It is extremely inconvenient that time is base-24 and base-60 while everything else in the metric system is base-10; it leads, for example, to a difficult conversion between the "meters per second" of the physics class and the "km/hr" of the highway. One surprisingly frustrating thing is that if you view a day as a million "instants" then an instant is actually a very human number, about the human reaction time or so; and a kiloinstant is a very human timescale too; 86.4 seconds or just shy of a minute and a half. We already know that when someone says "be there in five minutes" they mean 7-8; if they said "be there in five ki" they would be more accurate.
Fun things:
1. I wrote an HTML5 base-10 clock here with some togglable layers. Try out base-10 time: http://drostie.org/time/ . It's actually much easier than reading a normal clock because it's a digital readout, "8, 5, 6" rather than "two past a quarter after 8, that's 8:17." (It might not seem that way at first -- but that's because we spent long hours learning to tell time.)
2. For the exactly opposite view, that the number system should be base-12, see http://www.dozenal.org/ . It's actually a good way to work with numbers, and I've used the "counting on the joints/pads of your proper fingers" trick a number of times; sometimes you only have one hand free and want to count to something that's less than 48 (you can encode 2 extra bits with "hand facing up, hand facing down, hand facing up again, hand facing down again"; I've found it gets confusing after 4 or 5 of these though.)
3. I am very sympathetic to Feynman's "we don't need more units!" claim, but the reason we use various units is because we have different interests -- masses in eV/c^2 for example reflect someone who is interested in the atomic interaction energies (eV) of relativistic particles (c^2); energies in Kelvin reflect someone who is interested in how much they need to cool their experimental apparatus to see certain effects; energies in inverse centimeters reflect people who have spectrometers. Following this, I've tried to think whether the base-10 clock could be used to construct a set of "rational units" which would try to get the "human scale things" right while making all of these other units amount to a power-of-10 difference. I've not condensed these speculations to a final form yet but the speculations are themselves at: https://github.com/drostie/essay-seeds/blob/master/misc/rati... .