I've had colleagues from Nigeria, CER, S.A., and several other countries in Africa.
I don't think you'll find any resistance beyond the intrinsic difficulty of an H1B hire, and that might be complicated by the absence of a bureaucracy in your country that is as mature as some of those in Europe/Asia (Czech Republic, Ukraine, India, China). If you don't have material job experience yet, it's really unlikely that someone will put the expense into that hiring process to bring you on. My (non-expert) advice would be to try to go to school in the US and work under that visa or to build the relevant work experience at home, possibly contract work for US companies. Best of luck.