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It’s a part of my paleo fantasy, it’s a part of my paleo dream

sciencebasedmedicine.org

131–140 of 205 posts

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#131
post #33

Earlier quoted context omitted.

There was an interesting study done - and written up on SBM - that suggests that the theraputic effect of Alt-med, at least with acupuncture, is entirely due to patient-practitioner interaction. As someone on the cusp of becoming a Doctor, I understand this. I even understand why traditional medicine fails at it (and it is many of the reasons you mention). And I understand why Alt-med succeeds here. I think it's grea…

What percentage of Conventional medicine practices are evidence based?, ie what percentage of what you as a conventional MD practice has been subjected to RCT? I have a friend who is a Internal Medicine MD who claimed it was less than 50%. If thats the case then every conventional MD continues "to pretend and/or believe that what they are doing has a real scientific basis". Please give me a % of what you do in a clin…

Well let's start with your last question first.

I'm not an American and I won't practice there. I'm Australian and we score an improved 19th on that league table. However I recently had the opportunity to study/work in a hospital in the states and these are some of my observations.

- The US healthcare system is fucked.

- there is a major disparity of care by region and neighbourhood (from my experience)

- poor people are discriminated against by the healthcare system

- these inequalities of care and resources are perpetuated down the line by a social system which doesn't support the most needy n society

In comparison, Cuba has one of the highest rates of doctors per capita and a healthcare system that performs astoundingly well, especially when compared on a dollar basis. You don't need high tech to perform life saving basic medical treatment, such as that which infant mortality measures.

I feel that the US healthcare system over-emphasises technology to deliver solutions, when what is actually needed are people on the ground in places where they are needed. Unfortunately for those people, they are unable to pay so no-one is going to go to them.

Now to the meat and potatoes of your claim. Firstly let me say that it strikes me as a bit aggressive. I said * in the same way as taking a drug that has been through a RCT does.*

If I am to respond to your whole query, then really I am throwing open the whole of medicine. And it's a big area. Everything from the correct techniques for birthing to height projection charts for children, through immunisations and treatment for common illnesses, to whole specialties of cardiology, renal medicine, .... Many many more.

But let me give you some anecdotes to show you how much of medicine HAS been studied. Maybe You will cry 'liar, deceiver!'. Or maybe I will be able to convey to you a bit of the never-ending torrent of information every doctor is swimming in (and I will admit, there are some that simply stop looking at it all).

Firstly. We have to do assignments called PEARLS. basically, w come across a clinical question and go and try and find evidence for it. As (at the time) a 3rd year med student, I still didn't really have much idea what was going on in the hospital, let alone how to formulate a clinical question and find an answer.

My question involved an elderly patient who had been transferred to the service I was on. He was on an ace inhibitor and an Angiotensin-receptor blocker. That is, 2 types of drugs which supposedly do the same thing.

This was a bit weird to me but it turned out there is some plausible science behind it - combination treatment might lead to being able to use lower doses, which can mean less side effects, as well as more effective RAAS blockade which might lead to better control of blood pressure.

Well it turned out that for this question I thought was stupid and pointless there had been a recently completed RCT, The ONTARGET Study, which proved that dual blockade is worse than single drug use.

My housemate is currently doing his, and his clinical question is whether an infected abdominal surgical wound should be closed or left open. Also seems like a Bizzare question but turns out there are several papers on this, and they say that the wound must be left open.

No RCT this time, but it is notoriously hard to do RCTs in surgical patients for reasons I'm sure you can understand.

A thir anecdote: when we start med, they tell us that 50% of what we learn will be obsolete at the end of 4 years of study, the problem is we don't know which 50%. Such is the rate of scientific advancement.

When I first heard this I just thought it was an embellishment, a story designed to boast of the speed of discovery. Turns out its true. Some significant changes have occurred since I've started studying that have overturned long-held practices.

An example would be the use of lidocaine and adrenaline/epinephrine in local anaesthetic for closing a wound in the extremity.

It was thought that the adrenaline would cause vasoconstriction which would lead to infarction and possible loss of a finger or toe if used. Recently a RCT was performed which showed it to be totally safe. That Overturned a practice that had been going for many many years.

The truth is, I can't give you a figure for the amount of evidence that has an RCT done for it. This is not shirking from the responsibility, but it is simply admitting that the scope of the practice of medicine is so unimaginably vast that even after spending 4 years deep in the thick of it, I know I will only ever be able to be proficient in a tiny area of the whole.

I can assure you, however, that people are working hard to ensure that everything will be studied. I would estimate that 99%+ of our practice has been published in some form, ranging from the worst - simple case reports, through to the most expensive and rarest- RCTs. We even study how reliable the examination signs are - by this I mean the percussion of fingers on your chest to detect various conditions (dullness indicating pneumonia has a likelihood ratio of 3, hyper resonance indicating COPD has a positive LR of 5.1) and every other thing that we do.

Some of these studies are bad; some are outdated; and sometimes we do things for years because they became habitual and weren't re-examined for a long time. And sometimes these things cause harm to patients.

But you can bet that it is the aim of medicine, and of science, to test and re-test all of the things we do, continually, with the aim of improving our practice and providing better and safer care.

The same can't be said of alternative medicine

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#132
I've been on the paleo diet for about a year.

Besides the fantastic results I've had with it, the main reason why I'm confident in it is the fact that what is known to be true in nutritional science changes all the time. Meanwhile, I'm very confident we know what our paleo ancestors ate for hundreds of thousands of years prior to the introduction of agriculture. Even if it is eventually proven that grains do not cause a problem with our diet, we should be confident that avoiding them should not be detrimental to our health given the fact that we didnt eat them for a huge span of human existence

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#133
post #119

Earlier quoted context omitted.

This is the part of your comment where I thought you were implying a more general irrationality of women: >It feels like a big gaping hole in everything we achieved with women's rights and education. [. . .] It's like a large part of our women went to a parallel universe "girls school", whereas the men in the mean time learned about science and reasoning. If you're not implying that a large portion of women are less…

If you read my other comments it should be abundantly clear what I mean. And I don't see how you somehow extract the exact opposite of it from my text. > It feels like a big gaping hole in everything we achieved with women's rights and education. I said that because it is. It feels like a giant setback. There is absolutely nothing in here to remotely suggest I could be thinking that women are less rational than men.…

I did not mean to accuse you of saying that women are predisposed for less rationality than men. Sorry for the confusion.

With that said, you still, to me, seem to be saying that women are currently employing less rationality than men, due to failure in education, culture, or something else. This is what I want to dispute. I disagree that alternative medicine being more popular with women means that women as a whole have been given less critical thinking skills. I think it's just because some things are more popular with women, and some with men. Alternative medicine appears to me to be something that is more popular with women, and it also happens to be irrational.

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#134
post #117
post #33

Earlier quoted context omitted.

There was an interesting study done - and written up on SBM - that suggests that the theraputic effect of Alt-med, at least with acupuncture, is entirely due to patient-practitioner interaction. As someone on the cusp of becoming a Doctor, I understand this. I even understand why traditional medicine fails at it (and it is many of the reasons you mention). And I understand why Alt-med succeeds here. I think it's grea…

You might find this quite interesting: http://programinplacebostudies.org/ http://harvardmagazine.com/2013/01/the-placebo-phenomenon His studies comparing fakes strike me as the most innovative thing I've heard about in medicine in years. A big problem with "conventional" medicine is this: the mind is off limits. This legacy I think goes back to the suppression of deep mind research following the psychedelics moral p…

Thanks for bringing this to my attention.

I agree that the mind's contribution has been shut out of things. I don't think it's right but I do think there has been sound reason not to: we just don't understand enough about how the interaction works.

We are entering into a really interesting new era as investigation into these areas begins again

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#135
post #100

Earlier quoted context omitted.

Following the reference through from the "clinical trials" section, the Wikipedia article is a little misleading. It makes it sound like only 356/1000 random plants have been studied, but in the paper [1] the breakdown is actually: 15.7% had been tested in clinical trials; 50.9% had been tested in vitro or in vivo; 20.8% had been subject to a phytochemical study; 12.1% had no studies found in the literature search; 0…

I was thinking we are talking about all plants in existence, this is a study of 1000 most commonly used herbs, still, I learned something new, so thanks. Still it doesn't prove your more bold claim that somehow all the potential benefits of using them are already available in a very safe to use pill.

My overconfidence is mostly coming from the long tail.

Even if there are millions of distinct plant chemistries out there, a small number (say, 100) will account for 90% of the herbal remedies prescribed and taken. These will have been studied by scientific methods exhaustively. The next most common chunk will have received some cursory attention, and then you enter into the vast fields of the unknown.

But the fields aren't unknown to just science: they're unknown to cultural practitioners as well. I'm willing to believe that, even without double-blind clinical trials, people were able to find effective treatments with enough trial and error. But "enough trial and error" means "not the long tail". So once you start talking the 1000th most common plant used for medicinal properties, the amount of experience pre-scientific practitioners have accumulated is negligible, and handful of anecdotes at best. Not even enough to ascribe correlation, let alone causation.

So on the head of plants of potential value, I'm betting that they've all been studied exhaustively. On the tail, there are countless plants which could have countless benefits, but essentially no evidence to do anything but pick one at random and hope it cures what ails you. The middle, of enough evidence to suspect or know a plant does something, but not how, is going to be fairly small.

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#136
post #119

Earlier quoted context omitted.

If you read my other comments it should be abundantly clear what I mean. And I don't see how you somehow extract the exact opposite of it from my text. > It feels like a big gaping hole in everything we achieved with women's rights and education. I said that because it is. It feels like a giant setback. There is absolutely nothing in here to remotely suggest I could be thinking that women are less rational than men.…

I did not mean to accuse you of saying that women are predisposed for less rationality than men. Sorry for the confusion. With that said, you still , to me, seem to be saying that women are currently employing less rationality than men, due to failure in education, culture, or something else. This is what I want to dispute. I disagree that alternative medicine being more popular with women means that women as a whole…

> I disagree that alternative medicine being more popular with women means that women as a whole have been given less critical thinking skills

Well, we're failing women here somewhere and my first guess would indeed be the education system in general, and maybe the image of science education in particular. I'm not saying that women generally employ less critical thinking skills (hence my original comment about astrophysics in that context), but at the same time there is very clearly something wrong that makes women more susceptible to this C/AM bullshit. There are clearly antibodies missing here, the question then becomes why are we giving those antibodies to men and denying them to women?

> I think it's just because some things are more popular with women, and some with men.

Sure, though as I said in other comments, by default I tend to attribute these things overwhelmingly to culture, not physiology. Being susceptible to C/AM and other crap is not a cute little boy-girl difference, however. It's a massive problem, because having a mind with this faith-based nonsense in it is clearly a disadvantage that precludes victims from actually understanding the world. Not to mention it's a risk whenever "alternative medicine" is favored over actual treatment in critical situations.

> Alternative medicine appears to me to be something that is more popular with women, and it also happens to be irrational.

My point is, that needs to change. It's not an innocent phenomenon. There is something deeply wrong here. To shift the focus a little, do you know which group is also extremely susceptible to non-scientific bullshit? Medical doctors. It's a huge problem. We're currently addressing this issue both in medical school and in hospital culture, but it's still an uphill battle. We need to do the same for women.

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#137
post #33
post #12

I have a friend who's into homeopathy and such, and I normally keep my mouth shut. But I have done some thinking about why. This friend is very smart, very intellectual, very curious, and not overly credulous. She's really a bit of a nerd. From my few conversations on the matter, the thing that's jumped out at me is this: She's drawn to alternative medicine because it's open source. Like many nerds, she hates closed…

There was an interesting study done - and written up on SBM - that suggests that the theraputic effect of Alt-med, at least with acupuncture, is entirely due to patient-practitioner interaction. As someone on the cusp of becoming a Doctor, I understand this. I even understand why traditional medicine fails at it (and it is many of the reasons you mention). And I understand why Alt-med succeeds here. I think it's grea…

What is for you 'medicine proper'?

Do you mean it has been tested and found to work, even if it has nothing to do with medicine (some herbal supplement or meditation) or just medical approved/ordered?

I don't buy into much of the alt-med areas (homeopathy, acunpunture, etc, just not my cup of tea) but I do research a lot about natural 'supplements' and many have been proven quite useful for human health. In what category would you put this?

The other part of the problem is the influence medical staff have. One example is the food advice we have been getting the last couple decades.

'No fats, a lot of cereal. That's the way to live.' which still today doctors here advise (my dad is pre-diabetic, his doctor recommended to change to wholegrain bread and stop eating animal fat, and take his medicine, can't forget that along with his statins for the cholesterol!) which we all know now that isn't the way to go, but many doctors are still making their informed decisions by things they learned 40 years ago in medical school.

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#138
post #83

Earlier quoted context omitted.

The problem with herbalism is that it's the first place science-based medicine went looking for drugs. For basically any herb and effect someone ascribes to it, there have already been twenty rigorous studies, and either no statistical effect was found or the responsible chemicals were extracted, purified, concentrated, and synthesized and are now marketed under two brand names and three generics. Going to herbs dire…

The idea that plants can always be reduced to merely one of their components is an oversimplification. Ask anyone who smokes marijuana why different 'strains' of the plant have different effects, or why Marinol (the pharmaceutical name for THC) is perhaps more dangerous and less helpful or pleasant than the complex cocktail of cannabanoids in their natural delivery[1]. It's also why I'll drink green tea over taking g…

I am surprised you think this is a point in your favor. Yes, the primary active ingredient in marijuana is not sufficient. But you just said different strains of marijuana have different effects.

Which strain is most effective for glaucoma? Which strain is most effective for pain management during chemotherapy? Which strain doesn't help with either of those things? The same questions can be asked for any plant.

Medicines extracted from plants may not have the exact same effect as those plants, but they are much more predictable. The dose, the benefit, and the side effects can be studied and known. (And there is no reason to think the effect will be worse or weaker: the extra cocktail of chemicals in the plant could either amplify or dampen the primary active ingredients.)

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#139
post #130
post #26

Earlier quoted context omitted.

"By contrast alt-med is open. Anyone can learn about it. Anyone can become a practitioner. Anyone can experiment. It's also unmitigated bullshit. It's tolerant of different views and opinions because none of them are based on evidence. Alt-med is actually more free-enterprise. There is more patient choice. It's less expensive. The 'choice' is an illusion. None of it works so sure, choose what you like. It's less expe…

I don't disagree much on fact, but the attitude on display here is not helpful. It turns people off. There was a time when people were willing to trust authority figures and accept the advice of credentialed experts without question. That time is over. If you talk this way to people, they tune you out. Part of the reason for this is the Internet itself, and the general displacing of one-to-many communications with ma…

I'm not really sure I make appeals to authority, and the fact that I rip into stuff is me treating people as equals, not as fragile china dolls that need to be cosseted and persuaded with allusions to reality to persuade them down from their weird views.

I'm also pretty sure you're right that it puts a lot of people off, and I'm not the right person to talk to them :)

Oh and I absolutely agree that the days of listening to experts and authority figures are over. I'm not one. You'll find me the last person to say that the medical establishment has everything right, or that we should always listen to doctors because they're just so clever. I just think that most of the thought behind alt-med in its various forms is nonsense too.

Re: It’s a part of my paleo fantasy, it’s a part of my paleo dream

#140
post #100

Earlier quoted context omitted.

I was thinking we are talking about all plants in existence, this is a study of 1000 most commonly used herbs, still, I learned something new, so thanks. Still it doesn't prove your more bold claim that somehow all the potential benefits of using them are already available in a very safe to use pill.

My overconfidence is mostly coming from the long tail. Even if there are millions of distinct plant chemistries out there, a small number (say, 100) will account for 90% of the herbal remedies prescribed and taken. These will have been studied by scientific methods exhaustively. The next most common chunk will have received some cursory attention, and then you enter into the vast fields of the unknown. But the fields…

I agree with your reasoning, but you assume that the outcome of the research on a given plant will very quickly lead to a total understanding of its ingredients and effects and that it will always be feasible to develop a technological process to deliver the same complex of ingredients in the form of a pill, neither of which has to be the case.
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