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McMaster researchers may have found a way to restore metabolism to youth levels

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Re: McMaster researchers may have found a way to restore metabolism to youth levels

#21
post #5

Sorry to be off-topic, but I was drawn to the story because of the McMaster reference and I bet some other Hamiltonians probably will be to. Would love to connect with any HN folks in Hamilton!

Mcmaster computer engineering student here.

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#22

So, I thought serotonin was basically the "happiness" hormone. Wouldn't inhibiting serotonin have side-effects like making them feel depressed or at least less happy? Can any biologists comment? EDIT: as a replier mentioned, it's discussed in the article.

That's pop-neuro-psych gibberish marketing talk--molecules aren't moods any more than motor oil is velocity. Also, synaptic serotonin is in a different compartment. But I was pondering about the link between SSRIs and weight gain.

But brain chemistry is inextricably linked to human moods. That's why we prescribe people psychoactive drugs. And why people take them recreationally.

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#23

Seems like we are trying to engineer a solution that is fundamentally a behavioral issue rather than mechanical. I do realize though that assuming we can reign in consumption socially is a non-starter at the same time though I think enabling high levels of consumption is the opposite of what we should be doing. That said, anything we can do to reverse aging I am all for, I just hope our consumption patterns can becom…

Fixing metabolic slowdown isn't going to end obesity or reduce the need for exercise, but it will level the playing field.

It's still going to require effort, for many people, to maintain a healthy weight and exercise enough. But it's hard enough to do that as it is; if you can turn off a defect that causes the body to pile on unneeded pounds of fat (that interfere with health, mood, and the ability to exercise) with age, then you should.

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#24

Seems like we are trying to engineer a solution that is fundamentally a behavioral issue rather than mechanical. I do realize though that assuming we can reign in consumption socially is a non-starter at the same time though I think enabling high levels of consumption is the opposite of what we should be doing. That said, anything we can do to reverse aging I am all for, I just hope our consumption patterns can becom…

Isn't the change in metabolism as you age mechanical?

You can argue that everything in the universe is mechanical, even electricity, if you look at a small enough scale.

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#25
post #5

Sorry to be off-topic, but I was drawn to the story because of the McMaster reference and I bet some other Hamiltonians probably will be to. Would love to connect with any HN folks in Hamilton!

Checking in from Platform 302.

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#26
Based on the findings of this article, the OTC EGCG should "restore metabolism to youth levels."

Using a decarboxylase or AADC[0] inhibitor like EGCG[1] found in green tea extract limits peripheral serotonin metabolism, especially if you're supplementing with serotonin precursors like tryptophan or 5-HTP to avoid heart-valve issues.[2]

See Examine.com's note in the 5-HTP article[3] and the associated citation.[4] 800mg of EGCG 2 hours prior to supplementation demonstrated decarboxylase inhibition.

[0] http://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxy...

[1] http://www.amazon.com/gp/product/B000MYW2ZA/

[2] http://www.ncbi.nlm.nih.gov/pubmed/15781732

[3] http://examine.com/supplements/5-HTP/#summary5-1

[4] http://www.ncbi.nlm.nih.gov/pubmed/11374875

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#29
post #5

Sorry to be off-topic, but I was drawn to the story because of the McMaster reference and I bet some other Hamiltonians probably will be to. Would love to connect with any HN folks in Hamilton!

'nother hamiltonian here. Hoping to start working at platform 302 a couple days a week, soon. emailable at jordan@jordandavis.ca

Re: McMaster researchers may have found a way to restore metabolism to youth levels

#30
post #5

Sorry to be off-topic, but I was drawn to the story because of the McMaster reference and I bet some other Hamiltonians probably will be to. Would love to connect with any HN folks in Hamilton!

Sure, email is in my profile
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