My problem with Firefox has always been with having the browser open for a long time (days) and running multiple tabs, including having an open Gmail window constantly.
By that point, Firefox is always sluggish and painful. Closing the browser the natural is a waste of time because it takes so long for the memory to free up, and killing the process altogether is the only thing that does anything to buy me some clock cycles.
I'd like to see the results of a long-term test of that nature.