Earlier quoted context omitted.
That's great, but the job of investors is to make money, not to better the world, isn't it?
The job of investors is to do what they want with their money and make sure they have an alignment of goals with those they give their money to.
Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
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Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#52Earlier quoted context omitted.
I'm Ian Cinnamon, one of the members of the Immunity Project YC team. We have in fact developed the vaccine. We've completed 2 years of animal testing, and we have one final experiment to run before we start our Phase I Clinical Trials in humans. In order to test the efficacy of the vaccine in human trials, we go to Durban, South Africa, where HIV has a prevalence rate of ~15%. We dose a wide range of healthy volunte…
Ian- YOU developed the vaccine for HIV? Were you part of some team from a university? Or did some other company develop the real science and you are partnering with them? How can you offer everyone in the world a free vaccine for your crowdfunding target of only $500K? where does the money you raise go?
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#53From the FAQ: "But, there are certain spots on HIV that rarely mutate, and these are the same highly specific targets that controller immune systems already recognize naturally. Our vaccine trains your immune system to attack those weak spots so that the virus is crippled even when it mutates. In other words, our vaccine shows the prime targets to your immune system so that it does not have to waste time and energy t…
These cells begin to divide faster, and the children code for and generate the same antibody as the parent. This ups the amount of cells with that particular antibody, increasing the probability that the antigen will be targeted. They trigger inflammation to increase the flow of blood, letting more immune cells per second pass through scan the area (probably not helpful for aids, but for a cut, a splinter or a tumor that is fixed in place it is useful). They also release freestanding antibodies with the same binding profile that can disable viruses and trigger other immune cells to come slurp them up.
I think when they say they aren't taking an antibody approach they mean they aren't making an artificial antibody and just injecting it for passive immunity (sort of like injecting an immune system that can't do its own adaptation and upregulation)
The main thing with vaccines I am still confused about is what the difference between them and allergy shots is, and how do the two end up with opposite effects? I guess there is somehow a different reaction to a spike of something vs a repeated presence.
(Edit: never mind.. microspheres.. who knew?)
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#54Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues reproducing. Extending the human population, especially those of developing countries, only leads to more of the above. One day our children are going to say - "Cool, no more HIV, but what's a rainforest? what's a Rhinoceros? why can't we eat fish." Just saying.
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#55I'm all for this; more power to them. However, HIV/AIDS is already very preventable and had been on the decline for a decade or more. I'd rather see something like this effort, but for cancer. A disease that affects many more people. Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues rep…
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#56From the FAQ: "But, there are certain spots on HIV that rarely mutate, and these are the same highly specific targets that controller immune systems already recognize naturally. Our vaccine trains your immune system to attack those weak spots so that the virus is crippled even when it mutates. In other words, our vaccine shows the prime targets to your immune system so that it does not have to waste time and energy t…
The advantage of using microspheres is that the vaccine is now monumentally safer than previous gene therapy or other vaccine attempts.
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#57I'm all for this; more power to them. However, HIV/AIDS is already very preventable and had been on the decline for a decade or more. I'd rather see something like this effort, but for cancer. A disease that affects many more people. Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues rep…
So make it happen (seriously).
Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator
#58This is one of those times when you take a step back, reflect, and look at the big picture. However much excited I am about my project, I realize that the stuff these guys are working on hits all the right notes. And then some.