I did some LSD about 35 years ago. More than once. For a few days afterward it utterly knackered my ability to write good code, or do anything that required concentrated, logical thinking. Also, I felt like crap (think "bad mental hangover" without the horrible side-effects caused by alcohol). That said, it was a pretty interesting experience. I highly recommend it, just not habitually. Someone (Timothy Leary?) said…
That said, it is pretty tiring...