and ethical courses of action to see where they lead. It's too early to tell which method(s) will be effective, but if something is physically possible in this arena I expect we'll try it sooner or later.

Re: Ask HN: How would you solve mortality?

#27
post #21

Earlier quoted context omitted.

a) mortality deprived us of the Isaac Newtons, Einsteins and all the other bright minds already b) why would there even be a discussion on 'who deserves' to be immortal? is there currently a discussion on who deserves to live based on what they contribute to society? crime would still be crime, and dealt with as it's always been dealt with c) let's distinguish between mortality based on aging and mortality based on o…

a)I understand it's a technical question. But as with every technical question, we have to ask what the changes will be on society. b)Mortality gives way to other minds to step forward like Stephen Hawking and others. Would have been such a good thing to have an immortal Isaac Newton for a millennia? Would have he realised the the laws of physics outside of earth's standards. Could have an immortal Einstein refine hi…

a) that's not how technology works, that's not how progress is decided. somebody goes out there and makes it

b) that's just an ignorant way of thinking. similar to the poster below who wouldn't want to live with an older generation of people because of their ignorance - which just shows his ignorance; it's not up to you or us to decide how long people should live or playing out 'what if' scenarios and wondering if humanity is better off because somebody died. it's pointless

c) any technology that is available to rich people becomes with the progress of time more affordable and available to the masses

d) if you die before you reach the next solar system, what's the point of starting the flight? see the fermi paradox and the great filter. mortality could be one of the great filters for interstellar expansion

e) that's... completely besides the point of this discussion

f) we are currently at the state quite complacent and well-adjusted to our environment. no big hardships, no predators - we're the dinosaurs now. what different strain of the homo sapiens would have to evolve now randomly to surpass the current strain? dinosaurs didn't evolve into highly intelligent beings, although they've been around millions of years

g) that's a complacent and dangerous "it's always been this way". cells stopping to reproduce themselves are a malfunction, and it can be technically solved; the same way as we can repair robots, machines or other electronics

mostly fears, complacency and wrong assumptions. taken into account, but not useful as they act as distractions and take attention from the topic - which was the technological hurdles of fixing the human robot

Re: Ask HN: How would you solve mortality?

#28
Over the years I came to the conclusion that mortality may be the only thing that ensures the necessary flexibility for changes and advancements in society by breaking up power structures. Otherwise the flaws which are genetically and socially woven into our existence would rise with the elites into structures that would be optimized over centuries to quell all possible changes.

A look at the history of long standing lines of sovereignity shows us what to expect. Abuses and vices, capital and resource concentrations that would squeeze the life blood out of the masses. Ask yourself if you would like to be a de facto slave forever. That would likely be your place if you are granted postponement of mortality as a normal worker.

For all the hopes for the better in a state without mortality, even now we have a lot of advancements that barely benefit the masses. Even within our mortal societies we have legal constructs like laws of succession, increasing abolition of inheritance taxes, benefits of funds and foundations that have non-mortality like effects on society as a whole. Namely concentration of capital. The results can be seen in the cities of the western world-quality of products, average living spaces, medical treatment efforts are all on decline. Despite all productivity advancements we have generally rising prices.

So in short, because of our nature we maybe need mortality to exist as advancing societies.

Re: Ask HN: How would you solve mortality?

#29
post #27

Earlier quoted context omitted.

a)I understand it's a technical question. But as with every technical question, we have to ask what the changes will be on society. b)Mortality gives way to other minds to step forward like Stephen Hawking and others. Would have been such a good thing to have an immortal Isaac Newton for a millennia? Would have he realised the the laws of physics outside of earth's standards. Could have an immortal Einstein refine hi…

a) that's not how technology works, that's not how progress is decided. somebody goes out there and makes it b) that's just an ignorant way of thinking. similar to the poster below who wouldn't want to live with an older generation of people because of their ignorance - which just shows his ignorance; it's not up to you or us to decide how long people should live or playing out 'what if' scenarios and wondering if hu…

a) the more we venture further into the unknown the more cautious we can get, and we should get. Even, if you say, that's not the way it is. It might be better. Not saying it IS better, but might be...

b) I just proven my point. Humans are ignorant bastards. You can't deny the fact that this will create massive problems in society.

c) Yeah, but during that time, wars will erupt and kill millions who already could have been saved. Lose money, lose the greed out of humanity and everything bad. Then we can talk about free immortality for everyone.

d) We are soooo far away from proper interstellar travel with technology, that putting a handful of people in a tube and sending them far away while the rest of us dies here whilst they're travelling. I still think we will find answers regarding how fast can we travel. What about huge colonisation ships, on which people can live for generations? The great filters are mostly speculations. Some stuff we look back on and go, 'Hey that was a filter. Thank god we survived it!'. And there are always more answers for one problem. Oh and you forget there might be another issue. Living in space during the venture. That is hard for the human body, even if you live forever. So unless you change into robot, which is not as good, because solar winds, radiation, etc... What if we let humans evolve into space life?

e) Maybe, maybe not...

f) That is silly again. Over the years much has changed in our body. Just go and have a look at old castles, houses in Europe. A few hundreds of years ago the people were much shorter. Our body structure changes and adapts, but so does everything else in us. We are still evolving as we speak. Maybe the environment for the dinos was a bit harsh. Humans couldn't have evolved in that. Not to mention live. That's why being a dino was they way to go. A lot of people agree that it is a freak accident, that we have such a calm few thousand years without any huge issues in climate and vegetation. Now it is better, because we can shape our surrounding. Of course this spirals down into us killing everything that moves and has meat, fur, tusks, whatever... Mother nature is not stupid, there was a reason why the dinos couldn't evolve but still they were the dominant species. And it would be foolish to say they didn't. Not every dino lived in the same prehistoric age at once. They evolved from each other. Only an alternative history would know what would have happened, if dinos remain here.

g) Ok, than why do we have organisms which live basically forever and we're not one of them? And why aren't these immortal creatures not the true rulers of Earth by now? I'm not a biologist, but I do see a relation here between the necessity of death and evolution. As we mix our DNA we create better and better offspring. Immortality kills the need for offspring.

This is not off-topic. It would have been off-topic for me to comment: ' Hey what about vanilla flavoured ice-cream? How the hell they do it!?'

Anyway I enjoy this argument. It wont hurt you get a bit out of your comfort zone. Sorry if I annoyed you in any way.

Oh and I would love to have a cyber-brain as they have it in the Ghost In The Shell world. If my body dies I could still transfer my brain into something else. Like a big robot or something, or just a jar. Maybe creating this kind of hybrid solution would be the answer. If we can continue with our current body to evolve, but have our brain picked out if we want to... Maybe that would help. And the human robot doesn't need fixing, it is good as it is and what it will evolve into. Stepping outside of it might be a better solution then fixing.

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