Did you look at Julia[0]?
It is a Lisp, semantically, with a MATLAB-like syntax (including all the linear algebra sugar), and a LLVM back end.
The stated goal of the language is to give to scienctific programmers the convenience of high level languages for prototyping, yet the speed of low level ones. It has multiple dispatch, based on a powerful type system, homoiconicity and macros (optionally hygienic).
The package collection is growing steadily [1]. There's also a mailing list dedicated to doing statistics with Julia[2].
I looks like a good fit for your project.
[0] http://julialang.org
[1] http://docs.julialang.org/en/release-0.1/packages/packagelis...
[2] https://groups.google.com/forum/?fromgroups=#!forum/julia-st...