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Scientists say they’ll soon extend life ‘well beyond 120’

theguardian.com

91–100 of 151 posts

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#91
post #77

Earlier quoted context omitted.

If people lived forever, why would they ever retire? I imagine you'd take a 5 year sabbatical every 20 years or so and you'd probably even head to school a bunch of times to change careers if you got bored of centuries of the same vocation.

Who is going to hire you? Try getting a job at 62 right now.

Who is going to hire you at 20, right now? It's a problem we have to solve for everyone.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#92
post #52

Earlier quoted context omitted.

It would be pretty interesting if you had more than 3-4 generations at a time (say a generation is 30 years, then 3 x 30 = 90). I think the significance of a generation is as you say: in human terms, it seems the vast majority of your personality and outlook is formed by age 30. If people lived to be 1000 years old, then you would have 33 different generations at once. At the very least, those 33 different generation…

>People already say that baby boomers have hogged wealth at the expense of their children and younger generations. I haven't investigated those claims in detail but it seems plausible. This generational warfare meme is pushed by, among others, Stan Druckenmiller: http://www.nakedcapitalism.com/2014/01/three-card-monte-gene... You'll note that they push both sides at once. Boomers are told that millenials are feckless…

I'm a boomer, and I just want to state I don't feel 'millennials are feckless and lazy'! I get so tired of every generation looking for fault in the new generation. As a kid--my father never stopped complaining about the Hippies, even though deep down inside he had the same values, but did what society dictated. I always knew he wanted more out of life than going to a job he really didn't like, and putting up with a partner who just complained. He died from liver cancer at 64. Yes, due to drinking. He was a good man and tried to rebel againts the system in little ways, but I always knew the life he kinda picked, or fell into is not the life ge really wanted. I rember as a child he once told me, he would probally like the effect of heroin if it wasn't so dangerous. He repeated that stement many times over the course of his life. Years later, I still wonder how such a convective man could even go to those dark areas? I am sharring too much? I just want to go on the record as I'm sick of the sterotypes(hippies, generation z,y,x etc., hipsters, all of them). While, I on the box. I wish society would stop judging me by what I do. I have never liked the obligatory "What do you do?". Maybe, it's just an American thing? When I used to go to clubs if the "wdyd" came out if a person's mouth; I just politely answered, and walked away. Sorry, about rambling. I'm just venting.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#93

I just hope such medical advances would be available to everyone and not just a privileged few who can afford it.

The target market is very, very large. That bodes well for prices, since the costs of R&D and red tape can be amortized across a huge number of people and long spans of time.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#94
post #73
post #52

Earlier quoted context omitted.

It would be pretty interesting if you had more than 3-4 generations at a time (say a generation is 30 years, then 3 x 30 = 90). I think the significance of a generation is as you say: in human terms, it seems the vast majority of your personality and outlook is formed by age 30. If people lived to be 1000 years old, then you would have 33 different generations at once. At the very least, those 33 different generation…

I've always wondered if the average human lifespan is somehow implicitly factored into interest rates. If people lived to 1000+ years old, a small investment made early in life could potentially balloon into incredible wealth given even relatively conservative investments. Obviously political and financial stability could have huge impacts too. I have to imagine multi-century-long held accounts would have an impact

People always realize too late that time is the most expensive thing on earth.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#95
post #51

I don’t want just to live longer, I want to live longer while in a relatively good shape. Because if we are to live 30 years more with the physique of a 90 year old man then what’s the point. If on the other hand I could have the physique of a 70 year old man while I’m 100+ that sounds like a good deal.

Well then good news! The people mentioned in this article are generally trying to slow or reverse the effects of aging, including the weakening of skeletal muscles.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#96
> the probability of a 25-year-old dying before their 26th birthday is 0.1%

It's probably significantly lower than that as well if you take out all the accidental deaths that occur in people's 20s.

On a more skeptical note, I'm very doubtful of any claims to predict timelines related to medical or technological advances. We've been trying for a long time and with much better funding to cure/treat things like AIDS and various cancers and only recently have we made significant progress on those fronts.

My general impression of modern medicine based on conversations with friends and family members in the medical field is that, while the cures are getting better, the best course of action is to take a conservative approach to life (avoid smoking, severely limit drinking, exercise and lift weights regularly, stay active, and keep using your brain), as this has much better odds of maintaining a high quality of life as you age than hoping modern medicine will be able to fix whatever's wrong with you.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#97

I can't believe no one thinks this is a terrible idea. Of course I , selfishly, would love to live longer but doing so on a large scale is almost guaranteed to be a disaster. While we're at it why don't we just solve aging, provide infinite food supply, and eliminate predation for deer. That would be a great idea right? No way that would have any negative side effects, right?

You are essentially also saying "I do not want to make more money because I'll have to pay more taxes"

Birds are also the only ones that should be flying.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#98

Earlier quoted context omitted.

Another important point is that the relation between children, their parents and the society they live in would be changed in ways that are hard to predict. See, the current assumption (or rather, the assumption that socially still stands but that is already shaken by the current lifespan augmentation) is that once a child is an adult, it won't be long before they will eventually see their parents either die (before…

I can see a post-labour future, where automation has eaten so many jobs, and improved our quality of life so much, that noone really needs to work, you can have a job as a hobby if you want, but most people don't. And as you point out, healthy elders won't retire. In a lot of countries there's talk of increasing the standard retirement age from 65, where it's been for many, many decades, which is a step in the comple…

I think that what we need so desperately bad is a complete database of what goods and services are needed and demanded in our society as a whole, and what is the cost, in a standardized and comprehensive form, of those goods and services, as they are currently offered, whether in the official, monetary economy, or as stuff people do, and if possible, data on the evolution of those parameters over time.

For example: people need to eat, and they do that much eating at the McD's, and this costs that many socio-dollars, and then eat that many TV dinners, and do that much cooking, with an estimation in socio-dollars of how much time it takes to cook vs. how much to stop by the McD's to grab a burger.

And, let me get controversial: what was the evolution of that global cost as the traditional, implicit people responsible for cooking (women) started working full-time, too.

See, that wave of feminism represents a moment where the distribution of labour, and the shape of it, changed rather dramatically. It's hard to get a decent outlook on the economic effect of that event, which makes it hard to devise some form of public policy that would, at the same time, help our society solve the problems that probably appeared as a result, and to help society make the most of this new workforce.

My wet econodream is that we realize that we collectively spend an absurd amount of cold, hard cash on feeding ourselves, and that we'd save that much cold, hard cash by having a bunch of government-owned "restaurants" simply giving away (within some reasonable limit) good but ruthlessly efficient (in terms of labour, value of basic ingredients, nutricious value, taste, and even general convenience) meals to, like, anyone, at any time.

But we can't take any halfway decent decision at all without data. Which we don't have.

Although it appears that it might be happening.

Slatestarcodex found that database of cost-effectiveness of various public health measures, illnesses and drugs, measured in some acronym that looks seductively close to the philosophical definition of "utility"

https://research.tufts-nemc.org/cear4/Home.aspx

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#99
post #90

Earlier quoted context omitted.

Valproate, valproic acid, and sodium butyrate affect histone deacetylase, which might help rejuvenate brain plasticity. See also: * http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2010.... * http://www.newscientist.com/article/dn24831-learning-drugs-r... * http://en.wikipedia.org/wiki/Malleability_of_intelligence

Valproate is used as an anti-epileptic and as a mood stabiliser. There are some risks of PCOS for women, but those risks have never been explained properly to me.

The connection that immediately leaps to mind is the role of dopamine in inhibiting prolactin—if you have a slight hormone production imbalance on the thyroid/pituitary axis, decreasing dopamine production (and thus increasing prolactin) could exacerbate it.

Re: Scientists say they’ll soon extend life ‘well beyond 120’

#100
post #9

Please hurry up. I want to live for thousands of years.

Good to see Peter Thiel on HN.

Peter Thiel is spending big money on this. If anybody else would like to be able to say the same -- adjusted for the amount of money you have, of course -- then these guys are doing some very credible research, and they take donations:

http://www.sens.org/

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