Yes, this is called the Nash equilibrium strategy.
Let's say for all the possible hand/board combinations and betting patterns you evaluate all of them (with current computing power this is not possible) then you can take the line that maximizes your value assuming your opponent maximizes his. Then you both end up close to even over a long period of play.
But it's even more simple than that:
Nash equilibrium strategy says that you have to bluff 1/3 of the time on the river in a certain spot and have a highly valued hand 2/3 of the time.
It doesn't matter whether your opponent calls you or not. If he calls you too much, your value hands get paid off more often. If he doesn't call you enough, he loses too much to your bluffs. If the bet is the size of the pot, then he has to call one half of the time as part of his Nash equilibrium strategy to not get exploited. If he deviates, he will lose to the bot in the long term.
And since this is limit it's actually very simple. Bet sizes in regards to the pot are tiny (1/5 to 1/10 of the pot) and there is no having to choose the bet size or allowing for players to overbet the pot (make a bet larger than the pot)
No limit is a much bigger challenge than limit for computers, because a small edge in limit is too hard to exploit since you'll get tired of exploiting a computer for pennies per hand