When working in Clojure, you tend to experiment a lot with the REPL. And the environment (Emacs, clojure-mode, nRepl and Lein) feels like having a dynamic IDE ... so you write code in your text file and with a single short-cut, you recompile your code and then move over to the nRepl window that you keep open in Emacs and you invoke whatever you wrote, to see if it works.
So it's like working with Ruby's irb, or with iPython, except that the integration with Emacs is so freaking nice. So the whole workflow ends up being a back and forth between the code buffer and the repl buffer. And it happens really fast too.
Clojure does have a slow startup, thanks to the JVM. It's not so bad on capable computers though. But that's not the point. The point is that having to restart a repl session interrupts your flow.
Note: I only played with Clojure, haven't done anything serious in it. My favourite is Scala and it would be nice if the Scala repl would do a fast reload on file changes. I don't need it in Scala though, as in Scala you tend to rely less on the repl.