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Ask HN: How would you solve mortality?

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Ask HN: How would you solve mortality?

#1
Which current and future technologies would benefit fixing the human 'robot', and why is it currently not feasible?

E.g. would you approach it from the 'immortal jellyfish' perspective, from cell regeneration, 'transporting' into an earlier version, transfer of the mind, etc.?

Re: Ask HN: How would you solve mortality?

#4
post #3

http://calicolabs.com http://humanlongevity.com http://genopharmix.com http://sens.org http://buckinstitute.org

Do you have any information on their current status and their biggest issues/blockers?

What I'm wondering about the different approaches is if they could receive bigger breakthroughs by sharing / crowdsourcing their issues and getting a wider attraction / reach. E.g. sometimes the answers to a problem lie in another industry

Like e.g. the fold.it game helped decyphering the crystal structure of an AIDS causing virus in 10 days, while scientists were battling it for 15 years

Re: Ask HN: How would you solve mortality?

#5

use baculovirus to serially and temporally express telomerase and keep the telomere count between 3000-8000 for all cells in the human body. Then figure out some way to flush out senescent cells

Apparently there's some work happening now with mice, to activate a gene that selectively eliminates senescent cells ( from Google ) - but gene manipulation after birth is unfeasible, isn't it? What other ways could there be?

RE: Baculovirus, have you seen any attempts at this?

Re: Ask HN: How would you solve mortality?

#6
Transfer of the mind, definitely. Hardware independence. Plus possibility of backups. Even if your body is completely vaporized in a blast, you can come back if there is a backup of you.

Forget immortality through the extension of the biological life of the body; yonder lies folly.

Re: Ask HN: How would you solve mortality?

#7
post #4
post #3

http://calicolabs.com http://humanlongevity.com http://genopharmix.com http://sens.org http://buckinstitute.org

Do you have any information on their current status and their biggest issues/blockers? What I'm wondering about the different approaches is if they could receive bigger breakthroughs by sharing / crowdsourcing their issues and getting a wider attraction / reach. E.g. sometimes the answers to a problem lie in another industry Like e.g. the fold.it game helped decyphering the crystal structure of an AIDS causing virus…

See:

https://www.youtube.com/watch?v=V48M5j-6zdE

and

https://www.youtube.com/watch?v=jbYgza4NNk8

To name some of the top roadblocks:

- Cellular garbage collection

- Inner-workings of Mitochondria and cell death/apoptosis at the wrong time.

- DNA repair genes

- Telomerase production/use

Analyzing genomic pathways associated to these is key. Understanding why the expression of genes varies or decreases/increases at the wrong time is also key.

Being able to use Cogntive computing/biomicry/AI/Machine Learning etc to analyze the hidden connections and relationships between phytochemicals, genes, proteins, pathways and environment is the next frontier.

We're working on it and could certainly use additional crowdsourcing approaches.

Re: Ask HN: How would you solve mortality?

#8
We've proven we can increase the lifespan of nematodes by what is equivalent to 300 years in human lifespan. If we can at least make it 150, then we have a chance at 300 and if we make 300 we have a chance at 500 and so on.

We can then truly solve for space travel and populating other planets and we'll have lifespans that enable us to travel for extended periods of time - a Universal requirement for the human species.

Re: Ask HN: How would you solve mortality?

#9

We've proven we can increase the lifespan of nematodes by what is equivalent to 300 years in human lifespan. If we can at least make it 150, then we have a chance at 300 and if we make 300 we have a chance at 500 and so on. We can then truly solve for space travel and populating other planets and we'll have lifespans that enable us to travel for extended periods of time - a Universal requirement for the human species…

On a sidenote : It's interesting to see Elon Musk advancing into space travel, whereas Peter Thiel advancing into trying to defeat mortality. Those seem very closely related industries that clearly do benefit from each other.

Re: The Nematode lifespan; What happened to the C60 buckyballs diet? Apparently rats that underwent a specific diet of C-60 fluids had nearly double the lifespan ( 22-26months vs 42 months ) http://www.sciencedirect.com/science/article/pii/S0142961212...

Re: Ask HN: How would you solve mortality?

#10
post #7
post #4

Earlier quoted context omitted.

Do you have any information on their current status and their biggest issues/blockers? What I'm wondering about the different approaches is if they could receive bigger breakthroughs by sharing / crowdsourcing their issues and getting a wider attraction / reach. E.g. sometimes the answers to a problem lie in another industry Like e.g. the fold.it game helped decyphering the crystal structure of an AIDS causing virus…

See: https://www.youtube.com/watch?v=V48M5j-6zdE and https://www.youtube.com/watch?v=jbYgza4NNk8 To name some of the top roadblocks: - Cellular garbage collection - Inner-workings of Mitochondria and cell death/apoptosis at the wrong time. - DNA repair genes - Telomerase production/use Analyzing genomic pathways associated to these is key. Understanding why the expression of genes varies or decreases/increases at the…

Do you have any specific ideas of a massive road-block that would benefit from a Mechanical Turk approach? E.g. issues that would require an AI, but if split into a lot of tiny problems, that could be solved as a whole?
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