This is a lisp engine written in python - RPython, to be precise. It literally compiles the lisp code into python bytecode, which is pretty neat - sort of like clojure is for the JVM. https://github.com/pixie-lang/pixie/blob/master/pixie/vm/com... Perhaps not magical, but I like the effort (though lisp-as-shell has to contend with emacs first).
It also has a Jit engine inside it.