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What Is Aging? Most Scientists Still Get It Wrong

joshmitteldorf.scienceblog.com

131–137 of 137 posts

Re: What Is Aging? Most Scientists Still Get It Wrong

#131
post #66

Earlier quoted context omitted.

Is your claim as true for people who care about their health? The kind of person who has the dedication to do intermittent fasting probably has the dedication to do a fair amount of exercise.

I started intermittent fasting around a year ago, and usually I do do reasonable amount of exercise. I had a health review as part of my work three months after I started. I really wanted to stop, because the fasting was difficult (I was doing two days a week). While before I was fairly healthy, my blood pressure has always been a bit high, as with my cholesterol. After fasting they were both gone down to good levels…

IF is not necessarily calorie restriction, it's more caloric timing. You can use IF to optimize gaining lean weight (muscle mass) just as you can use it to aid weight-loss.

IF is about managing appetite mostly, as the hormone that plays a large role in driving hunger (ghrelin) is highly habitual; the more often you eat, the more often you're going to be hungry. So by reducing the time-window in which you eat, you reduce the window when you'll feel hungry, which can dramatically aid diet adherence.

But that's more the everyday form of IF. If you're on a eat-stop-eat type protocol and fast once or twice a week, you're probably using it to ensure you maintain a caloric deficit each week. You're bundling all your reduction in food consumption into one day a week instead of ensuring you're at TDEE-400 calories every day.

Re: What Is Aging? Most Scientists Still Get It Wrong

#132
post #120

Earlier quoted context omitted.

First few times is a bit tricky concentrating at work - actually I started feeling really high towards the end of the first evening. After two or three weeks its fine. Feels a bit more tired towards the end of the day - like you might after a long hike or something - pleasant tired, and want to go to bed an hour earlier than usual. I personally avoid exercise on the fast days, but some people swear by it (reddit has…

Did you normally get enough sleep before starting the fasting? You mention that you now get more sleep, and I wonder how much of a factor that is in improving your blood pressure and cholesterol.

Its only on the fasting days that I feel tired earlier, and sleep an hour more. (I used to get more sleep a couple of years ago, before I moved in with my GF - she wakes us up an hour earlier than I used).

Re: What Is Aging? Most Scientists Still Get It Wrong

#133
post #77
post #63

Earlier quoted context omitted.

The ones with diabetes are usually bred that way in order to study the disease. A friend told me about a strain of rats that is literally so prone to obesity they will start eating themselves if no food is available.

Sure...makes sense. Humans have very often resorted to cannibalism when faced with death-by-starvation conditions.

I meant that that one rat would literally start eating parts of its own body. Or that's what I understood from her (she was a biologist).

Re: What Is Aging? Most Scientists Still Get It Wrong

#134

Earlier quoted context omitted.

I couldn't agree with you more. We have a fundamental culture of constant growth. It is by definition unsustainable. My hope is that if we did manage to ward off death for a bit longer, we might transcend some of our flawed notions. Who knows? Maybe young humans are fools, and that's the problem.

I kinda take issue with the "infinite growth is unsustainable" notion. If 1 dollar = 1 natural resource then clearly, yes, growth is constrained. But it isn't. My example for this is clerical work. Banks (for example) used to employ vast rooms of clerks, who spent entire days performing simple, repetitive maths in double-entry ledgers to make sure the bank knew where all the money was. Now all of that is done by comp…

Derivatives and complex financial products now mean that no one knows where the money is, and seems to be a big part of the financial crisis. Here in Europe the banks are offering almost no interest on savings as a result. Looks like the US is the same.

>"Given that this is HN and frequented by legions of hackers trying to find problems to solve that create real value"

Looking at the list of YCombinator funded startups on the front page (Reddit, Airbnb, Scribd), none of them seem to be tackling the big issues of climate change, pollution, seas being over-fished, deforestation, lack of physical resources for a growing population. Sure they increase efficiency in some small area, but I don't see any that even address environmental issues.

You need to remember that the majority of the worlds population live on very little money, and don't have the comfy lifestyles that many of us in the west have.

Re: What Is Aging? Most Scientists Still Get It Wrong

#135

Earlier quoted context omitted.

Is your claim as true for people who care about their health? The kind of person who has the dedication to do intermittent fasting probably has the dedication to do a fair amount of exercise.

My response was a bit of a throwaway pointing out that humans and lab animinals have rather converged in our lifestyles. What is more of a problem is the observation that human ageing has slowed rather dramatically in an evolutionary short time. The concern is that we have evolved this slower ageing physiology via a few simple adaptions (the low hanging fruit) and these are not reflected in the animal models. The fea…

Thanks for your detailed follow-up! My apologies for only reading it now. I was always a bit sceptical of the fasting experiments being representative of humans, but I'd never looked at the specifics of it.

Re: What Is Aging? Most Scientists Still Get It Wrong

#136

Earlier quoted context omitted.

Is your claim as true for people who care about their health? The kind of person who has the dedication to do intermittent fasting probably has the dedication to do a fair amount of exercise.

Exercise and living a sedentary life are not mutually exclusive. Pretty much everybody on HN has to remain still for most of the day -- however much exercise they do.

Good point. As ever, things are more complicated than they might appear at first...

Re: What Is Aging? Most Scientists Still Get It Wrong

#137

Earlier quoted context omitted.

My response was a bit of a throwaway pointing out that humans and lab animinals have rather converged in our lifestyles. What is more of a problem is the observation that human ageing has slowed rather dramatically in an evolutionary short time. The concern is that we have evolved this slower ageing physiology via a few simple adaptions (the low hanging fruit) and these are not reflected in the animal models. The fea…

Thanks for your detailed follow-up! My apologies for only reading it now. I was always a bit sceptical of the fasting experiments being representative of humans, but I'd never looked at the specifics of it.

If it means anything I think fasting may help in humans - not by slowing ageing directly, but by improving glucose control. I would expect an increase in average life expectancy from intermittent fasting while having little effect on maximum life expectancy.
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