Earlier quoted context omitted.
1. Someone _has_ come up with the One True Layout System. It's just that most people like to pretend TeX doesn't exist or, when they grok the box-and-glue layout model, try to reinvent it from scratch.
Someone yell at me if I'm wrong, but isn't TeX designed for paged content? That means while TeX might work amazingly for paginated content, single page apps, or really any non-paginated content, is very much a screwdriver where a hammer should be used scenario.
I've come across a feature request for Firefox where someone proposed to use the Knuth Plass line breaking algorithm just for text layout, but they didn't get very much traction: https://bugzilla.mozilla.org/show_bug.cgi?id=630181