While I understand the sentiment behind this post, I think it misses one crucial point: It costs time, effort, and very smart people to build the "Bugati"-like system as they describe, instead of the current systems (that are more like "Toyotas", to name one).
I haven't seen the paper yet, so I can't be sure, but I think the numbers might ignore many factors: First, you need some kind of abstract, exchangeable storage (e.g., protobufs) to work with the data in many languages. Third, there's the file-system and all its intricacies. Fourth, it's unlikely that any compute environment will be dedicated only to one application (there's scheduling, resource management, and all that, which means there are hidden costs to doing network IO due to contention, protocol quirks, etc.). And finally, any realistic application is more than just "solving" the problem in the fastest way possible. Requirements change all the time, new features will be added, the code needs to be readable, understandable, maintainable, etc.
It's possible to do all the above AND be super efficient, but it requires a tremendous level of understanding of a system at all levels that it can be quite challenging, and frankly, with business requirements, it's probably not worth the time. If there's a framework that gives you abstraction but compiles to the fastest possible specific implementation AND makes a programmer productive, I would love to read up more!