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Oh, yeah, definitely, I wish everything was as easy as "pip install". On the other hand, I can sympathize with nothing working on macs. This is because the environment plain sucks. All the installed tools and libraries are old as hell and rarely get updated, and it's riddled with quirks and tools that are subtly different on osx. I hear it's gotten better with Mountain Lion. Thank god for homebrew.
Macports is my tool of choice, but yes it's the only way to get things done! Unfortunately, plenty of scientific libraries are too obscure to be ported, leaving it to us scientists... Interesting what you say about 10.8 - I might give it a shot then. I will be upgrading soon from snow leopard (2009 MBP) and I was going to wipe and go debian/XFCE, because of all the "new ideas" like "let's not have save as" etc, but i…
But I got stuck with it because I had to do ios dev at some point, so I learned to adapt ...
I hear arch and ubuntu both work great out of the box on macbooks.