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Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

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Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#121
post #2

Lest anyone be confused by that headline, there are 6 other nonprofits in the current batch. So there is a 7-way tie for 2nd nonprofit.

I have been at times vocal in opposition to the type of companies that YC has funded in the past few batches, as the possibility of them improving life quality for people that actually need the improvement seemed quite small, largely based on a prospect of trickle down technology, which turns out to be as likely as trickle down economics, in that it rarely trickles out of San Francisco. Not saying those start-ups wer…

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Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#122

Earlier quoted context omitted.

The betterment of the world as a whole?

That's great, but the job of investors is to make money, not to better the world, isn't it?

If you need a cynical money-driven motivation, it's more humans to sell things to.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#123
post #117

Earlier quoted context omitted.

Yes our overhead is far lower. Our other "trick" is that several members of our team are multi-talented. For example Dr. Herst can do tissue culture work, formulation development, analytical chemistry, and immunochemistry.

While I appreciate that it's possible to cut down the upfront costs with talented staff, it still seems that things like clinical trials will cost hundreds of millions of dollars (at least that's the price range I've seen for anti-malarial vaccination clinical trials) and still have a substantial chance of failure at later stage trials. It would seem difficult to raise that kind of money from other than big pharma or…

It is not unlikely that some developing country like India, Brazil or Nigeria could pony up the money and provide access to regulatory fast tracks if the research seems promising enough.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#124

Earlier quoted context omitted.

> I personally feel happy that this effect is increasing Well, it's all good until it isn't. If the priorities of a few people impact so many (including you) and you no longer agree with them, then what do you do? > I hope to be the part of this small group at some point. I think it's actually a shame that you'd need to be a part of the "small group" in order to have a voice. Ideally, we'd all have at least the capac…

> Well, it's all good until it isn't. If the priorities of a few people impact so many (including you) and you no longer agree with them, then what do you do? You have a good point here, but... > I think it's actually a shame that you'd need to be a part of the "small group" in order to have a voice. > It's actually harder for you to make it into the small group sans the blessing of the few who are in it. ... but I d…

>The "small group" I'm talking about is not a group of special people, either born into it or allowed to join. I'm thinking about a subset of humanity that actually gives a damn, and works towards a change.

Yeah, I think we're talking about two different groups. The group I'm talking about is specifically those with capital/wealth--in part, the "investor class" if you will. This group does materially dictate the world's various agendas/priorities.

OTOH, I would say that you're already a member of "your group" (i.e. the group that gives a damn), just by virtue of the fact that you seem to give a damn. So, when you mentioned that you hoped to join the "small group" at some point, I took that as an acknowledgment of my position: that is, giving a damn and having your own priorities is not enough, without the capital/access to actually do something.

>There's a popular meme here that "the solution must be political in nature, not technological"

I'd say legal in nature, not technological. And, that's purely a practical matter. That is, it's not that I'm overjoyed about the state of our legal system. It's more that I don't think it's practical to play technological cat-and-mouse with our own government and expect to win. So, IMO, if we don't at least attempt to constrain the government legally, then we've lost hope.

But, I digress. To your bigger point, yes, seeking legal redress does have political implications. And there's no doubt that we need to fix our politics, but again, I think the problems are one and the same: the few moneyed interests I mentioned dictate our agenda, in part through our politics. So, while our politics appear to be broken due to sheer incompetence, they actually are not. They simply serve an agenda that is not "for the people", while attempting to maintain the facade that they are.

>...will burn this planet down to the ground. I would love them to have the freedom and the equal influence over the world's priorities, but I also don't want my future kids to die a painful death because of a combination of stupidity and democracy.

Well said and I agree to some extent. Beyond mere politics though, I'm lamenting the access to power to all but a few. That is to say, there are certainly also many thoughtful, caring people in the world whose ideas/actions could help to shape it and make it a better place for all. In other words, it's not simply a world of a few moneyed people who know what's best for everyone on one side vs. a slew of completely ignorant, incompetent, malicious dullards on the other. There are many in the middle whose priorities also deserve the light of day. I would imagine that you and I, as well as many others who post here fall somewhere on that spectrum.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#125
post #63

This is going to be really inconvenient for all the people who say "sure, you are good at making photo sharing apps and dating sites, but you don't cure cancer or anything."

Yeah, lets wait and see how fast they get their $25M. Giiven that photo sharing apps can get billions of dollars just like that, if the Immunity Project will have to struggle for their $25M, I'm giving up on SV altogether.

Photo sharing apps get money from VCs. Why would you expect that VCs would fund a non-profit millions of dollars?

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#126

I'm trying to understand what if any overlap a pharmaceutical nonprofit has with any value YC could add, from the scale of funds required, to product advice, to business model - everything seems entirely out of the range of YC's expertise.

I think exposure and access to investors is a pretty big one. I also think that YC should be able to bring some of the 'startup culture' to a domain that has historically been very enterprise-y (perhaps for good reasons of heavy capital needs).

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#127
post #2

Lest anyone be confused by that headline, there are 6 other nonprofits in the current batch. So there is a 7-way tie for 2nd nonprofit.

Out of curiosity, how do you approach non-profits from an investment point of view? Is there some equivalent to equity? Is the goal to break even, or are you essentially just providing a large initial donation?

Really cool to see yc taking things in this direction.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#128

Earlier quoted context omitted.

Yeah... Anyone know how much YC is contributing and what they get in exchange? Some kind of ownership of the company? Do people taking part in the $482,000 fund raiser get ownership of the company? Why doesn't YC just donate money as part of the fund raiser?

They don't get anything. http://ycombinator.com/np.html

Seems strange that non-profits have to "pitch" to validate themselves. If they have a mission, and believe in it, why do they need a bunch of money from men in suits?

Looks like easy PR and Goodwill for YC. Reminds me of all the big banks who take out full-page ads every Christmas and send out press releases touting how they're helping society by taking part in a Christmas fund raiser.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#129

when are we going to start addressing the problem of overpopulation?

There's a lot of non-profits that aim to make birth control more wide-spread, too. Do you have any other ideas how overpopulation can be tackled by a startup with purely legal methods?

I believe that decreased child mortality and increased education/self-sufficiency for women are two of the big triggers for reduced birth rates in developing countries; in other words, increase the chances that the kids they have will survive to support their parents, and decrease the need for mothers to be supported by their children/possibly increase the opportunity cost to them of having children (although I don't think I've heard it described in that last way, it's just how it looks to me).

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#130
post #63

This is going to be really inconvenient for all the people who say "sure, you are good at making photo sharing apps and dating sites, but you don't cure cancer or anything."

God forbid the people doing the actual work would get the credit.
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