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This CEO is out for blood

fortune.com

81–90 of 105 posts

Re: This CEO is out for blood

#81
post #46

Earlier quoted context omitted.

Can someone help me on the technical aspects of the blood tests they've developed? On the specifics, I'm afraid nobody can for now. They have refused to peer-review their protocols and validation data, so their assays are essentially a black box. So far, incredibly, they have managed to get away with this thanks to a glaring regulatory loophole (as the article explains); but sooner or later they'll have to open up if…

Wouldn't it be fairly easy to determine their FP/FN figures just by sending them lots of blood samples with known composition? If it's a black box, use black-box testing methods.

Like some form of "mystery lab-testing". Brilliant.

Re: This CEO is out for blood

#82
post #45
post #38

Earlier quoted context omitted.

I think you're underestimating her intelligence and capabilities. Clearly she had the background and the initiative. There are super smart and dedicated people out there. She sounds like one of them. Beyond that, I'm not sure if the patent is absurd or not...but I definitely don't think its absurd for a 19 year old woman to write up and be awarded a patent.

No, I was meaning I find it highly unlikely she understood or could actually implement the technology behind her patent. A 19 year old, no matter how smart, is not likely to have a thorough enough background to understand all of the related technologies involved in this patent. This is a medical device, and has to be "done right", or people can be injured or worse. I don't expect even a top-tier CS student could pull…

Depends on how motivated the 19 year old was, and how much freedom they had to focus on what was important to them.

By the age of 14 or 15, most intelligent and motivated people have enough education to start learning advanced processes and systems. Say you start at 14, if you are focussed, by the time you are 19, you will have had 12,000+ hours of opportunity to develop expertise in your field. And Ms. Holmes sounds very capable (Learned Mandarin in her spare time as a teenager, as a result spent a summer at the Genome Institute in Singapore,etc, etc,...)

I would expect that there is a significant (if not excessively large) population of 19 year olds out there that can not only invent, and understand, but also design, and prototype advanced technological platforms of the same complexity identified in this patent.

We had a 13 year old in my Computing Science Undergraduate course at SFU who just absorbed and aced every math course he encountered, zero effort at homework or note taking.

Some people are capable of great accomplishments at a very young age, and strictly speaking, 19 is not particularly young.

Re: This CEO is out for blood

#83
post #55

Earlier quoted context omitted.

Seems like a rather sad state of Hacker News when there is so much doubt heaped on a woman's technical ability just because of her age, and the fact she was unlikely to have completed the relevant formal education. There is rarely an invention 101. Many people can teach themselves.

I think I should make it clear -- this is not a gender issue. Let's stop trying to make it one. It, perhaps, is a age issue, sure. I have my doubts that an 19 year old chemical engineering student would have enough technical background to implement: radios, embedded systems, various sensors, medical analysis algorithms, database usage, notifications systems, knowledge of cellular technology, agreements with hospitals…

Well, you'd be mistaken. There are people who learn 3, heck, even 10 times faster than your standard bright university student, in large part because they needn't wait for formal instruction. You have probably learned at this pace on certain topics.

Such people can defy the standardized logic of what's possible by a certain age.

For example, Howard Hughes:

Showing great aptitude in engineering at an early age, Hughes, Jr. built Houston's first "wireless" or radio transmitter when he was 11 years old.[5] He went on to be one of the first licensed ham radio operators in Houston, having the assigned callsign, W5CY (originally 5CY). [6] At 12, Hughes was photographed in the local newspaper, identified as being the first boy in Houston to have a "motorized" bicycle, which he had built himself from parts taken from his father's steam engine.[7] He was an indifferent student with a liking for mathematics, flying, and things mechanical, taking his first flying lesson at 14 and later auditing math and aeronautical engineering courses at Caltech.[5][7]

Philo T. Farnsworth:

Farnsworth excelled in chemistry and physics at Rigby High School. He asked his high school science teacher, Justin Tolman, for advice about an electronic television system he was contemplating. He provided the teacher with sketches and diagrams covering several blackboards to show how it might be accomplished electronically. He asked his teacher if he should go ahead with his ideas, and he was encouraged to do so.[13] One of the drawings he did on a blackboard for his chemistry teacher was recalled and reproduced for a patent interference case between Farnsworth and Radio Corporation of America (RCA).[14]

Re: This CEO is out for blood

#84
post #80

Earlier quoted context omitted.

You should not be questioning the patent based on the person but on the contents of the patent. I know some 19 year olds that would absolutely astound you with what they are capable of. One of the things this website has taught me is to completely overlook the age factor.

To implement something described in the article, it requires experience , not intelligence, nor age. It's the experience that is in question. There is a lot of radically different and unique technologies that would be required to be mastered in order to implement a medical device such as this, safely and reliably. Not to mention extreme business prowess to wiggle ones way into a tightly guarded community such as the…

> To implement something described in the article, it requires experience, not intelligence, nor age.

Well, there are people out there who have plenty of experience. People who have, between them, collectively hundreds of years of experience in the relevant fields. So why haven't they been able to do what she has?

Maybe because it was never really about experience, but about the unique combination of smarts, guts and drive that she has?

Re: This CEO is out for blood

#85
post #35
post #14

Earlier quoted context omitted.

I skimmed through the first part, but based on your comment I went back and read the article. > As a bonus, board meetings are also attended by the company’s de facto legal adviser at large, trial lawyer David Boies. Boies represented the DOJ in the Microsoft antitrust proceedings and Al Gore in Bush v. Gore. What an odd cast for a startup board. I wonder what connects all these people, other than all being high-prof…

Seems rather sad state of our Patent system here in the US where a 19 year old with no prior technical background, who was a Chemical Engineering student, a sophomore no less (meaning barely finished or finishing General Ed. requirements and just starting Major courses), can write and file for a highly-technical patent involving radios, sensors, embedded devices, and the like. > And we could put a cellphone chip on i…

I filed a patent at age 16; there are no laws governing how old you must be to file, and rightfully so.

While you may stereotype young people as being unready to write and file patents--and perhaps many are--at least some have developed the right skills and technical knowledge to do so.

Judge the patents on their own merits, not their authors.

Re: This CEO is out for blood

#86
post #28

So no one has mentioned this yet, but this article is actually the Fortune cover story. And I think very much deserved, not for most of the details mentioned in the article, but because of their pricing page: http://www.theranos.com/test-menu -- it's freaking cheap.

It's almost absurdly cheap. If your health insurance doesn't cover your lab tests, then it's probably cheaper to travel to their testing centers in Arizona, get tested and go back home than go to a medical lab near you and pay out of pocket.

On another note, I wonder why all except one of their testing centers are in and around Phoenix?

Re: This CEO is out for blood

#87

Can someone help me on the technical aspects of the blood tests they've developed? The premise appears to be that they take extremely small samples ("25 to 50 microliters") and run lots of tests ("as many as 70 different tests from a single draw") using "the same fundamental chemical methods". This compares with standard blood tests which require 2 orders of magnitude more blood ("numerous tubes of blood, each contai…

Microfluidics. It's been a thing since the late 80s. http://www.rsc.org/ej/LC/2009/b911553f/b911553f-f1.gif Here's an early paper to use as a root for citation-chasing: http://www.sciencedirect.com/science/article/pii/09254005908... Here's a conference that has been going strong for 7 years: http://www.microtas2013.org/general.html The technology has already been developed and proven in an academic setting. It's matu…

FTA, it seems she's front-running some approvals requirements and the sales / payola cycle by running a testing lab as well as developing the tests.

To IT people, this is counterintuitive. You don't vertically integrate, you go for a horizontal slice. Intel won by making chips, not making whole systems (like IBM did).

I guess vertical integration might make more sense in healthcare though, for regulatory and market reasons. I guess the market might be a bit more like IBM renting out mainframes than Intel selling CPU to OEMs. Also, making the tests cheaper (which is the main thing she's doing) might be unattractive to labs, if cost-plus pricing is popular - existing providers might not want to cut their prices.

Re: This CEO is out for blood

#89
post #28

So no one has mentioned this yet, but this article is actually the Fortune cover story. And I think very much deserved, not for most of the details mentioned in the article, but because of their pricing page: http://www.theranos.com/test-menu -- it's freaking cheap.

It's almost absurdly cheap. If your health insurance doesn't cover your lab tests, then it's probably cheaper to travel to their testing centers in Arizona, get tested and go back home than go to a medical lab near you and pay out of pocket. On another note, I wonder why all except one of their testing centers are in and around Phoenix?

Phoenix is the Wild West. There is very little regulation or oversight, generally.

Re: This CEO is out for blood

#90
What an amazing story. Best read of the entire week. It's 20 minutes well spent.

A look at their website (and the profiles they're hiring for) gives a clear idea of where she is going. You don't need iOS/Android developers, or ASIC/FPGA designers, or hardware and mechanical engineers, to support Walgreen's Wellness centers.

She's clearly going after the last mile. Blood tests for the masses. In your phone. No need for prescriptions, or visits to Walgreens.

This is way bigger than a $90 billion dollars blood test industry.

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