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Sleep Flushes Toxins from the Brain

bbc.co.uk

71–80 of 98 posts

Re: Sleep Flushes Toxins from the Brain

#71

Earlier quoted context omitted.

Thanks for all the info! It seems possible that torturing animals for days on end could be fatal to the victim. I hesitate to suggest to try adding doses of sleep to this diabolic regimen, for fear it would be attempted.

>It seems possible that torturing animals for days on end could be fatal to the victim. yes, all the things we humans call science...

You're right. We humans should stop developing and testing medicine.

Re: Sleep Flushes Toxins from the Brain

#72

This appears to have an interesting implication for FFI [1], a mysterious genetic disease that causes complete insomnia in adults and results in death. The final stage of FFI is dementia. It turns out that the β-amyloids that are cleared during sleep according to this paper, are associated with certain types of dementia in the general population [2]. It also turns out that certain sleep disorders are dementia predict…

To expand on the dementia issue, poor lighting can lead to disturbances in circadian rhythm and issues with sleep. Fixing this may help with dementia. Further research needed in the area.

Sources: http://www.webmd.com/alzheimers/news/20080610/bright-light-i...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553247/

Re: Sleep Flushes Toxins from the Brain

#73

I always wondered about how split-brain theory would work into this... I mean there are stories of people with half their brain removed who are fully functional (I think? I can't find a source atm). I wonder what would happen if half your brain could be on/off and switch? Also you'd think that any mutation optimizing for time awake would have decimated the other creatures? I don't get how evolution has conquered ever…

The people who have had half their brains removed (Hemispherectomy) and are functional had it removed when they were very young and the other side wired to adapt. Depending on age of operation, there may be more or less significant impairments for life.

For humans with 2 healthy hemispheres, as far as I'm aware better imaging is revealing that split brain theory is only partially correct for many of the processes that were formerly thought to happen in one half only. Recent imaging has shown that the other half is still involved, albeit in a less widespread fashion.

Re: Sleep Flushes Toxins from the Brain

#74
post #57

Earlier quoted context omitted.

> "The brain ... must choose between two different functional states - awake and aware or asleep and cleaning up" As any lucid dreamer can tell you, there's also a third option--asleep and aware.

Not to mention hypnagogic / sleep paralysis - mind awake, body asleep.

Except both of these are rare occurences that last a short while - it would probably be very detrimental to have lucid dreams or sleep paralysis every night for months/years.

Re: Sleep Flushes Toxins from the Brain

#75

Awesome. One very (very very) small step closer to creating a pill to help the flushing process so we may sleep less, or not at all.

I'd be happy with a pill that speeds up the sleep/recovery process - it seems easier to achieve and it wouldn't go against millions of years of evolution...

Re: Sleep Flushes Toxins from the Brain

#76

This appears to have an interesting implication for FFI [1], a mysterious genetic disease that causes complete insomnia in adults and results in death. The final stage of FFI is dementia. It turns out that the β-amyloids that are cleared during sleep according to this paper, are associated with certain types of dementia in the general population [2]. It also turns out that certain sleep disorders are dementia predict…

is your third source accessible from anywhere that doesn't require an account? i'd like to read it.

Re: Sleep Flushes Toxins from the Brain

#78
post #76

This appears to have an interesting implication for FFI [1], a mysterious genetic disease that causes complete insomnia in adults and results in death. The final stage of FFI is dementia. It turns out that the β-amyloids that are cleared during sleep according to this paper, are associated with certain types of dementia in the general population [2]. It also turns out that certain sleep disorders are dementia predict…

is your third source accessible from anywhere that doesn't require an account? i'd like to read it.

Paste the URL into Google. It seems that if your referrer is Google, no paywall for you.

Re: Sleep Flushes Toxins from the Brain

#79

This appears to have an interesting implication for FFI [1], a mysterious genetic disease that causes complete insomnia in adults and results in death. The final stage of FFI is dementia. It turns out that the β-amyloids that are cleared during sleep according to this paper, are associated with certain types of dementia in the general population [2]. It also turns out that certain sleep disorders are dementia predict…

Is it known if there are ways to support the cleanup process?

I ask because due to allergies I have constant sinus congestions and as a result a very light sleep. On average I wake up (to the point where I'm consciously aware that I'm awake) 2 to 4 times per night, persumably due to lack of oxygen.

I'm noticing memory issues; and while the process may not be reversable, I would like to halt it or at least slow it down as much as possible.

Re: Sleep Flushes Toxins from the Brain

#80
post #54

I always wondered about how split-brain theory would work into this... I mean there are stories of people with half their brain removed who are fully functional (I think? I can't find a source atm). I wonder what would happen if half your brain could be on/off and switch? Also you'd think that any mutation optimizing for time awake would have decimated the other creatures? I don't get how evolution has conquered ever…

On that post about a bird that fly for 6 months in a row there were a discussion about the sleep in animals. Some of them are able to sleep alternating one half sleeping and the other aware of the environment. And there is speculation if that bird could sleep while flying. I think half brain awake is not enough to have a fully functional life. I also heard about people losing part of their brain and adapting to deal…

In the case of the bird, it may not need fully optimized brain to fly. So it might be acceptable to have reduced brain performance as a tradeoff for longer awakeness, especially if you could recharge under reduced performance and then go back to fully awake (and rested).
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