Earlier quoted context omitted.
Prezi gives me motion sickness. I don't see the point.
Using it right is a little bit of a skill. Too much panning and zooming can be bad, but just the right amount makes the presentation seem more fresh and alive than a ppt. I've been using prezi for a few years now, and almost always get good audience feedback. Like any tool, you still have to know how to use it, it will not do all the work for you.
The best slide presentation software I've seen so far is SlideShow, but its for programmers only :)