Earlier quoted context omitted.
If you respect Manning, please stop saying "he" and "guy".
This is clearly something that we as a society are going to have to wrestle with. It seems reasonable to me that this person, having XY chromosomes and all the hardware that go with them, may be correctly referred to using masculine pronouns. There's something to be said for respecting the wishes of the individual in how they'd like to be addressed. But there's definitely a point at which that drifts off into absurdi…
I'll let you fill in the comparisons to widespread sexism, racism, and homophobia for yourself. Go back to the leaders of the American civil rights movement and tell them to let things "percolate through society" so they can know "where to draw reasonable lines".
[0] http://www.t-vox.org/index.php?title=Cisgender_privilege