It isn't actually a "lack of understanding" - I was doing research into phage therapy over a decade ago, and the field has progressed since then.
There are however a number of problems with phage therapy, and this is from the perspective of someone who likes phage therapy:
- Phages are usually very bacteria specific, there isn't really a "broad spectrum" phage. The therapy used in Russia and Georgia is often a bespoke formulation for each individual patient. This is:
a. Really, really hard for the FDA to approve.
b. Expensive as all hell.
c. Involves keeping "banks" of phages around, and creating custom cocktails of them. This is, as mentioned, expensive as hell, and manpower intensive.
- Phage therapy is fairly novel in the West, due to some problems in the early days of phage therapy followed swiftly by the discovery of penicillin. It's an entirely different method of treatment, which means all the clinical knowledge doctors currently have is invalid, and has to be relearned. That's tough.
- There's no promise a bacteria has a phage associated with it, and synthetic phages are, at this point, a pretty distant prospect.
- When bacterial cell walls rupture, they create endotoxins. Endotoxins are bad - indeed, in the early experiments with phage therapy in the West, insufficiently pure phage solutions with endotoxins in them were responsible for some deaths. Right now, phage therapy is most often used in dire cases, where side effects like that are less of a thing. For a bad case of Strep throat? There's some serious clinical trials that need to be done.
- It's a hell of a lot harder to give someone a 14 day course of bacteriophages to take home than it is a 14 day course of antibiotics.
Phage therapy is a really fascinating field, and I think it has a lot of potential. But to say we shun them due to a lack of understanding, or acting like what the Russians and Georgians do is "utter sorcery" ignores a great deal of the research that takes place here. The real problem is, even while we struggle with resistance, antibiotics are profoundly superior as a general purpose drug. The reasons the Russians used them so heavily is because they had trouble getting antibiotics.
But seriously, "What about phages?" isn't exactly a new idea.