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Show HN: My friend's project to simulate an entire C. Elegans

nemaload.davidad.org

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Re: Show HN: My friend's project to simulate an entire C. Elegans

#3

Interesting .. although a similar project already exists ( http://www.openworm.org/ ), and is, from a cursory glance, much more developed.

Doesn't seem to be same thing. OpenWorm is computer simulation, while the OP plans to build a model based on observing an actual living individual [1].

[1] http://nemaload.davidad.org/about

Re: Show HN: My friend's project to simulate an entire C. Elegans

#6
post #4

Oooh Exciting stuff! I've been following openworm off and on for a while now. The projects should be extremely complementary. I hope they communicate. (This projects is going to collect a totally new dataset)

Yes, I know Stephen Larson and some of the other OpenWorm guys. In fact, I'm even a member of their organization on GitHub " rel="nofollow">https://github.com/openworm?tab=members>. Once both projects are a bit more developed, I expect ample opportunities for substantive cooperation; but for now, I'm focusing on data collection challenges, while they're focusing on simulations, visualizations, and data management.

Re: Show HN: My friend's project to simulate an entire C. Elegans

#8

This has been out for a while. Would be interesting to see the next steps.

Yeah, I haven't updated the site in a while. (This really wasn't the best time for a Hacker News blitz. I was just telling my friend that Nemaload hadn't been on HN yet, as far as I knew, and he simply decided to fix that pronto.) But there have been plenty of developments since November (when I think I last updated the site). I have access to a few candidate strains for pan-neuronal calcium imaging (though the genetic engineering is still an ongoing optimization process) and have collected a couple of large datasets, one on a light-sheet microscope and one on a light-field microscope. Much of the data is useless, and we're still working on the algorithms to extract signals from it, as well as the infrastructure for opening it up for distribution. But there will certainly be more publicly visible activity soon (June at the latest).

Re: Show HN: My friend's project to simulate an entire C. Elegans

#9

Interesting .. although a similar project already exists ( http://www.openworm.org/ ), and is, from a cursory glance, much more developed.

Doesn't seem to be same thing. OpenWorm is computer simulation, while the OP plans to build a model based on observing an actual living individual [1]. [1] http://nemaload.davidad.org/about

That's about right. My end product is also a computer simulation, as far as that goes, but I'm taking an obsessively data-driven approach, motivated by the advent of new technologies for single-neuron measurement and perturbation in living, behaving animals. Meanwhile, OpenWorm is taking a bottom-up approach, driven by physics and other first principles. We'll meet in the middle eventually.
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