Screen uses C-a as its "command" character. Unfortunately, C-a means "go to start of line" in emacs and terminals. The solution? In your .screenrc file: escape ^Ww This will default C-w as the command character.
Isn't C-w kill-region in emacs? I recently came up against this problem too, but what else to change it to .. ?
A screen within a screen gets ctrl-v, just because it seems mostly unused and is next to z on a dvorak keyboard :)
(And no, I don't ever nest them any deeper).