Many source formats eventually gain the capability to include other files (e.g. jade partials) or reference them in other ways (e.g. you can check the size of an image while you are generating a Sprite CSS fragments) as part of the build process and this is where Grunt or Gulp or any other naive build system will fail immediately. Specialized build systems can handle the dependency checking for particular build targets (e.g. Cmake for C++), but tup makes it extremely easy to have proper minimal re-builds with any kind of compiler.
There is also an automatic re-build mode that's triggered as soon as you save the source file in the editor and it's a joy to use in web projects.