I take psychedelics on a regular basis. Usually a couple of times a month. Although I've done several hundred micrograms (there is really no way of knowing) of LSD at once, I also really enjoy experimenting with smaller doses and casually micro-dosing on work days.
I happen to be a software engineer and try to apply my knowledge of "machines" to the psychedelic experience. While I don't believe in anything supernatural, I do think that there might be a chance that psychedelics, especially LSD, help your consciousness tap into some deeper abstractions of the human mind, maybe even the universe.
Let me explain that insane claim as best I can:
There is a great book on psychology that was published recently called: Thinking Fast and Slow. In summary, it goes into great detail about two systems of the human mind. System 1, the immediate reaction system, and system 2 which is responsible for computing and solving problems.
When your brain is in system 2 mode (solve 17 x 54 in your head) your heart rate increases, your pupils dilate, and your brain starts consuming glucose. It's doing work. System 1 is the trained mind that recognizes facial gestures and stuff infinitely more complex than a simple math equation. It reacts to danger before you are consciously aware of danger.
I would speculate that LSD turns on System 2 where normally my System 1 brain would give me an immediate response. Your mind starts processing information differently. This cascades into an incredible effect on your emotional awareness, creativity, introspection, insights, and behaviors both physical and cognitive.
I wonder if these extreme doses of LSD eliminate your minds ability to process normal sensory input. What you're left with are low level systems. You're self-awareness is turned off, but you are left with cognitive factories still churning away.
Imagine something sad that happened to you once. Now imagine the visual component is gone, the memory of language gone. You're left with the actual chemical response of the memory. Now do the inverse for something positive. That's what ego-loss is like. You're swimming in a sea of emotions as your brain randomly wanders off into different states, sometimes many at once, sometimes you get stuck in one. Sometimes that state is incredible panic, sometimes you're crying-laughing for 10 minutes straight. This is a common experience I've had on measly 300-500ug doses.
As for the universe claim, as far fetched as it sounds, maybe some of these systems are abstractions of the universal systems. What we are perceiving in these insane states are also little clues into how the universe organizes itself and a peek at something pre-selfawareness.
That last paragraph is all bull-shit heresy but even with my lighter doses I've had remarkable insights. Things that have changed my life in incredible ways. It's like a Pi of molecules or some shit.
edit: grammar