Earlier quoted context omitted.
What does that mod do out of curiosity?
"mpm-itk allows you to run each of your vhost under a separate uid and gid—in short, the scripts and configuration files for one vhost no longer have to be readable for all the other vhosts" - http://mpm-itk.sesse.net/
I mean, I understand why Apache needs to do it: with Apache, you have things like mod_php running in-process, so it makes sense to restrict Apache, running one of Bob's scripts, from accessing Alice's files.
But with Nginx, anything with "intelligence" runs out-of-process. What Nginx expects you to do is to run it as one user, but run each app server (in PHP terms, each FCGI socket daemon) as the user whose files that server should access. (Or, better yet, run the app server in an LXC container along with a bind mount to only the files it needs to access. Very Plan9y.)