One trip about 2 years ago made me realize that I should not worry about things I can't control, and changed me from the bitter, angry person I'd become to the life loving happy person I used to be when I was young, in an instant.
Scientifically speaking, are you saying that this would be the result for most people? Steve Jobs, for example, famously took LSD but he certainly cared about controlling most things in his life, and sweated the details.
Anyway, I got a lot of insights that really changed my life for the better. Funny thing is that most of it is common knowledge, these things that are 'easier said than done', that then turn out to be just as easy done as said :)
(I can only talk from my own perspective of course)