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High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

princeton.edu

11–20 of 128 posts

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#11
> A Princeton University research team has demonstrated that all sweeteners are not equal when it comes to weight gain: Rats with access to high-fructose corn syrup gained significantly more weight than those with access to table sugar, even when their overall caloric intake was the same.

I have my suspicions about HFCS, but what's not clear from the way this was written, and I suspect is the kicker here, is the access to line. Is it the same calorically balanced diet PLUS sucrose water or HFCS water, or is it the same calorically balanced diet INCLUDING sucrose water or HFCS water. The difference between the two of those is massive, and I would bet it's the former not the latter.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#12
post #3

Stop giving out corn welfare to corporations and problem solved. It's the ONLY reason why it's so heavily used. Corn syrup and ethanol - two massively damaging products of a completely corrupt system that everyone refuses to change because of massive profits off taxpayers.

Another control on this is the Overall Allotment Quantity of sugar, which is the USDA-regulated quantity of sugar which can be sold in any year. If you have too much sugar to sell, you'll have to store it or dump it. This is to keep sugar's price high.

https://en.wikipedia.org/wiki/Overall_Allotment_Quantity

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#13
post #2

I don't understand the mechanism here. I thought sucrase, the enzyme that breaks down sucrose (table sugar) into 1 fructose and 1 glucose (same as HFCS), acted almost immediately -- at least on the timescale of nutrient absorption. Is it just short circuiting our sense of satiety? Maybe the raw fructose makes things sweeter and stimulates reward centers better? I wonder where honey falls in all this since it has high…

You sound like you are a paid shill. I know that you aren't, which disappoints me further, because I'd like to think that people are capable of educating themselves instead of spreading misinformation. On your first paragraph, pondering whether sucrose breaks down into fructose and glucose immediately: No, it doesn't. HFCS makes sugars available to the bloodstream sooner, causing larger swings in overall blood sugar…

My that was uncivil.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#15
Is there actually a published, peer-reviewed study available from this? This just seems like an in-progress summary. Additionally, as another poster commented, this is still correlative, not causative.

HFCS might be indirectly responsible for weight problems, but that's only because of its prominence, low price, and calorie dense-ness. Not some voodoo reason as this article states and as many believe.

Try this: http://examine.com/faq/is-hfcs-high-fructose-corn-syrup-wors...

The experiment's conclusions don't make sense either. There are dozens and dozens of studies showing ONLY net calorie intake is what is responsible for weight gain or weight loss, not the contents of what they eat: http://examine.com/faq/what-should-i-eat-for-weight-loss.htm...

So for the study to refute the conclusions we have arrived at today would be quite the breakthrough. Not to mention the whole part where it violates the laws of thermodynamics.

Can anyone link to a study (not an article) showing HFCS causing more weight gain in a calorie-controlled study that accounts for water weight and (preferably) doesn't have the people count their own calories?

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#16
post #6

Earlier quoted context omitted.

Yours has to be the most dickish comment on a comment I've ever read on HN. Congratulations. What is it that you've added to the conversation again ? Nothing.

As far as I can tell, everything he says is grounded in fact or is at least cogently supported. I intend to follow some of his pointers and read more. On the other hand, your comment is strangely and unintentionally self referential.

The problem was that the comment starts out with that comment about being a paid shill, and then goes on to treat the comment it replies to as if it was a series of firm claims made to mislead, when it starts out with a bunch of questions, and draws some very limited conclusions on the belief that we know too little.

MostAwesomeDude could have started out answering the questions on the assumption they are honestly meant, without the attitude, and it would have come across a lot better.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#17

"The rats in the Princeton study became obese by drinking high-fructose corn syrup, but not by drinking sucrose. The critical differences in appetite, metabolism and gene expression that underlie this phenomenon are yet to be discovered" The whole thing is one big correlation confirmation. I was hoping to find something substantial that would explain the underlying cause.

I'm no expert on this, but it seems like they were studying the problem in the wrong way.

Instead of considering HFCS as a food, and measuring how it works on your body, why not consider HFCS as a drug, and measure how it works on your brain? I think the HFCS->obesity issue has a lot more to do with the way sugar affects our brains.

I think HFCS is detrimental to human survival because it has encouraged us to get all of our happiness from food, leading to overeating and eating to "feel better" (it never happens) in some portions of the population. Thus, we are at this obesity issue, which is really a happiness issue. From my own personal experience: When you believe in yourself and you want to change, obesity becomes less and less of a problem because you are motivated to work out, eat better and generally take care of yourself. But the fact remains that you once ingested a drug to feel happy which also made you fat. Now you are eating food the way you're supposed to and not really getting that happiness that was once supplied by the sugary foods you were eating. You must use other drugs, like meditation or even alcohol/marijuana, to supplant this "completeness" feeling that you are missing from the lack of sugary foods.

Eventually, your body will give up the tolerance to sugary foods and you'll find yourself drinking sodas and eating dessert much less than you used to. Now, the general level of HFCS in all of our foods is no longer affecting your body weight and the way you feel about yourself.

I don't want to sound like a commercial here, but in the last 2-3 years I've been very much aware of my sugar-rich diet and began to slowly wean myself off of the addiction, and I can happily say that I've gone from a size 40 to a size 36 waist and lost over 20 pounds in the last year alone by simply being aware of how sugar affects your mind AND body, getting more exercise, and eating smaller portions of healthier food.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#18
post #3

Stop giving out corn welfare to corporations and problem solved. It's the ONLY reason why it's so heavily used. Corn syrup and ethanol - two massively damaging products of a completely corrupt system that everyone refuses to change because of massive profits off taxpayers.

Thanks for the laugh. You know you've reached the pinnacle of "first world problems" when a phrase like corrupt system, which has historically been used to describe things like institutional discrimination and genocide, is now used to describe the "horrors" of agricultural subsidies and tariffs. I'm surprised that Amnesty International hasn't updated their corruption index accordingly, which would surely put every sovereign nation's score in the single digits.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#19
post #2

I don't understand the mechanism here. I thought sucrase, the enzyme that breaks down sucrose (table sugar) into 1 fructose and 1 glucose (same as HFCS), acted almost immediately -- at least on the timescale of nutrient absorption. Is it just short circuiting our sense of satiety? Maybe the raw fructose makes things sweeter and stimulates reward centers better? I wonder where honey falls in all this since it has high…

You sound like you are a paid shill. I know that you aren't, which disappoints me further, because I'd like to think that people are capable of educating themselves instead of spreading misinformation. On your first paragraph, pondering whether sucrose breaks down into fructose and glucose immediately: No, it doesn't. HFCS makes sugars available to the bloodstream sooner, causing larger swings in overall blood sugar…

Why exactly do you believe it is warranted to reply in this tone? To me, regardless of the issue being discussed, this comment reflects extremely poorly on you.

Re: High-fructose corn syrup prompts considerably more weight gain than sugar (2010)

#20
post #2

I don't understand the mechanism here. I thought sucrase, the enzyme that breaks down sucrose (table sugar) into 1 fructose and 1 glucose (same as HFCS), acted almost immediately -- at least on the timescale of nutrient absorption. Is it just short circuiting our sense of satiety? Maybe the raw fructose makes things sweeter and stimulates reward centers better? I wonder where honey falls in all this since it has high…

You sound like you are a paid shill. I know that you aren't, which disappoints me further, because I'd like to think that people are capable of educating themselves instead of spreading misinformation. On your first paragraph, pondering whether sucrose breaks down into fructose and glucose immediately: No, it doesn't. HFCS makes sugars available to the bloodstream sooner, causing larger swings in overall blood sugar…

First of all, I tend to agree with the sibling posts accusing you of failing to maintain scholarly decorum. The "paid shill" remark was uncalled for, even if I tend to agree with your criticisms (at least, all but the most crucial one).

> pondering whether sucrose breaks down into fructose and glucose immediately: No, it doesn't.

Can you substantiate this further (say, with an in-vivo sucrose half-life)? I don't have journal access at the moment, so the best I could find was this study: http://ajplegacy.physiology.org/content/59/1/413.extract which seems to support what you claim (only 90% inversion after 6.5 hours in rabbits), but I'd still like to see something more modern and preferably in humans.

> Additionally, this study covers rats which were given strict diets

Strict diets? It seems to me like they had unmeasured and uncontrolled access to chow and sugar solution ("controlled" only on the basis of availability time)! I tend to agree with the grandparent post that the observed results could be caused by the relative sweetness of HFCS driving the rats to continue consuming HFCS past the point where they would have stopped consuming sucrose solution. Since humans tend to consume drinks in fixed quantities (8oz, 16oz) not entirely chosen on the bases of satiety, I question the relevance of this study to human health.

> you contradict yourself by noting (correctly) that HFCS is not half-and-half fructose and glucose

You quibble. I'll take it back iff you substantiate the implicit claim (which occurs under the assumption that you weren't quibbling) that the 5% or 7% difference in sugar concentrations creates a disproportionate effect on energy output or weight gain.

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