One Drug to Shrink All Tumors
news.sciencemag.org
One Drug to Shrink All Tumors
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Re: One Drug to Shrink All Tumors
#2"Although macrophages also attacked blood cells expressing CD47 when mice were given the antibody, the researchers found that the decrease in blood cells was short-lived; the animals turned up production of new blood cells to replace those they lost from the treatment"
That's great -- does anyone know if any other cells in the body express CD47? Especially ones that can't be replaced so easily?
Re: One Drug to Shrink All Tumors
#3Some heart-wrenching comments from the page:
"Husband and father of 3, age 31, high grade spindle cell sarcoma, stage 4 with mets- help! nuclearcouple@hotmail.com or find me (spouse) on fb, Heather Cimino in Fort Myers, Fl, willing to travel anywhere, just save my husband!"
"my wife has tumor that are killing her will you hurry up and get this sorted - is there anyway one can volunteer for a trial tim.parry@xtra.co.nz"
There has got to be a way to address this need.
Re: One Drug to Shrink All Tumors
#4Some heart-wrenching comments from the page: "Husband and father of 3, age 31, high grade spindle cell sarcoma, stage 4 with mets- help! nuclearcouple@hotmail.com or find me (spouse) on fb, Heather Cimino in Fort Myers, Fl, willing to travel anywhere, just save my husband!" "my wife has tumor that are killing her will you hurry up and get this sorted - is there anyway one can volunteer for a trial tim.parry@xtra.co.n…
There is, "expanded access" or "compassionate use". http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocat...
Re: One Drug to Shrink All Tumors
#5Some heart-wrenching comments from the page: "Husband and father of 3, age 31, high grade spindle cell sarcoma, stage 4 with mets- help! nuclearcouple@hotmail.com or find me (spouse) on fb, Heather Cimino in Fort Myers, Fl, willing to travel anywhere, just save my husband!" "my wife has tumor that are killing her will you hurry up and get this sorted - is there anyway one can volunteer for a trial tim.parry@xtra.co.n…
There is, "expanded access" or "compassionate use". http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocat...
How many months or years does that process take?
Morally speaking, the judgement of a patient (and the physician he has chosen) must not be impeded even for an instant. The FDA renders individual judgement on these matters irrelevant, and the result is often death and slowed medical progress.
Re: One Drug to Shrink All Tumors
#6"Although macrophages also attacked blood cells expressing CD47 when mice were given the antibody, the researchers found that the decrease in blood cells was short-lived; the animals turned up production of new blood cells to replace those they lost from the treatment" That's great -- does anyone know if any other cells in the body express CD47? Especially ones that can't be replaced so easily?
No specific answer from me, but I guess digging through some top entries from pubmed can answer that. http://www.ncbi.nlm.nih.gov/gene?term=%28cd47[gene]%29%20AND... may be a good start.
Re: One Drug to Shrink All Tumors
#7Earlier quoted context omitted.
There is, "expanded access" or "compassionate use". http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocat...
How many months or years does that process take? Morally speaking, the judgement of a patient (and the physician he has chosen) must not be impeded even for an instant. The FDA renders individual judgement on these matters irrelevant, and the result is often death and slowed medical progress.
I imagine these people are desperate enough to find other means to acquire an antibody that blocks CD47. I wonder what quasi- or il- legal means are available to them? Care to speculate?
Edit: perhaps a set of crowd-sourced, extremely explicit instructions about how to manufacture, purify, and test such antibodies would be a start. With such a set of instructions, they might be able to find experts to help them under the table.
Re: One Drug to Shrink All Tumors
#8Some heart-wrenching comments from the page: "Husband and father of 3, age 31, high grade spindle cell sarcoma, stage 4 with mets- help! nuclearcouple@hotmail.com or find me (spouse) on fb, Heather Cimino in Fort Myers, Fl, willing to travel anywhere, just save my husband!" "my wife has tumor that are killing her will you hurry up and get this sorted - is there anyway one can volunteer for a trial tim.parry@xtra.co.n…
There has got to be a way to address this need.
Yes, there is. Fight for the right of each individual to follow his best judgement in regard to all matters pertaining to his own life. (If someone doesn't know enough to make the call, he knows enough to choose a physician who can.)
Right now, timely experimental treatments are basically outlawed. What good is it to say that there's an FDA procedure to get around the controls if you're treated too late? What right does anyone have to deprive anyone else of what might be their only shot at life?
Re: One Drug to Shrink All Tumors
#9Some heart-wrenching comments from the page: "Husband and father of 3, age 31, high grade spindle cell sarcoma, stage 4 with mets- help! nuclearcouple@hotmail.com or find me (spouse) on fb, Heather Cimino in Fort Myers, Fl, willing to travel anywhere, just save my husband!" "my wife has tumor that are killing her will you hurry up and get this sorted - is there anyway one can volunteer for a trial tim.parry@xtra.co.n…
There has got to be a way to address this need. Yes, there is. Fight for the right of each individual to follow his best judgement in regard to all matters pertaining to his own life. (If someone doesn't know enough to make the call, he knows enough to choose a physician who can.) Right now, timely experimental treatments are basically outlawed. What good is it to say that there's an FDA procedure to get around the c…
Didn't know it was this bad, but couldn't agree more. It should be entirely up to an individual what they put in their body. Monumentally frustrated right now.
Re: One Drug to Shrink All Tumors
#10My best friend was just put into hospice for metastasized melanoma. He's 35. Where is this stuff?
Nothing more useful to add to this comment. Sorry