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Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

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Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#51
post #22

Earlier quoted context omitted.

That's great, but the job of investors is to make money, not to better the world, isn't it?

The job of investors is to do what they want with their money and make sure they have an alignment of goals with those they give their money to.

I didn't mean to say that they can't do whatever they want, or that they're incapable of helping the world. But if the investor does not expect his investment back, then that would make it a donation, which - as far as I can tell from the article - this is not.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#52

Earlier quoted context omitted.

I'm Ian Cinnamon, one of the members of the Immunity Project YC team. We have in fact developed the vaccine. We've completed 2 years of animal testing, and we have one final experiment to run before we start our Phase I Clinical Trials in humans. In order to test the efficacy of the vaccine in human trials, we go to Durban, South Africa, where HIV has a prevalence rate of ~15%. We dose a wide range of healthy volunte…

Ian- YOU developed the vaccine for HIV? Were you part of some team from a university? Or did some other company develop the real science and you are partnering with them? How can you offer everyone in the world a free vaccine for your crowdfunding target of only $500K? where does the money you raise go?

If you look at the fundraising page they have a budget but it looks like the $500k just pays for the next experiment it wont even get them to Phase 1. Microsoft Research gave them $1M to get this far.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#53

From the FAQ: "But, there are certain spots on HIV that rarely mutate, and these are the same highly specific targets that controller immune systems already recognize naturally. Our vaccine trains your immune system to attack those weak spots so that the virus is crippled even when it mutates. In other words, our vaccine shows the prime targets to your immune system so that it does not have to waste time and energy t…

I think they mean they train the immune system by creating an antigen, not an antibody, that mimics or is identical to the nonmutating antigen on the virus. Your immune system upregulates appropriate antibodies on its own through a feedback effect when certain cells (B cell?) that have randomly generated embedded antibodies on their cell membranes come across an antigen.

These cells begin to divide faster, and the children code for and generate the same antibody as the parent. This ups the amount of cells with that particular antibody, increasing the probability that the antigen will be targeted. They trigger inflammation to increase the flow of blood, letting more immune cells per second pass through scan the area (probably not helpful for aids, but for a cut, a splinter or a tumor that is fixed in place it is useful). They also release freestanding antibodies with the same binding profile that can disable viruses and trigger other immune cells to come slurp them up.

I think when they say they aren't taking an antibody approach they mean they aren't making an artificial antibody and just injecting it for passive immunity (sort of like injecting an immune system that can't do its own adaptation and upregulation)

The main thing with vaccines I am still confused about is what the difference between them and allergy shots is, and how do the two end up with opposite effects? I guess there is somehow a different reaction to a spike of something vs a repeated presence.

(Edit: never mind.. microspheres.. who knew?)

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#54
I'm all for this; more power to them. However, HIV/AIDS is already very preventable and had been on the decline for a decade or more. I'd rather see something like this effort, but for cancer. A disease that affects many more people.

Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues reproducing. Extending the human population, especially those of developing countries, only leads to more of the above. One day our children are going to say - "Cool, no more HIV, but what's a rainforest? what's a Rhinoceros? why can't we eat fish." Just saying.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#55

I'm all for this; more power to them. However, HIV/AIDS is already very preventable and had been on the decline for a decade or more. I'd rather see something like this effort, but for cancer. A disease that affects many more people. Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues rep…

So make it happen (seriously).

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#56

From the FAQ: "But, there are certain spots on HIV that rarely mutate, and these are the same highly specific targets that controller immune systems already recognize naturally. Our vaccine trains your immune system to attack those weak spots so that the virus is crippled even when it mutates. In other words, our vaccine shows the prime targets to your immune system so that it does not have to waste time and energy t…

Instead of using standard vaccine practices (a dead/damaged/live version of the virus) to train your immune system, we are using these synthetic entities called microspheres. They are made of the same material as internal sutures, and your body takes them up and is able to have a memory response. Check out this youtube clip of the microspheres in action: http://www.youtube.com/watch?v=0XKy9byo67w

The advantage of using microspheres is that the vaccine is now monumentally safer than previous gene therapy or other vaccine attempts.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#57
post #55

I'm all for this; more power to them. However, HIV/AIDS is already very preventable and had been on the decline for a decade or more. I'd rather see something like this effort, but for cancer. A disease that affects many more people. Actually, what I really want to see it a focus on stopping poaching, whaling, habitat destruction and ocean acidification. Even with all the disease, humans don't seem to have issues rep…

So make it happen (seriously).

I donate to campaigns that I think believe have a real impact. One of my favorites is http://thetashingainitiative.org/

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#58
post #44

This is one of those times when you take a step back, reflect, and look at the big picture. However much excited I am about my project, I realize that the stuff these guys are working on hits all the right notes. And then some.

Thanks, jjoe! We really appreciate your support.

Re: Startup developing HIV/AIDS vaccine is 2nd nonprofit accepted into Y Combinator

#59
post #55

Earlier quoted context omitted.

So make it happen (seriously).

I donate to campaigns that I think believe have a real impact. One of my favorites is http://thetashingainitiative.org/

Wonderful! Good on you for taking action.
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