Earlier quoted context omitted.
Let me try to answer: Slow - as in average Top loads (on CentOS) staying between 1 and 2 pretty much throughout the day; closer to 2 rather than to 1, peaking ALL the way up to 10 and even beyond several times a day, for periods as long as 15 to 30 minutes. Storage engine: MyISAM
Do you have some other measurements? slow_log, queries without indexes, low key cache usage? Load is just one metric and can be very deceiving. Do you have any backup system which hits the disks at the same time, batch jobs, or something similar? Depending on your workload, "load" can vary - it just means the writes are being queued up. It's definitely not a good sign, but try to get more specific. I've seen servers…
Personally, the most important metric for us is average query response time.
Additionally as others have stated where you can use memcache or some other key/value store you should be working on implementing that.