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Are you going to change the world? (Really?)

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Re: Are you going to change the world? (Really?)

#11
post #8
post #6

Earlier quoted context omitted.

I'm interested. I've already tried to invest in lower-cost diagnostic kits for other diseases, but the company never achieved their price goals. I am, I might add, probably the last person on earth that should be investing in life sciences since all my experience is in business/financial services, marketing and software. I have a decent amount of experience with patents, though. Quick question: What is the real benef…

For people that are HIV+, the CCR5 delta32 mutation indicates a slower progression to AIDS. It's not a reliable enough measure to adjust dosages of anti-retroviral drugs though eventually we expect CCR5 delta32 to be part of a suite of tests to determine optimal HIV drug dosage. For HIV- individuals, the test can provide relative peace of mind. We still strongly advocate safe sex to everyone but certain populations o…

Yeah, I read your site. I'll email you, but I'm posting this here to get input on this issue from others. Cheap marketing research. I really don't mean to bust chops.

I'm just not sure I agree with the 'feel good' angle of your diagnostic kit. There seems to be three options you can take with a genetic testing kit:

1."You are naturally resistant to X. Yay for you."

2."You are going to get or already have X disease. Sucks to be you. Please take your diseased carcass elsewhere to cry."

3. "You have an increased risk for X. Here are some things you can do about it."

I can see wanting to avoid option two, but I like option three better than option one. I guess I'm a pessimist. I'd much rather learn that I have an increased risk than a reduced risk (Well, I don't really want ANY bad news...but you know what I mean.) Knowing my wife was genetically predisposed to skin cancer, for example, would have allowed us to be more proactive in monitoring her skin and making appropriate decisions regarding food, stress, sunlight, etc. Instead, we were just lucky. Now we know, and we were also able to have the rest of her family get checked out. There is a known gene mutation for skin cancer and it would have been nice to know about it.

Re: Are you going to change the world? (Really?)

#12
It has to be mentioned:

http://www.paulgraham.com/procrastination.html

http://www.paulgraham.com/hamming.html

But you know, I just want to pipe up in defense of us pipsqueaks. I run a website that helps people find a home to buy that is at most, if it works great for them, maybe 5% or 10% better or cheaper (your pick) than what they could have gotten otherwise. And even then, only in the LA area. Is that really about the best thing I (along with my co-founder) could've been working on the last two years?

I'm going to say yes, and here's why. Three reasons. One, opportunity. I work with semi-realistic options -- it's not productive of me, a 90's college dropout, to pursue medical research at this point. But I have ten years of experience programming and I do at some point need to put food on my family, as the saying goes.

Two, passion, or you could say just motivation. This is a problem that I have faced, my parents faced, their parents faced. I know the technology can make it better and am fascinated with the possibilities. I believe passion is immensely important to making the most of one's talent.

Three, getting the ball rolling. As an innovator in a little bitty part of the gigantic web, one who can only implement a tiny fraction of the things I want to, I know I have a limited impact. But twenty years from now, for all I know, people around the world could be using stuff like what I'm pushing into the market. I have no idea what impact that will have.

So hey, if I make money, I would appreciate that, but I really think I'm doing what I want to do with what I've got regardless of that. But if you have the interest, let me hear more about your pitch for what I or someone like myself could be doing instead, because this is, after all, a subject of vital interest.

Re: Are you going to change the world? (Really?)

#13
Is making an AJAXified tool or toy that will likely be used by less than 1% of the people in the richest country in the world the absolute best use of your time and talents right now? Honestly?

This is a good question. Here are some thoughts about the answer in a general sense:

Why do people make ajax websites like that? To get money, mostly. (It's also fun because programming is fun.) How do you get rich making a website? You make something that people want. This is capitalism at its finest. It's selfless. It's practically altruistic. You don't think about your idea of what makes the world a good place, you just make what other people want, and you trade it to them at a price they are happy with (which can be as cheap as just some ads on the side). Another way to put it is that you are cooperating with most of society. This is much better than nothing, it's a good thing. There might be something better, but we can think of it as starting point.

It's better than that, actually. There is an idea that the richest country doesn't need more help, doesn't need further luxury. This is a misconception. We are the richest country because we have the most productive people. If you give the most productive people more of what they want, you get the best return on investment in terms of worldwide increase in productivity. More precisely, if someone creates a million dollars of wealth per year, then if you can make him happier, make his life more convenient, etc, and increase his productivity by 1%, that's 10k per year. If you help someone who only makes a thousand dollars of stuff per year, if you can double his productivity that's only 1k per year. So targeting a rich country for who to help is not fundamentally a bad thing. And the richer we are, the easier and less costly it is for us to help others, and also the better science, medicine, etc we have to help with, so it really does improve the whole world to improve the USA.

So, making what other people want (even if they are rich), like fancy web 2.0 websites, is a perfectly reasonable thing to do. But is it ideal? Not necessarily. Sure "most people" in aggregate are productive, and make the world better over time. But if you are exceptional, you can have a larger effect by working on your own idea about how the world should be. This is harder because if you don't flow with the mainstream you have less people to cooperate with. And it's riskier because new ideas are often mistakes. So I wouldn't push people towards attitudes like this. Most people are too arrogant already and think they understand more than they do.

And also if someone doesn't realize they should be doing something better, it's very possible it's because they aren't that exceptional after all. Perhaps much better than average, but not inspired and brilliant -- and courageous and bold -- enough to see important problems they should be facing and to face them.

You mention medicine. It's quite possible more people should be working on medicine; I think that is the case. But I wouldn't guess programming is where they should come from! I'm sure there are individuals who would be well suited to switch. But there are plenty of bad fields that cater to bad things people want, but shouldn't want; let's loot those for talent ;p. Programming is a field that's very important and really could use some better people.

Even for narrowly focussed programmers there are big important problems one can work on. In a lot of ways the field is a total mess. The popular languages have huge flaws (including even Ruby and common lisp, not that they are very popular). Maybe Arc will solve this, we'll see. Ajax and current browsers could be vastly improved (no, I don't know the answer). And if they were, all the average programmers would be saved a ton of pain b/c they'd work on a better designed platform. Or saving all the java programmers by giving them better ways to solve their 'enterprise' problems -- and making it straightforward enough they can do it -- would have a huge impact. The man hours wasted because no super smart person has gone and fixed these things yet is ... hard to estimate ... 500k programmers * 400 hrs a year? Probably more than that :( It is very, very hard to fix these things. There is a lot of momentum behind the way things are done now. And a lot of thought and evolution went into them. I don't mean to put down all the people who haven't vastly improved the status quo. I'm just saying there are ways one can make a very large impact without doing medicine. And there are lots of more medium sized, approachable programming problems to be solved that would have a much larger impact than a new calendar with slightly better ajax, so maybe we should encourage people to look for those.

Hope that was interesting and helpful.

PS I have an idea for saving the world (nothing to do with the above, or with medicine, actually) that you might be interested in, but I don't want to post about it in public. My email is curi@curi.us Email me or post your email and I'll tell you.

Re: Are you going to change the world? (Really?)

#14
post #11
post #8

Earlier quoted context omitted.

For people that are HIV+, the CCR5 delta32 mutation indicates a slower progression to AIDS. It's not a reliable enough measure to adjust dosages of anti-retroviral drugs though eventually we expect CCR5 delta32 to be part of a suite of tests to determine optimal HIV drug dosage. For HIV- individuals, the test can provide relative peace of mind. We still strongly advocate safe sex to everyone but certain populations o…

Yeah, I read your site. I'll email you, but I'm posting this here to get input on this issue from others. Cheap marketing research. I really don't mean to bust chops. I'm just not sure I agree with the 'feel good' angle of your diagnostic kit. There seems to be three options you can take with a genetic testing kit: 1."You are naturally resistant to X. Yay for you." 2."You are going to get or already have X disease. S…

Hoo boy, I can hear it now. "Hey, according to this genetic test, it looks like your body naturally produces lots of LDLs, now let me tell you about Vytorin!"

Re: Are you going to change the world? (Really?)

#15
post #12

It has to be mentioned: http://www.paulgraham.com/procrastination.html http://www.paulgraham.com/hamming.html But you know, I just want to pipe up in defense of us pipsqueaks. I run a website that helps people find a home to buy that is at most, if it works great for them, maybe 5% or 10% better or cheaper (your pick) than what they could have gotten otherwise. And even then, only in the LA area. Is that really about…

Good for you, dude. That's awesome! It sounds like you ARE making a difference with your site. And there really is no need to feel defensive. Like I said, I was just trying to start a discussion...and maybe prompt a goal or gut check.

I'm not necessarily trying to push anyone to do something different or 'better' with their life. I mean...who the hell do I think I am? [Nobody.] I just asked the question because I think everyone sometimes forgets to evaluate their place in the world and what they can accomplish when they are really focused on one thing. It's like speeding on the highway and missing the scenery. And I also don't like to see wasted potential, especially when it is just because someone never really thought about what they were doing and why. And I was also just curious.

I'd read the procrastination article, but not the Hamming one. Thanks for the pointer.

Re: Are you going to change the world? (Really?)

#16
post #14
post #11

Earlier quoted context omitted.

Yeah, I read your site. I'll email you, but I'm posting this here to get input on this issue from others. Cheap marketing research. I really don't mean to bust chops. I'm just not sure I agree with the 'feel good' angle of your diagnostic kit. There seems to be three options you can take with a genetic testing kit: 1."You are naturally resistant to X. Yay for you." 2."You are going to get or already have X disease. S…

Hoo boy, I can hear it now. "Hey, according to this genetic test, it looks like your body naturally produces lots of LDLs, now let me tell you about Vytorin!"

OR: "Lay off the bratwursts, Lardass!"

Maybe they just need a "Don't be evil" motto? [chuckles]

Wow. It's after 4am here. Goodnight.

Re: Are you going to change the world? (Really?)

#17
post #13

Is making an AJAXified tool or toy that will likely be used by less than 1% of the people in the richest country in the world the absolute best use of your time and talents right now? Honestly? This is a good question. Here are some thoughts about the answer in a general sense: Why do people make ajax websites like that? To get money, mostly. (It's also fun because programming is fun.) How do you get rich making a we…

Good points. I agree with you.

[One of the reasons I put so many disclaimers in my post is that I was worried I would come off as a self-righteous prick who was saying what people are doing now is not good enough and everyone should go into medicine. Which is totally not the case.] You also make me feel better, because you made a looong post too. I don't feel as windy now.

Non-medicine ideas sound even better to me actually, because then I can maybe understand them ('circle of competence' and all that.) The guy that started the self-sustaining business selling mosquito nets made by local workers for malaria prevention had the type of idea I'm interested in.

Is my email address not showing up in my profile? It's dcphillips /AT/ runbox /DOT/ com.

Re: Are you going to change the world? (Really?)

#18
post #10

I don't know... there are tons of people in medical research that perhaps "do their bit", but don't do anything really important. I think that as long as you are doing what you do well honestly and with integrity, and it's basically something that creates value... do that, and don't worry if there's something else that could be improving the world more - perhaps you wouldn't do as good a job as you do with what you t…

Opportunity costs!

Re: Are you going to change the world? (Really?)

#19
If the reason behind being an entrepreneur is make a difference then you might as well quit now. Making a difference is a byproduct of capitalism. If you really want to "make a difference" make your money the do as bill gates and warren buffet did, I'm also sick of VCs saying that they are looking for companies that want to make a difference. what a sack of shit, I'm in it for the same reason they are, and thats to make a bundle of money.
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